Circadian rhythms affect bone reconstruction by regulating bone energy metabolism DOI Creative Commons

Beibei Luo,

Xin Zhou, Qingming Tang

et al.

Journal of Translational Medicine, Journal Year: 2021, Volume and Issue: 19(1)

Published: Sept. 27, 2021

Abstract Metabolism is one of the most complex cellular biochemical reactions, providing energy and substances for basic activities such as cell growth proliferation. Early studies have shown that glucose an important nutrient in osteoblasts. In addition, amino acid metabolism fat also play roles bone reconstruction. Mammalian circadian clocks regulate cycles various physiological functions. vertebrates, rhythms are mediated by a set central clock genes: muscle brain ARNT like-1 ( Bmal1), like-2 (Bmal2), rhythmic motion output cycle stagnates (Clock), cryptochrome 1 (Cry1), cryptochrome2 (Cry2), period (Per1), 2 (Per2), 3 (Per3) neuronal PAS domain protein Npas2) . Negative feedback loops, controlled at both transcriptional posttranslational levels, adjust these genes diurnal manner. According to results on transcriptomic several tissues, expressed tissue-specific manner affected rhythms. The rhythm regulates activities, including metabolism, feeding time, sleeping, endocrine immune It has been reported mammals closely related metabolism. this review, we discuss regulation rhythm/circadian gene osteoblasts/osteoclasts bone, relationship between rhythm, remodeling, We therapeutic potential regulating or changing development/bone regeneration.

Language: Английский

Mitochondrial dysfunction as a critical event in the pathophysiology of bipolar disorder DOI
Giselli Scaini, Taylor Andrews, Camila Nayane de Carvalho Lima

et al.

Mitochondrion, Journal Year: 2020, Volume and Issue: 57, P. 23 - 36

Published: Dec. 17, 2020

Language: Английский

Citations

54
Mitochondria DNA copy number, mitochondria DNA total somatic deletions, Complex I activity, synapse number, and synaptic mitochondria number are altered in schizophrenia and bipolar disorder DOI Creative Commons
Sujan C. Das, Brooke E. Hjelm, Brandi Rollins

et al.

Translational Psychiatry, Journal Year: 2022, Volume and Issue: 12(1)

Published: Aug. 30, 2022

Abstract Mitochondrial dysfunction is a neurobiological phenomenon implicated in the pathophysiology of schizophrenia and bipolar disorder that can synergistically affect synaptic neurotransmission. We hypothesized share molecular alterations at mitochondrial levels. Mitochondria DNA (mtDNA) copy number (CN), mtDNA common deletion (CD), total deletion, complex I activity, synapse number, mitochondria were studied postmortem human dorsolateral prefrontal cortex (DLPFC), superior temporal gyrus (STG), primary visual (V1), nucleus accumbens (NAc) controls (CON), subjects with (SZ), (BD). The results showed (i) CN significantly higher DLPFC both SZ BD, decreased STG unaltered V1 NAc BD; (ii) CD BD while STG, V1, (iii) burden (iv) Complex activity lower which driven by presence medications, no alteration NAc. In addition, protein concentration, ELISA, was across three cortical regions subjects; (v) synapses female compared to controls. Overall, these findings will pave way understand better for therapeutic interventions.

Language: Английский

Citations

30
Association of serum homocysteine levels with intestinal flora and cognitive function in schizophrenia DOI
Hehua Li,

Hanqiu Li,

Zhimin Zhu

et al.

Journal of Psychiatric Research, Journal Year: 2023, Volume and Issue: 159, P. 258 - 265

Published: Feb. 1, 2023

Language: Английский

Citations

18
Species-specific FMRP regulation of RACK1 is critical for prenatal cortical development DOI Creative Commons
Minjie Shen, Carissa L. Sirois, Yu Guo

et al.

Neuron, Journal Year: 2023, Volume and Issue: 111(24), P. 3988 - 4005.e11

Published: Oct. 10, 2023

Language: Английский

Citations

18
Redox and Immune Signaling in Schizophrenia: New Therapeutic Potential DOI Creative Commons
Daniella Dwir, Inès Khadimallah, Lijing Xin

et al.

The International Journal of Neuropsychopharmacology, Journal Year: 2023, Volume and Issue: 26(5), P. 309 - 321

Published: March 28, 2023

Redox biology and immune signaling play major roles in the body, including brain function. A rapidly growing literature also suggests that redox abnormalities are implicated neuropsychiatric conditions such as schizophrenia (SZ), bipolar disorder, autism, epilepsy. In this article we review literature, its implications for pathophysiology of SZ, potential development novel treatment interventions targeting signaling. complex not fully understood; addition, there discrepancies especially patient-oriented studies. Nevertheless, it is clear arise SZ from an interaction between genetic environmental factors during sensitive periods development, these disrupt local circuits long-range connectivity. Interventions correct may be effective normalizing function psychotic disorders, early phases illness.

Language: Английский

Citations

17
Schizophrenia Synaptic Pathology and Antipsychotic Treatment in the Framework of Oxidative and Mitochondrial Dysfunction: Translational Highlights for the Clinics and Treatment DOI Creative Commons
Giuseppe De Simone, Benedetta Mazza, Licia Vellucci

et al.

Antioxidants, Journal Year: 2023, Volume and Issue: 12(4), P. 975 - 975

Published: April 21, 2023

Schizophrenia is a worldwide mental illness characterized by alterations at dopaminergic and glutamatergic synapses resulting in global dysconnectivity within between brain networks. Impairments inflammatory processes, mitochondrial functions, energy expenditure, oxidative stress have been extensively associated with schizophrenia pathophysiology. Antipsychotics, the mainstay of pharmacological treatment all sharing common feature dopamine D2 receptor occupancy, may affect antioxidant pathways as well protein levels gene expression. Here, we systematically reviewed available evidence on antioxidants’ mechanisms antipsychotic action impact first- second-generation compounds functions stress. We further focused clinical trials addressing efficacy tolerability antioxidants an augmentation strategy treatment. EMBASE, Scopus, Medline/PubMed databases were interrogated. The selection process was conducted respect Preferred Reporting Items for Systematic Reviews Meta-Analyses (PRISMA) criteria. Several proteins involved cell viability, metabolism, regulation systems reported to be significantly modified differences drugs. Finally, cognitive psychotic symptoms patients schizophrenia, although only preliminary, results indicate that studies are warranted.

Language: Английский

Citations

17
Identifying plasma metabolic characteristics of major depressive disorder, bipolar disorder, and schizophrenia in adolescents DOI Creative Commons

Bangmin Yin,

Yuping Cai, Teng Teng

et al.

Translational Psychiatry, Journal Year: 2024, Volume and Issue: 14(1)

Published: March 26, 2024

Abstract Major depressive disorder (MDD), bipolar (BD), and schizophrenia (SCZ) are classified as major mental disorders together account for the second-highest global disease burden, half of these patients experience symptom onset in adolescence. Several studies have reported both similar unique features regarding risk factors clinical symptoms three disorders. However, it is still unclear whether or metabolic characteristics adolescents. We conducted a metabolomics analysis plasma samples from adolescent healthy controls (HCs) with MDD, BD, SCZ. identified differentially expressed metabolites between HCs. Based on metabolites, correlation analysis, pathway potential diagnostic biomarker identification were Our results showed significant changes metabolism HCs; most distinct observed SCZ patients. Moreover, differences BD shared those MDD SCZ, although profile was closer to that than Additionally, we responsible multiple pathways. The among found fatty acid, steroid-hormone, purine, nicotinate, glutamate, tryptophan, arginine, proline metabolism. Interestingly, significantly altered glycolysis, glycerophospholipid, sphingolipid SCZ; lysine, cysteine, methionine BD; phenylalanine, tyrosine, aspartate BD. Finally, five panels biomarkers MDD-HC, BD-HC, SCZ-HC, MDD-SCZ, BD-SCZ comparisons. findings suggest vary across psychiatric critical provide new clues molecular mechanisms

Language: Английский

Citations

8
Chronic stress dysregulates the Hippo/YAP/14-3-3η pathway and induces mitochondrial damage in basolateral amygdala in a mouse model of depression DOI Creative Commons
Yan Zhao, Yulong Chen,

Chi-Hua Guo

et al.

Theranostics, Journal Year: 2024, Volume and Issue: 14(9), P. 3653 - 3673

Published: Jan. 1, 2024

: Recent evidence highlights the pivotal role of mitochondrial dysfunction in mood disorders, but mechanism involved remains unclear. We studied whether Hippo/YAP/14-3-3η signaling pathway mediates abnormalities that result onset major depressive disorder (MDD) a mouse model.

Language: Английский

Citations

7
Biomarkers of bipolar disorder based on metabolomics: A systematic review DOI
Jin Chen, Nousayhah Amdanee,

Xiaowei Zuo

et al.

Journal of Affective Disorders, Journal Year: 2024, Volume and Issue: 350, P. 492 - 503

Published: Jan. 12, 2024

Language: Английский

Citations

6
Cerebrospinal fluid oxidative stress metabolites in patients with bipolar disorder and healthy controls: a longitudinal case-control study DOI Creative Commons
Ulla Knorr, Anja Hviid Simonsen, Peter Roos

et al.

Translational Psychiatry, Journal Year: 2019, Volume and Issue: 9(1)

Published: Nov. 28, 2019

Abstract Bipolar disorder (BD) is a mental characterized by recurrent relapses of affective episodes, cognitive impairment, illness progression, and reduced life expectancy. Increased systemic oxidatively generated nucleoside damage have been found in some neurodegenerative disorders BD. As the first, this naturalistic prospective, longitudinal follow-up case-control study investigated cerebrospinal fluid (CSF) oxidative stress markers 8-oxo-7,8-dihydroguanosine (8-oxoGuo) 8-oxo-7,8-dihydro-2′-deoxyguanosine (8-oxodG) that relate to RNA DNA damage, respectively. Patients with BD ( n = 86, 51% female) gender-and-age-matched healthy control individuals (HC; 44, 44% were evaluated at baseline (T0), during (T1) after new episode (T2), if it occurred, year (T3). Cerebrospinal urine analyzed using ultra-performance liquid chromatography–tandem mass spectrometry. CSF-8-oxoGuo was statistically significantly higher 18% p 0.003) versus HC T0, 22% 0) T3. had increased 15% 0.042) from T0 T3, 14% 0.021) T2 T3 patients, who experienced an follow-up. CSF-8-oxodG 26% 0.054) decreased 19% 0.041) did not show significant change one-year CSF urine-8-oxoGuo levels correlated moderately. In conclusion, marker 8-oxoGuo showed both state trait dependence stability HC. Central may be potential biomarker for

Language: Английский

Citations

47