Sex Differences in the Acute Effects of Oral THC: A Randomized, Placebo-Controlled, Crossover Human Laboratory Study DOI Creative Commons
Ardavan Mohammad Aghaei,

Lia Urban Spillane,

Brian Pittman

et al.

medRxiv (Cold Spring Harbor Laboratory), Journal Year: 2023, Volume and Issue: unknown

Published: Nov. 29, 2023

Recent reports have shown increased cannabis use among women, leading to growing concerns about disorder (CUD). Some evidence suggests a faster progression addiction in known as the "telescoping effect." While there is preclinical suggesting biological sex influences cannabinoid effects, human research remains scant. We investigated differences response oral tetrahydrocannabinol (THC) humans.

Language: Английский

Enhancing translation: A need to leverage complex preclinical models of addictive drugs to accelerate substance use treatment options DOI Creative Commons

Christa Corley,

Ashley Craig, Safiyah Sadek

et al.

Pharmacology Biochemistry and Behavior, Journal Year: 2024, Volume and Issue: 243, P. 173836 - 173836

Published: July 26, 2024

Preclinical models of addictive drugs have been developed for decades to model aspects the clinical experience in substance use disorders (SUDs). These include passive exposure as well volitional intake across and utilized also measure withdrawal symptomatology potential neurobehavioral mechanisms underlying relapse drug seeking or taking. There are a number Food Drug Administration (FDA)-approved medications SUDs, however, many demonstrate low efficacy sex differences, we note gaps continuum care certain experiences individuals who drugs. In this review, provide comprehensive update on both frequently novel behavioral addiction with focus translational value highlight need preclinical research follow epidemiological trends patterns stay abreast treatment needs. We then areas which could be improved enhance development pipeline through efforts translation models. Next, describe neuroscience that can leveraged identify biological focusing specifically advances brain transcriptomics approaches screening identification targets. Together, confluence review demonstrates careful selection methodological parameters better approximate combined cutting edge techniques advance SUDs.

Language: Английский

Citations

5
Potential roles for microglia in drug addiction: Adolescent neurodevelopment and beyond DOI
Maricela X. Martinez, Stephen V. Mahler

Journal of Neuroimmunology, Journal Year: 2025, Volume and Issue: unknown, P. 578600 - 578600

Published: March 1, 2025

Language: Английский

Citations

0
Nonneuronal contributions to synaptic function DOI
Ritchy Hodebourg, Michael D. Scofield, Peter W. Kalivas

et al.

Neuron, Journal Year: 2025, Volume and Issue: unknown

Published: April 1, 2025

Language: Английский

Citations

0
Adolescent THC impacts on mPFC dopamine-mediated cognitive processes in male and female rats DOI Creative Commons
Maricela X. Martinez, Vanessa Alizo Vera, Christina M. Ruiz

et al.

bioRxiv (Cold Spring Harbor Laboratory), Journal Year: 2024, Volume and Issue: unknown

Published: April 15, 2024

Abstract Rationale Adolescent cannabis use is linked to later-life changes in cognition, learning, and memory. Rodent experimental studies suggest Δ 9 -tetrahydrocannabinol (THC) influences development of circuits underlying these processes, especially the prefrontal cortex, which matures during adolescence. Objective We determined how 14 daily THC injections (5mg/kg) adolescence persistently impacts medial cortex (mPFC) dopamine-dependent cognition. Methods In adult Long Evans rats treated as adolescents with (AdoTHC), we quantify performance on two mPFC reward-based tasks—strategy set shifting probabilistic discounting. also acute dopamine augmentation amphetamine (0, 0.25, 0.5 mg/kg), or specific chemogenetic stimulation ventral tegmental area (VTA) neurons their projections Results AdoTHC sex-dependently acquisition cue-guided instrumental reward seeking, but has minimal effects set-shifting discounting either sex. When challenged acutely discounting, found reduced improbable options, being more sensitive than controls. contrast, neither VTA nor pathway-specific projection impacted control rats, although this cortical slightly disrupted choices rats. Conclusions These confirm a marked specificity cognitive processes by exposure. They that some persistent may alter amphetamine-induced manner independent mPFC.

Language: Английский

Citations

1
Sex Differences in the Acute Effects of Oral THC: A Randomized, Placebo-Controlled, Crossover Human Laboratory Study DOI Creative Commons
Ardavan Mohammad Aghaei,

Lia Urban Spillane,

Brian Pittman

et al.

medRxiv (Cold Spring Harbor Laboratory), Journal Year: 2023, Volume and Issue: unknown

Published: Nov. 29, 2023

Recent reports have shown increased cannabis use among women, leading to growing concerns about disorder (CUD). Some evidence suggests a faster progression addiction in known as the "telescoping effect." While there is preclinical suggesting biological sex influences cannabinoid effects, human research remains scant. We investigated differences response oral tetrahydrocannabinol (THC) humans.

Language: Английский

Citations

2