Angiotensin-Converting Enzyme-Dependent Intrarenal Angiotensin II Contributes to CTP: Phosphoethanolamine Cytidylyltransferase Downregulation, Mitochondrial Membranous Disruption, and Reactive Oxygen Species Overgeneration in Diabetic Tubulopathy

Antioxidants and Redox Signaling, Journal Year: 2024, Volume and Issue: unknown

Published: Nov. 4, 2024

Aims: The limited therapeutic options for diabetic tubulopathy (DT) in early kidney disease (DKD) reflect the difficulty of targeting renal tubular compartment. While renin–angiotensin–aldosterone system (RAS) inhibitors are commonly utilized management DKD, how intrarenal RAS contributes to injury is not fully understood. Mitochondrial disruption and reactive oxygen species (ROS) overgeneration have been involved injury. Herein, we aim test hypothesis that angiotensin-converting enzyme (ACE)-dependent angiotensin II (AngII) disrupts mitochondrial membranous homeostasis causes excessive ROS generation DT.

Language: Английский

SNX3 Promotes Doxorubicin-Induced Cardiomyopathy by Regulating GPX4-Mediated Ferroptosis

International Journal of Medical Sciences, Journal Year: 2024, Volume and Issue: 21(9), P. 1629 - 1639

Published: Jan. 1, 2024

The complete molecular mechanism underlying doxorubicin-induced cardiomyopathy remains incompletely elucidated. In this investigation, we engineered mice with cardiomyocyte-specific

Language: Английский

Micafungin protects mouse heart against doxorubicin-induced oxidative injury via suppressing MALT1-dependent k48-linked ubiquitination of Nrf2

Chemico-Biological Interactions, Journal Year: 2024, Volume and Issue: 400, P. 111179 - 111179

Published: July 31, 2024

Language: Английский