Therapeutic potential of CBD in Autism Spectrum Disorder
International review of neurobiology,
Journal Year:
2024,
Volume and Issue:
unknown, P. 149 - 203
Published: Jan. 1, 2024
Language: Английский
Cannabinoid Pharmaceutical Science: Laying the Foundation for Cannabis Therapeutics
Leah Sera,
No information about this author
Carrie Hempel‐Sanderoff
No information about this author
Published: Jan. 1, 2025
Language: Английский
Epidemiology and Health Impacts of Substance Use
Published: Jan. 1, 2025
Language: Английский
Challenges of Extracting and Determining Cannabinoids in Different Matrices
Cannabis and Cannabinoid Research,
Journal Year:
2024,
Volume and Issue:
9(6), P. 1470 - 1477
Published: Aug. 13, 2024
Introduction:
Accurate
and
precise
analysis
of
cannabinoids
is
important
for
elucidating
their
therapeutic
potential
developing
therapies,
which
are
targeted
toward
different
medical
conditions.
A
wide
range
cannabis
products
present
on
the
market
available
in
dosage
forms,
including
dried
flowers,
extracts,
consumables.
The
aim
this
article
to
provide
an
updated
narrative
review
literature
challenges
analyzing
plant
material,
oils,
edibles.
Language: Английский
Effects of Water and Wind Stress on Phytochemical Diversity, Cannabinoid Composition, and Arthropod Diversity in Hemp
Plants,
Journal Year:
2025,
Volume and Issue:
14(3), P. 474 - 474
Published: Feb. 5, 2025
Phytochemical
diversity
is
increasingly
appreciated
as
an
important
attribute
of
plants
that
affects
their
interactions
with
other
organisms
and
can
have
substantial
effects
on
arthropod
communities,
but
this
axis
less
studied
for
agricultural
plants.
For
both
managed
natural
systems,
understanding
how
extreme
weather
events,
such
droughts,
floods,
wind,
affect
phytochemical
part
predicting
responses
plant–arthropod
to
climate
change.
In
outdoor
field
experiment
two
distinct
varieties
hemp
(Cannabis
sativa
L.,
Cannabaceae),
we
investigated
the
simulated
water
stress
from
reduced
availability
flooding,
along
unplanned
wind
event
cannabinoid
profiles.
We
also
examined
changes
in
chemistry
affected
associated
arthropods.
Our
results
indicate
genetic
variety
environmental
variation
composition,
these
cascaded
alter
communities
flowers.
The
largest
differences
were
found
between
different
varieties,
which
accounted
over
10%
diversity.
Stress
floods
flowers,
had
negative
cannabidiol
(CBD)
concentrations,
deficit
flooding
caused
subtle
shifts
composition.
subsequent
cascading
depended
it
was
characterized,
increases
CBD
causing
higher
richness,
while
increased
These
provide
insights
into
potential
chemistry,
well
consequences
colonizing
Language: Английский
Beyond Cannabidiol: The Contribution of Cannabis sativa Phytocomplex to Skin Anti-Inflammatory Activity in Human Skin Keratinocytes
Pharmaceuticals,
Journal Year:
2025,
Volume and Issue:
18(5), P. 647 - 647
Published: April 28, 2025
Background:
Cannabis
sativa
L.
(C.
sativa)
has
a
long
history
of
medicinal
use.
Its
inflorescences
contain
bioactive
compounds
like
non-psychotropic
cannabidiol
(CBD),
which
is
well
known
for
its
anti-inflammatory
potential
in
skin
conditions
such
as
psoriasis,
and
psychotropic
Δ-9-tetrahydrocannabinol
(THC).
Keratinocytes,
the
main
cells
epidermis,
are
crucial
regulating
inflammation
by
producing
mediators
IL-8
when
stimulated
agents
TNFα.
Methods:
This
study
explores
effects
standardized
C.
extract
(CSE)
with
5%
CBD
less
than
0.2%
THC
human
keratinocytes
challenged
The
aim
this
to
analyze
specific
contributions
constituents
CSE
inflammatory
responses
fractionating
examining
individual
components.
Results:
MTT
assays
showed
that
was
non-toxic
HaCaT
up
50
μg/mL.
inhibited
NF-κB
activity
reduced
secretion
concentration-dependent
manner,
mean
IC50
values
28.94
±
10.40
μg/mL
20.06
2.78
(mean
SEM),
respectively.
Fractionation
into
four
subfractions
revealed
more
lipophilic
fractions
(A
B)
were
most
effective
inhibiting
NF-κB,
indicating
cannabinoids
cannflavins
key
contributors.
Pure
one
active
reducing
NF-κB-driven
transcription
(together
cannabigerol),
due
abundance
CSE,
it
primarily
responsible
activity.
Conclusions:
highlights
CBD’s
significant
role
underscores
need
consider
synergistic
interactions
several
molecules
within
extracts
maximum
efficacy.
Standardized
essential
reproducible
results
variability
responses.
Language: Английский
Medicinal cannabis for treating post-traumatic stress disorder and comorbid depression: real-world evidence
BJPsych Open,
Journal Year:
2024,
Volume and Issue:
10(2)
Published: March 1, 2024
Background
Cannabis-based
medicinal
products
(CBMPs)
are
increasingly
being
used
to
treat
post-traumatic
stress
disorder
(PTSD),
despite
limited
evidence
of
their
efficacy.
PTSD
is
often
comorbid
with
major
depression,
and
little
known
about
whether
depression
alters
the
effectiveness
CBMPs.
Aims
To
document
prevalence
among
individuals
seeking
CBMPs
examine
varies
by
status.
Method
Data
were
available
for
238
people
CBMP
treatment
(5.9%
treatment-seeking
sample)
3-month
follow-up
data
116
these.
Self-reported
symptoms
assessed
at
entry
using
Checklist
–
Civilian
Version
(PCL-C).
The
probable
presence
was
nine-item
Patient
Health
Questionnaire
(PHQ-9).
Additional
included
sociodemographic
characteristics
self-reported
quality
life.
Results
In
total,
77%
met
screening
criteria
which
associated
higher
levels
symptomatology
(mean
67.8
v.
48.4,
F
(1,236)
=
118.5,
P
<
0.001)
poorer
general
health,
life
sleep.
reduced
substantially
3
months
after
commencing
58.0
47.0,
(1,112)
14.5,
0.001),
a
significant
interaction
(
6.2,
0.05)
indicating
greater
improvement
in
those
difference
15.3)
than
without
7).
Conclusions
Depression
common
symptom
severity
Effectiveness
treating
does
not
appear
be
impaired
depression.
Language: Английский
Research and Clinical Practice Involving the Use of Cannabis Products, with Emphasis on Cannabidiol: A Narrative Review
Pharmaceuticals,
Journal Year:
2024,
Volume and Issue:
17(12), P. 1644 - 1644
Published: Dec. 6, 2024
Background:
Emerging
evidence
supports
cannabidiol
(CBD)
as
a
promising
therapeutic
compound
for
various
health
conditions,
despite
its
approval
medication
(product
medical
purposes)
remaining
restricted
to
limited
range
of
clinical
indications.
Simultaneously,
the
regulation
cannabis-derived
products
medicinal
and
recreational
use
has
expanded
their
global
market
availability
meet
local
community
demands.
This
scenario
presents
complex
challenge
clinicians,
researchers,
industry,
appeal
uses
CBD
is
growing
more
rapidly
than
scientific
supporting
safety
effectiveness.
Outcomes:
A
narrative
review
was
conducted
discuss
best
regarding
pharmacological
profile
CBD,
efficacy,
within
context
perspectives
on
development
new
cannabinoid-based
drugs.
Key
articles
addressing
facets
this
issue
were
selected
comprehensive
analysis.
Conclusions:
Clinicians
researchers
may
face
unique
challenges
in
understanding
prospects
developing
indications,
given
heterogeneity
terminologies
quality
composition
cannabis-based
available
market.
More
basic
research
that
complies
with
regulatory
agencies’
testing
guidelines,
such
good
manufacturing
practices
(GMPs),
laboratory
(GLPs),
(GCPs),
needed
obtain
or
any
other
cannabinoid
broader
Language: Английский
Cannabidiol in anxiety disorders: Current and future perspectives
International review of neurobiology,
Journal Year:
2024,
Volume and Issue:
unknown, P. 205 - 234
Published: Jan. 1, 2024
Language: Английский
Cannabis Science and Therapeutics: An Overview for Clinicians
Leah Sera,
No information about this author
Carrie Hempel‐Sanderoff
No information about this author
The Journal of Clinical Pharmacology,
Journal Year:
2023,
Volume and Issue:
64(5), P. 499 - 513
Published: Dec. 25, 2023
Cannabis-based
therapeutics
have
garnered
increasing
attention
in
recent
years
as
patients
seek
alternative
treatments
for
various
medical
conditions.
This
narrative
review
provides
a
comprehensive
overview
of
the
science
behind
use
cannabis,
focusing
on
evidence
commonly
treated
In
addition,
addresses
practical
considerations
using
cannabis
therapeutic
agent,
offering
insights
into
dosing
strategies,
variations
cannabinoid
formulation,
and
individual
patient
responses.
Precautions,
adverse
consequences,
drug
interactions
are
also
discussed,
with
focus
safety
potential
risks
associated
use.
Language: Английский