Innovative nanoparticle-based approaches for modulating neutrophil extracellular traps in diseases: from mechanisms to therapeutics

Journal of Nanobiotechnology, Journal Year: 2025, Volume and Issue: 23(1)

Published: Feb. 6, 2025

Neutrophil extracellular traps (NETs) participate in both host defense and the pathogenesis of various diseases, such as infections, thrombosis, tumors. While they help capture eliminate pathogens, NETs' excessive or dysregulated formation can lead to tissue damage disease progression. Therapeutic strategies targeting NET modulation have shown potential, but challenges remain, particularly achieving precise drug delivery maintaining stability. Nanoparticle (NP)-based systems offer innovative solutions for overcoming limitations conventional therapies. This review explores biological mechanisms formation, their interactions with NPs, therapeutic applications NP-based modulating NETs. We discuss how NPs be designed either promote inhibit provide a comprehensive analysis potential treating NET-related diseases. Additionally, we address current future prospects therapies research, aiming bridge gap between nanotechnology development novel approaches.

Language: Английский

Harnessing potential role of gangliosides in immunomodulation and cancer therapeutics

Life Sciences, Journal Year: 2024, Volume and Issue: 351, P. 122786 - 122786

Published: June 5, 2024

Language: Английский