Methods in enzymology on CD-ROM/Methods in enzymology, Journal Year: 2024, Volume and Issue: unknown, P. 29 - 46
Published: Dec. 5, 2024
Language: Английский
Molecules, Journal Year: 2025, Volume and Issue: 30(3), P. 505 - 505
Published: Jan. 23, 2025
Zearalenone (ZEA) is one of the common mycotoxins in feeds. ZEA and its metabolites have estrogen-like activity can competitively bind to estrogen receptors, causing reproductive dysfunction damage organs. The toxicity mechanism mainly inhibits antioxidant pathway enzyme activity, induces cell cycle arrest DNA damage, blocks process cellular autophagy produce toxic effects. In animal husbandry practice, when animals ingest ZEA-contaminated feed, it likely lead abortion females, abnormal sperm viability males with inflammatory reactions various organs, cancerous changes organs humans they contaminated products. this paper, we reviewed detail how oxidative by inducing generation reactive oxygen species (ROS) regulating expression genes related pathways, germ apoptosis through mitochondrial death receptor activates order induce autophagy. addition, molecular detoxification also explored aiming provide a new direction theoretical basis for development methods better reduce global pollution harm caused ZEA.
Language: Английский
Citations
1
Methods in enzymology on CD-ROM/Methods in enzymology, Journal Year: 2025, Volume and Issue: unknown
Published: Jan. 1, 2025
Language: Английский
Citations
0
Methods in enzymology on CD-ROM/Methods in enzymology, Journal Year: 2025, Volume and Issue: unknown
Published: Jan. 1, 2025
Language: Английский
Citations
0
Frontiers in Physiology, Journal Year: 2025, Volume and Issue: 16
Published: March 26, 2025
Atherosclerosis (AS), a prime causative factor in cardiovascular disease, originates from endothelial cell dysfunction (ECD). Comprising vital part of the vascular endothelium, cells play crucial role maintaining homeostasis, optimizing redox balance, and regulating inflammatory responses. More evidence shows that ECD not only serves as an early harbinger AS but also exhibits strong association with disease progression. In recent years, treatment strategies for have been continuously evolving, encompassing interventions ranging lifestyle modifications to traditional pharmacotherapy aimed at reducing risk factors, which demonstrated ability improve function. Additionally, novel such promising biotherapy gene therapy drawn attention. These methods enormous potential prospects improving function reversing AS. However, it is essential remain cognizant current treatments still present significant challenges regarding therapeutic efficacy, long-term safety, ethical issues. This article aims provide systematic review these methods, analyze mechanisms efficacy various strategies, goal offering insights guidance clinical practice, further advancing prevention diseases.
Language: Английский
Citations
0
bioRxiv (Cold Spring Harbor Laboratory), Journal Year: 2024, Volume and Issue: unknown
Published: Jan. 10, 2024
Protein translation is an energy-intensive ribosome-driven process that reduced during nutrient scarcity to conserve cellular resources. During prolonged starvation, cells selectively translate specific proteins enhance their survival (adaptive translation); however, this poorly understood. Accordingly, we analyzed protein and mRNA transcription by multiple methods in vitro vivo investigate adaptive hepatic starvation. While acute starvation suppressed general, proteomic analysis showed induced of lysosome autolysosome proteins. Significantly, the expression orphan nuclear receptor, estrogen-related receptor alpha (Esrra) increased served as a master regulator transcriptionally stimulating 60S acidic ribosomal P1 (Rplp1) gene expression. Overexpression or siRNA knockdown Esrra led parallel changes Rplp1 expression, lysosome/autophagy translation, autophagy. Remarkably, have found had dual functions not only regulating but also controlling via Esrra/Rplp1/lysosome/autophagy pathway
Language: Английский
Citations
1
Antioxidants and Redox Signaling, Journal Year: 2024, Volume and Issue: 40(16-18), P. 943 - 947
Published: April 4, 2024
Physical or chemical stress is commonly known to inhibit protein translation at the cellular level. Since process of requires catalysis by a multi-component machinery containing eukaryotic initiation factors (eIFs) and ribosomes in sequence reactions, how fails proceed whether certain genes can escape such blockade have provoked research efforts. Lines evidence demonstrated that phosphorylation eIF4E dephosphorylation 4E-binding proteins (4E-BPs) prevents formation factor 4F (eIF4F) complex, whereas 2 alpha (eIF2
Language: Английский
Citations
1
Stresses, Journal Year: 2024, Volume and Issue: 4(4), P. 827 - 849
Published: Dec. 2, 2024
Neurodegenerative diseases are devastating conditions with a rising incidence and prevalence due to the aging of population for which we currently do not have efficient therapies. Despite compelling evidence provided by basic research on involvement oxidative stress in their pathogenesis, most trials antioxidants failed. The reasons may relate low bioavailability used compounds or starting therapy late, when pathogenic cascades already induced irreversible damage. current review discusses sources central nervous system, reactive oxygen species pathogenesis Alzheimer’s disease, Parkinson’s amyotrophic lateral sclerosis, importance further improved delivery methods as well search biomarkers that could help early diagnosis hope finding more therapies these diseases.
Language: Английский
Citations
1
Methods in enzymology on CD-ROM/Methods in enzymology, Journal Year: 2024, Volume and Issue: unknown, P. 29 - 46
Published: Dec. 5, 2024
Language: Английский
Citations
0