Essential roles of the unfolded protein response in intestinal physiology DOI Creative Commons
Claudio Hetz, Juan Francisco Silva-Agüero, Lisa Ellerby

et al.

eGastroenterology, Journal Year: 2024, Volume and Issue: 2(4), P. e100129 - e100129

Published: Dec. 1, 2024

The intestinal epithelium serves as an essential interface between the host and microbiota, regulating innate adaptive immunity, absorption of nutrients systemic metabolism, mediating bidirectional communication with nervous system. suffers constant challenges to proteostasis machinery due its exposure dynamically changing microbial laden lumenal gut environment high secretory demand placed on multiple epithelial cell types accommodate physiology-especially goblet, enteroendocrine Paneth cells. In all cases, cells require active unfolded protein response (UPR) sustain their physiological function, main pathway that monitors adjusts function changes in environment. A specialised endoplasmic reticulum (ER) stress sensor uniquely expressed lining mucosal surfaces, termed inositol-requiring transmembrane kinase/endoribonuclease β, has specific roles homeostasis, mucus production microbiota. Chronic ER or genetic mutations affecting key UPR mediators contribute occurrence inflammatory bowel disease ulcerative colitis, addition colon cancer. Here, we review recent advances linking physiology disease. Therapeutic strategies alleviate enforce improve ageing diseases are also discussed.

Language: Английский

Protein disulphide isomerase A4 as a potential biomarker for coronavirus disease 2019: Correlation with cytokine profiles and disease progression DOI Creative Commons

Yu-Hsiu Chang,

Ying‐Chuan Wang,

Yun-Chen Liu

et al.

Virulence, Journal Year: 2025, Volume and Issue: unknown

Published: May 20, 2025

This study investigated the role of protein disulphide isomerase A4 (PDIA4) in pathogenesis coronavirus disease 2019 (COVID-19), focusing on its relationship with severity and potential as a biomarker. We analysed cohort adult COVID-19 patients varying severity, grouped by vaccination status. Serum levels PDIA4 cytokines (interleukin [IL]-6, interferon gamma inducible protein-10 [IP-10], IL-16, monocyte chemoattractant protein-1 [MCP-1], platelet-derived growth factor-BB [PDGF-BB]) were measured using enzyme-linked immunosorbent assay compared among different severities. Statistical analyses performed to assess correlation between levels, inflammatory markers. Unvaccinated pneumonia had significantly higher than those without (517.94 ± 264 vs. 284.86 2.24; p = 0.0022). Although unvaccinated requiring oxygen support exhibited not (519.30 269.67 420.89 240.49; 0.4825), difference was statistically significant. No significant observed respiratory failure. Levels positively correlated MCP-1, IP-10, IL-6 (correlation coefficients: 0.28-0.62), although this weaker or absent vaccinated patients. Our findings suggest that is associated may serve biomarker progression. Further studies are needed elucidate mechanisms which influences immune response for therapeutic exploration COVID-19.

Language: Английский

Citations

0
Essential roles of the unfolded protein response in intestinal physiology DOI Creative Commons
Claudio Hetz, Juan Francisco Silva-Agüero, Lisa Ellerby

et al.

eGastroenterology, Journal Year: 2024, Volume and Issue: 2(4), P. e100129 - e100129

Published: Dec. 1, 2024

The intestinal epithelium serves as an essential interface between the host and microbiota, regulating innate adaptive immunity, absorption of nutrients systemic metabolism, mediating bidirectional communication with nervous system. suffers constant challenges to proteostasis machinery due its exposure dynamically changing microbial laden lumenal gut environment high secretory demand placed on multiple epithelial cell types accommodate physiology-especially goblet, enteroendocrine Paneth cells. In all cases, cells require active unfolded protein response (UPR) sustain their physiological function, main pathway that monitors adjusts function changes in environment. A specialised endoplasmic reticulum (ER) stress sensor uniquely expressed lining mucosal surfaces, termed inositol-requiring transmembrane kinase/endoribonuclease β, has specific roles homeostasis, mucus production microbiota. Chronic ER or genetic mutations affecting key UPR mediators contribute occurrence inflammatory bowel disease ulcerative colitis, addition colon cancer. Here, we review recent advances linking physiology disease. Therapeutic strategies alleviate enforce improve ageing diseases are also discussed.

Language: Английский

Citations

0