More on the interplay between gut microbiota, autophagy, and inflammatory bowel disease is needed

World Journal of Gastroenterology, Journal Year: 2024, Volume and Issue: 30(27), P. 3356 - 3360

Published: July 11, 2024

The concept of inflammatory bowel disease (IBD), which encompasses Crohn's and ulcerative colitis, represents a complex growing global health concern resulting from multifactorial etiology. Both dysfunctional autophagy dysbiosis contribute to IBD, with their combined effects exacerbating the related condition. As result, existing interconnection between gut microbiota, autophagy, host's immune system is decisive factor in occurrence IBD. factors that influence microbiota impact are another important point this regard. Based on initial perspective, manuscript briefly highlighted intricate interplay IBD pathogenesis. In addition, it also addressed potential targeting modulating autophagic pathways for therapy proposed suggestions future research within more specific expanded context. Further studies warranted explore restoring microbial balance regulating mechanisms, may offer new therapeutic avenues management delve into personalized treatment alleviate burden.

Language: Английский

Gut Microbial Targets in Inflammatory Bowel Disease: Current Position and Future Developments

Biomedicines, Journal Year: 2025, Volume and Issue: 13(3), P. 716 - 716

Published: March 14, 2025

Inflammatory bowel disease (IBD) is a debilitating condition in which surgery often seen as last resort. However, this associated with morbidity and, some cases, mortality. There are emerging therapies that seek to better modulate the immune response of hosts IBD. Aims: The main aim study focus on novel and techniques studied year non-surgical treatments Methods: We looked at all research between March 2024 February 2025 detailing treatment IBD focused gut microbiome gene therapy. Results: Novel gaining traction safety popularity. results from animal studies show promise FDA approval, probiotic optimistic potential for future human trials. Conclusions: into diagnostics available horizon humans very promising. Animal have shown potentially transferrable safe can target specific sites inflammation. Modulating inflammatory powerful therapy what be reasonably profile build further on.

Language: Английский

Comparing the Diagnostic Value of FDG PET or PET/CT With FDG PET/MR in Inflammatory Bowel Disease—A Systematic Review and Meta-analysis

Clinical Nuclear Medicine, Journal Year: 2024, Volume and Issue: 49(10), P. e492 - e500

Published: July 5, 2024

The aim of this study was to compare the diagnostic value 18 F-FDG PET or PET/CT with FDG PET/MR in patients inflammatory bowel disease (IBD).

Language: Английский