Associations of Maternal Salivary Cortisol and Psychological Symptoms With Human Milk’s Microbiome Composition DOI

Nadia Deflorin,

Ulrike Ehlert, Rita T. Amiel Castro

et al.

Psychosomatic Medicine, Journal Year: 2024, Volume and Issue: 87(1), P. 33 - 45

Published: Dec. 20, 2024

ABSTRACT Objective Human milk (HM) is considered the best source of infant nutrition with many benefits for infant. However, pregnancy changes can lead to increased stress in some women, which might affect HM composition. Although studies have demonstrated a link between maternal psychopathology and child development, it remains unclear how psychobiological be intergenerationally transmitted. We aimed investigate associations stress, depressive symptoms, anxiety symptoms microbiome; analyze these parameters relation glucocorticoid concentrations; explore influence glucocorticoids on bacterial Methods One hundred women completed psychological questionnaires (e.g., EPDS, STAI, GAS) at 34–36 weeks’ gestation early postpartum period provided saliva 38 gestation. samples were collected postpartum. Microbiota analyzed using 16S rRNA amplicon sequencing. Results Birth was negatively correlated Alphaproteobacteria ( τ = −0.20, FDR 0.01), whereas period, different taxa. The sum postpartum-related linked lower Propionibacteriales. Salivary cortisol AUCg weeks Stenotrophomonas −0.24, 0.05), positively Streptococcus mitis 0.26, 0.03) Gemella haemolysans 0.24, 0.02). No emerged glucocorticoids. Conclusions Higher perinatal prenatal salivary associated relative abundances bacteria, higher Streptococcus. These findings suggest negative association high microbiota.

Language: Английский

Difference in the Intestinal Microbiota between Breastfeed Infants and Infants Fed with Artificial Milk: A Systematic Review DOI Creative Commons
Francesco Inchingolo, Angelo Michele Inchingolo, G Latini

et al.

Pathogens, Journal Year: 2024, Volume and Issue: 13(7), P. 533 - 533

Published: June 24, 2024

The gut microbiota (GM) plays a crucial role in human health, particularly during the first years of life. Differences GM between breastfed and formula (F)-fed infants may influence long-term health outcomes. This systematic review aims to compare with that F-fed evaluate clinical implications these differences. We searched databases on Scopus, Web Science, Pubmed following keywords: “gut microbiota”, microbiome”, “neonatal milk”. inclusion criteria were articles relating analysis intestinal microbiome newborns relation type nutrition, studies or case series, excluding reviews, meta-analyses, animal models, vitro studies. screening phase ended selection 13 publications for this work. Breastfed showed higher levels beneficial bacteria such as Bifidobacterium Lactobacillus, while had prevalence potentially pathogenic bacteria, including Clostridium difficile Enterobacteriaceae. Infant feeding influences composition oral significantly. Breastfeeding promotes healthier more diverse microbial ecosystem, which offer protective benefits. Future research should explore strategies improve understand implications.

Language: Английский

Citations

10
Bioactive compounds in human milk DOI
Anthony E. Castro, Maria Sanchez-Holgado, Miguel Sáenz de Pipaón

et al.

Current Opinion in Clinical Nutrition & Metabolic Care, Journal Year: 2025, Volume and Issue: unknown

Published: Feb. 12, 2025

Purpose of review: Human milk is the optimal food choice for infants. Reviewing latest advances in research about human compounds and their effect on health helps understand benefits breastfeeding improves knowledge key bioactive nutrients that can be used to improve feeding during infancy, with short long-time effects health. Recent findings: In last years, it has been described how such as oligosaccharides, hormones, lipids, cellular components microbes play an important role infants’ health, reducing risk infectious, metabolic autoimmune diseases. The mechanisms transmission from mother infant these are not always well described, but there several lines biological beneficial effects. Summary: These findings may help maternal interventions, modifiable factors able modulate composition. They development formulas enhance nutritional plans. Also, identification isolation describe new ways supplementation.

Language: Английский

Citations

0
Bioaktives Potenzial der Muttermilchernährung DOI

Antje Damms,

Daria Guseva,

Regina Ensenauer

et al.

Pädiatrie up2date, Journal Year: 2024, Volume and Issue: 19(03), P. 209 - 226

Published: Sept. 1, 2024

Citations

0
Associations of Maternal Salivary Cortisol and Psychological Symptoms With Human Milk’s Microbiome Composition DOI

Nadia Deflorin,

Ulrike Ehlert, Rita T. Amiel Castro

et al.

Psychosomatic Medicine, Journal Year: 2024, Volume and Issue: 87(1), P. 33 - 45

Published: Dec. 20, 2024

ABSTRACT Objective Human milk (HM) is considered the best source of infant nutrition with many benefits for infant. However, pregnancy changes can lead to increased stress in some women, which might affect HM composition. Although studies have demonstrated a link between maternal psychopathology and child development, it remains unclear how psychobiological be intergenerationally transmitted. We aimed investigate associations stress, depressive symptoms, anxiety symptoms microbiome; analyze these parameters relation glucocorticoid concentrations; explore influence glucocorticoids on bacterial Methods One hundred women completed psychological questionnaires (e.g., EPDS, STAI, GAS) at 34–36 weeks’ gestation early postpartum period provided saliva 38 gestation. samples were collected postpartum. Microbiota analyzed using 16S rRNA amplicon sequencing. Results Birth was negatively correlated Alphaproteobacteria ( τ = −0.20, FDR 0.01), whereas period, different taxa. The sum postpartum-related linked lower Propionibacteriales. Salivary cortisol AUCg weeks Stenotrophomonas −0.24, 0.05), positively Streptococcus mitis 0.26, 0.03) Gemella haemolysans 0.24, 0.02). No emerged glucocorticoids. Conclusions Higher perinatal prenatal salivary associated relative abundances bacteria, higher Streptococcus. These findings suggest negative association high microbiota.

Language: Английский

Citations

0