Phytochemicals regulate cancer metabolism through modulation of the AMPK/PGC-1α signaling pathway

BMC Cancer, Journal Year: 2024, Volume and Issue: 24(1)

Published: Sept. 2, 2024

Due to the complex pathophysiological mechanisms involved in cancer progression and metastasis, current therapeutic approaches lack efficacy have significant adverse effects. Therefore, it is essential establish novel strategies for combating cancer. Phytochemicals, which possess multiple biological activities, such as antioxidant, anti-inflammatory, antimutagenic, immunomodulatory, antiproliferative, anti-angiogenesis, antimetastatic properties, can regulate interfere various stages of development by suppressing signaling pathways. The systematic comprehensive review was conducted based on Preferred Reporting Items Systematic Reviews Meta-Analysis (PRISMA) criteria, using electronic databases, including PubMed, Scopus, Science Direct, until end December 2023. After excluding unrelated articles, 111 related articles were included this review. In review, major pathways metabolism are highlighted with promising anticancer role phytochemicals. This through their ability AMP-activated protein kinase (AMPK)/peroxisome proliferator-activated receptor-gamma coactivator-1α (PGC-1α) pathway. AMPK/PGC-1α pathway plays a crucial cell via targeting energy homeostasis mitochondria biogenesis, glucose oxidation, fatty acid thereby generating ATP growth. As result, may represent approach treatment. Accordingly, alkaloids, phenolic compounds, terpene/terpenoids, miscellaneous phytochemicals been introduced agents regulating Novel delivery systems also

Language: Английский

Synergistic Inhibition of Colon Cancer Cell Proliferation via p53, Bax, and Bcl-2 Modulation by Curcumin and Plumbagin Combination

ACS Omega, Journal Year: 2025, Volume and Issue: unknown

Published: April 29, 2025

Language: Английский