Meta-analysis of FTO expression on the clinicopathologic characteristics and prognosis of gastric cancer DOI Creative Commons
Ciba Zhu, Mingxu Da,

Ziyao Wu

et al.

Medicine, Journal Year: 2024, Volume and Issue: 103(39), P. e35714 - e35714

Published: Sept. 27, 2024

Background: Fat mass and obesity-related gene (FTO) is aberrantly expressed in various cancers including highly gastric cancer tissues. The aim of this meta-analysis was to explore the effect FTO expression on clinicopathological prognostic outcome cancer. Methods: China National Knowledge Infrastructure (CNK), Wanfang database, VIP Chinese biomedical literature database (CBM), PubMed, Web Science, Cochrane library EMBASE were searched screen literatures according inclusion criteria. search time establishment until May 2023. two researchers independently screened literature, extracted pathological data, conducted Newcastle–Ottawa scale (NOS) quality evaluation. Analyze correlation between indicators patients impact prognosis, use Stata 12.0, software for Meta-analysis. Results: A total 1619 studied study. results Meta-analysis showed that higher levels associated with TMN stage (OR = 1.83, 95% CI: 1.11–3.03, P .019), liver metastases 3.73, 1.49–9.31, .005), vascular invasion 2.22, 1.36–3.61, .001), poorer overall survival (OS) (HR 0.46, 0.34–0.58, < .001) recurrence-free 0.56, 0.40–0.73, patients. There no significant relationship degree differentiation 1.08, 0.49–2.35, .852), age 0.89, 0.71–1.11, .306), gender 0.92, 0.74–1.14, .432). Conclusion: High risk distant poor prognosis may be a potential biomarker cancer, but due limited number above need further research.

Language: Английский

Demethylases in tumors and the tumor microenvironment: Key modifiers of N6-methyladenosine methylation DOI Creative Commons

Junchen Guo,

Liang Zhao,

Meiqi Duan

et al.

Biomedicine & Pharmacotherapy, Journal Year: 2024, Volume and Issue: 174, P. 116479 - 116479

Published: March 26, 2024

RNA methylation modifications are widespread in eukaryotes and prokaryotes, with N

Language: Английский

Citations

5
Hotspots and trends in gastric cancer stem cell research: a visualization and bibliometric analysis DOI Creative Commons
Jinfeng Liu, Xiaoxu Han,

Qingyi Wang

et al.

Frontiers in Oncology, Journal Year: 2025, Volume and Issue: 15

Published: March 5, 2025

Gastric cancer (GC) is a type of malignant tumor that seriously endangers human health. As the understanding mechanisms underlying gastric deepens, in recent years, investigations on stem cells (GCSCs) have garnered significant interest. They are pivotal onset, progression, recurrence, and pharmacoresistance GC. Comprehensive research GCSCs expected to provide new strategies for diagnosis treatment This article endeavors comprehensively assess current status future trends through bibliometric analysis, thereby providing valuable reference further - depth studies this field. English language academic journals related Web Science database were retrieved. Subsequently, VOSviewer was utilized conduct network collinear analysis exported source institutions, literature authors, references, keywords. And CiteSpace used perform statistical annual publication count, keyword clustering, burst. A total 3882 documents met criteria incorporated. The quantity published papers has shown consistent upward trend annually since 2003. Among authors literature, multiple stable core author groups represented by Zhu, Wei, Wang, Mei, Xu, Wenrong, etc. been formed. There 335 associated institutions total. Japan National Cancer Center strongest relevance largest number papers. 7 clustering labels formed among keywords, including main modules such as activation, cells, DNA content aneuploidy, expression. 25 burst keywords generated, past two years include mesenchymal drug resistance, proliferation, emergence references indicates eight cited up now focus research. overview 30 visually presented visual maps. In decade, scholars' field gradually intensified, development good. Through deeper study mechanism, intervention will be promising approach GC patients. hot topic still deserves more attention future.

Language: Английский

Citations

0
FTO promotes gastric cancer progression by modulating MAP4K4 expression via demethylation in an m6A-dependent manner DOI
Zhe Yin, Xiong Guo, Xiaolong Liang

et al.

Medical Oncology, Journal Year: 2024, Volume and Issue: 41(5)

Published: April 20, 2024

Language: Английский

Citations

0
Meta-analysis of FTO expression on the clinicopathologic characteristics and prognosis of gastric cancer DOI Creative Commons
Ciba Zhu, Mingxu Da,

Ziyao Wu

et al.

Medicine, Journal Year: 2024, Volume and Issue: 103(39), P. e35714 - e35714

Published: Sept. 27, 2024

Background: Fat mass and obesity-related gene (FTO) is aberrantly expressed in various cancers including highly gastric cancer tissues. The aim of this meta-analysis was to explore the effect FTO expression on clinicopathological prognostic outcome cancer. Methods: China National Knowledge Infrastructure (CNK), Wanfang database, VIP Chinese biomedical literature database (CBM), PubMed, Web Science, Cochrane library EMBASE were searched screen literatures according inclusion criteria. search time establishment until May 2023. two researchers independently screened literature, extracted pathological data, conducted Newcastle–Ottawa scale (NOS) quality evaluation. Analyze correlation between indicators patients impact prognosis, use Stata 12.0, software for Meta-analysis. Results: A total 1619 studied study. results Meta-analysis showed that higher levels associated with TMN stage (OR = 1.83, 95% CI: 1.11–3.03, P .019), liver metastases 3.73, 1.49–9.31, .005), vascular invasion 2.22, 1.36–3.61, .001), poorer overall survival (OS) (HR 0.46, 0.34–0.58, < .001) recurrence-free 0.56, 0.40–0.73, patients. There no significant relationship degree differentiation 1.08, 0.49–2.35, .852), age 0.89, 0.71–1.11, .306), gender 0.92, 0.74–1.14, .432). Conclusion: High risk distant poor prognosis may be a potential biomarker cancer, but due limited number above need further research.

Language: Английский

Citations

0