The Impact of Liver Steatosis on Interleukin and Growth Factors Kinetics during Chronic Hepatitis C Treatment DOI Open Access
Leona Radmanić, Snježana Židovec Lepej,

Nikolina Salek

et al.

Journal of Clinical Medicine, Journal Year: 2024, Volume and Issue: 13(16), P. 4849 - 4849

Published: Aug. 16, 2024

Background/Objectives: Various biological response modifiers play important roles in the immunopathogenesis of chronic hepatitis C (CHC). While serum levels cytokines and growth factors change with disease severity treatment responses, impact concomitant liver steatosis on systemic inflammatory is largely unknown. The aim this study was to analyze characteristics kinetics profiles interleukins CHC patients steatotic (SLD). Methods: Serum concentrations 12 (IL-5, IL-13, IL-2, IL-6, IL-9, IL-10, IFN-γ, TNF-α, IL-17A, IL-17F, IL-4 IL-22) 6 (Angiopoietin-2, EGF, EPO, HGF, SCF, VEGF) were analyzed 56 at four time points (baseline, week 4, 8 SVR12) bead-based flow cytometry assay. Results: At baseline, SLD had significantly lower IL-13 IL-22 higher VEGF ANG. In a subgroup advanced fibrosis, linked IL-4, IL-5, HGH VEGF. Distinct cytokine during DAA observed, identified as main source variation for IL-22, Patients SVR12 HGF concentrations. Conclusions: associated distinct factor treatment, which might be capacity regeneration contribute fibrosis persistence.

Language: Английский

CCL19/MIP-3β as a key mediator in the production of anti-GPIIb/IIIa antibody-producing B cells in patients with chronic hepatitis C DOI

J Iida,

Haruki Uojima, Takashi Satoh

et al.

Cytokine, Journal Year: 2025, Volume and Issue: 190, P. 156915 - 156915

Published: March 19, 2025

Language: Английский

Citations

0
Research and Advances on Langerhans Cell Histiocytosis-Related Liver Injury DOI

丽莉 张

Advances in Clinical Medicine, Journal Year: 2025, Volume and Issue: 15(04), P. 2650 - 2657

Published: Jan. 1, 2025

Language: Английский

Citations

0
HLA-F expression on CD4 T cells in HIV-1 is linked to the presence of viremia and modulated by KIR3DS1 DOI Creative Commons

Angelique Hœlzemer,

Timo Trenkner,

Sébastien Brias

et al.

Research Square (Research Square), Journal Year: 2025, Volume and Issue: unknown

Published: March 25, 2025

Abstract KIR3DS1 is an activating natural killer (NK) cell receptor gene– present in 10-40% of humans– and associated with extended AIDS-free survival. Although its ligand HLA-F has been identified, the underlying protective mechanism HIV-1 not yet understood. We sought to uncover role KIR3DS1/HLA-F axis through investigating surface transcriptional changes during acute chronic infection. HLA-F+ CD4 T cells were detected people living HIV (PLHIV) without antiretroviral treatment (N=102) frequencies correlated viremia but count. Single-cell transcriptome analyses PLHIV following acquisition revealed increased mRNA levels innate signaling signatures. In vitro, was upregulated both HIV-1–infected bystander cells. Functional studies demonstrated that bystander-activated reduced presence NK infection, depleting frequency Genotyping our cohort KIR3DS1+ exhibited significantly lower Taken together, these results establish as a novel marker activation linked suggest immunoregulatory controlling HIV-1-mediated inflammation by killing activated

Language: Английский

Citations

0
The Impact of Liver Steatosis on Interleukin and Growth Factors Kinetics during Chronic Hepatitis C Treatment DOI Open Access
Leona Radmanić, Snježana Židovec Lepej,

Nikolina Salek

et al.

Journal of Clinical Medicine, Journal Year: 2024, Volume and Issue: 13(16), P. 4849 - 4849

Published: Aug. 16, 2024

Background/Objectives: Various biological response modifiers play important roles in the immunopathogenesis of chronic hepatitis C (CHC). While serum levels cytokines and growth factors change with disease severity treatment responses, impact concomitant liver steatosis on systemic inflammatory is largely unknown. The aim this study was to analyze characteristics kinetics profiles interleukins CHC patients steatotic (SLD). Methods: Serum concentrations 12 (IL-5, IL-13, IL-2, IL-6, IL-9, IL-10, IFN-γ, TNF-α, IL-17A, IL-17F, IL-4 IL-22) 6 (Angiopoietin-2, EGF, EPO, HGF, SCF, VEGF) were analyzed 56 at four time points (baseline, week 4, 8 SVR12) bead-based flow cytometry assay. Results: At baseline, SLD had significantly lower IL-13 IL-22 higher VEGF ANG. In a subgroup advanced fibrosis, linked IL-4, IL-5, HGH VEGF. Distinct cytokine during DAA observed, identified as main source variation for IL-22, Patients SVR12 HGF concentrations. Conclusions: associated distinct factor treatment, which might be capacity regeneration contribute fibrosis persistence.

Language: Английский

Citations

0