An updated review on the phytochemistry and pharmacological activity of black cumin (Nigella sativa L.)
Advanced Chinese Medicine,
Journal Year:
2025,
Volume and Issue:
unknown
Published: March 23, 2025
Abstract
In
this
review,
a
comprehensive
and
systematic
evaluation
of
the
phytochemical
constituents,
traditional
medicinal
applications,
current
pharmacological
research,
toxicity,
nanobiotechnology
black
cumin
has
been
undertaken.
An
exhaustive
database
retrieval
was
conducted
to
collect
scientific
information
about
Nigella
sativa
L.
from
1956
2025
using
PubMed,
Scopus,
ISI
Web
Science,
SciFinder,
CABI.
Search
carried
out
keywords
“
,”
oil,”
“Ethnobotany,”
“Phytochemistry,”
“Pharmacological
activity,”
“Toxicity,”
“Nanotechnology.”
Several
important
phytochemicals
are
found
in
seeds
N
.
L.,
many
which
seem
have
good
impact
on
human
health
put
use
Ayurvedic,
Unani,
Siddha
systems
medicine.
Among
active
compounds,
thymoquinone
is
most
important,
forming
30%–48%
oil
fraction.
Besides
thymoquinone,
wide
range
such
as
thymohydroquinone,
dithymoquinone,
p
‐cymene,
sabinene,
carvacrol,
4‐terpineol,
kaempferol
(glucoside)
t
‐anethol,
longifolene
(sesquiterpene),
α
‐pinene,
‐hederin
(pentacyclic
triterpene),
thymol
also
reported.
Current
research
provided
evidence
for
uses
cumin,
especially
antioxidant,
anti‐inflammatory,
antibacterial,
antifungal,
antiviral,
anticancer,
antidiabetic,
neuroprotective,
gastroprotective,
antiarthritic
effects.
The
review
provides
an
in‐depth
analysis
phytochemistry,
well
potential
properties
Since
plant
being
extensively
investigated
its
properties,
valuable
up‐to‐date
status
will
act
reference
future
applications
plant.
Language: Английский
The Transformative Role of Nanotechnology in the Management of Diabetes Mellitus: Insights from Current Research
Biomolecules,
Journal Year:
2025,
Volume and Issue:
15(5), P. 653 - 653
Published: May 1, 2025
Nanotechnology
refers
to
the
science
that
modulates
molecules
nanoscale
dimension.
Nanomedicine,
i.e.,
utilization
of
nanotechnology
for
diagnosing
and
treating
several
disorders,
is
a
subject
ongoing
research.
The
concept
behind
nanomedicine
in
diabetes
mellitus
(DM)
treatment
stems
from
need
ameliorate
absorption
distribution
antidiabetic
therapies
order
overcome
barriers,
namely
pH
throughout
gastrointestinal
tract,
gut
microbiota,
temperature/heat
difficulties
incorporation
drugs
into
cells.
Thus,
scope
particularly
challenging
demanding,
considering
fact
human
body
perpetually
changing
entity
achieve
homeostasis.
In
this
review,
we
will
delve
various
nanoparticles
are
being
studied
terms
treatment,
their
pros
cons
expanding
knowledge
field.
Despite
seems
be
very
promising,
there
still
many
gaps
our
understanding
how
addresses
its
utilization.
Moreover,
high
costs,
along
with
an
as-yet
unclear
safety
profile,
remain
significant
barrier
widespread
adoption.
describe
both
phytochemicals
chemical
compounds
seeks
exploit
pave
way
more
efficacious
comprehensive
management
mellitus.
Language: Английский