Antimicrobial Properties of Hive Products and Their Potential Applications in Human and Veterinary Medicine

Antibiotics, Journal Year: 2025, Volume and Issue: 14(2), P. 172 - 172

Published: Feb. 10, 2025

Hive products, encompassing honey, propolis, bee venom, royal jelly, and pollen, are recognized for their antimicrobial therapeutic properties. This review examines chemical composition, explores mechanisms of action, discusses potential applications in both human veterinary medicine, particularly addressing the challenge resistance. study utilized a comprehensive literature search strategy, gathering data from Google Scholar, MEDLINE PubMed, SciELO, SCOPUS databases. Relevant terms were employed to ensure thorough retrieval pertinent literature. Honey, rich bioactive compounds such as hydrogen peroxide methylglyoxal, effectively disrupts biofilms combats multi-drug-resistant pathogens, showing promise treating range infections. Propolis, with its flavonoids phenolic acids, demonstrates synergistic effects when used conjunction antibiotics. Bee component melittin, exhibits antibacterial immunomodulatory properties, although further research is needed address toxicity concerns. Pollen jelly demonstrate broad-spectrum activity, which relevant animal health. Existing pre-clinical clinical support these hive products. products represent vast largely untapped natural resource combating resistance developing sustainable therapies, field medicine. However, challenges remain due inherent variability composition lack standardized protocols preparation application. Further essential fully elucidate optimize formulations enhanced efficacy, establish safe effective use.

Language: Английский

Kaempferol Mitigates Pseudomonas aeruginosa-Induced Acute Lung Inflammation Through Suppressing GSK3β/JNK/c-Jun Signaling Pathway and NF-κB Activation

Pharmaceuticals, Journal Year: 2025, Volume and Issue: 18(3), P. 322 - 322

Published: Feb. 25, 2025

Background: Pseudomonas aeruginosa, one of the common bacterial pathogens causing nosocomial pneumonia, is characterized as highly pathogenic and multidrug-resistant. Kaempferol (KP), a natural flavonoid, has been shown to exhibit effectiveness in treating infection-induced lung injury. Methods: We applied network pharmacology explore underlying mechanisms KP P. aeruginosa pneumonia further validated them through mouse model acute infection an vitro macrophage model. Results: The vivo studies demonstrated that treatment with suppressed production proinflammatory cytokines, including TNF, IL-1β, IL-6, MIP-2, attenuated neutrophil infiltration lesions lungs, leading increased survival rate mice. Further revealed enhanced phosphorylation GSK3β at Ser9 diminished JNK, c-Jun, NF-κB p65 lungs comparison mice without drug treatment. Consistently, showed pretreatment reduced activation GSK3β, decreased levels cytokines macrophages during infection. Conclusions: by inhibiting GSK3β/JNK/c-Jun signaling pathways activation, which effectively mitigated aeruginosa-induced inflammation injury, elevated rates

Language: Английский