Analysis of Molecular Aspects of Periodontitis as a Risk Factor for Neurodegenerative Diseases: A Single-Center 10-Year Retrospective Cohort Study

International Journal of Molecular Sciences, Journal Year: 2025, Volume and Issue: 26(6), P. 2382 - 2382

Published: March 7, 2025

Neurodegenerative diseases (NDDs) represent a considerable global health burden with no definitive treatments. Emerging evidence suggests that periodontitis may contribute to NDD through shared inflammatory, microbial, and genetic pathways. A retrospective cohort design was applied analyze hospital records from 2012–2022 determine whether independently increases risk when accounting for major cardiovascular, cerebrovascular, metabolic, inflammatory confounders. Likelihood ratio-based Cox regression tests Weibull survival models were assess the association between risk. Model selection guided by Akaike Bayesian information criteria, while Harrell’s C-index receiver operating characteristic curves evaluated predictive performance. Periodontitis demonstrated an independent neurodegenerative disease (HR 1.43, 95% CI 1.02–1.99). Cerebral infarction conferred highest hazard 4.81, 2.90–7.96), pneumonia 1.96, 1.05–3.64) gastroesophageal reflux 2.82, 1.77–4.51) also showed significant in Older individuals are at heightened of disease, effect further intensified cardiometabolic, conditions. Pneumonia emerged as pathophysiological factor accelerate onset or progression. Attention oral systemic factors coordinated clinical management mitigate severity neurodegeneration.

Language: Английский

Visualize neuronal membrane cholesterol with split- fluorescent protein tagged YDQA sensor

Journal of Lipid Research, Journal Year: 2025, Volume and Issue: unknown, P. 100781 - 100781

Published: March 1, 2025

Language: Английский