Hyperhomocysteinaemia aggravates periodontitis by suppressing the Nrf2/HO-1 signalling pathway DOI Creative Commons
Kaiqiang Yang, Yuting Yang, Ting Long

et al.

Redox Report, Journal Year: 2025, Volume and Issue: 30(1)

Published: March 9, 2025

Periodontitis, a common dental illness, causes periodontal tissue inflammation and irreversible bone loss, inevitably resulting in tooth loss. Hyperhomocysteinaemia (HHcy), defined as blood total homocysteine (Hcy) levels greater than 15 µmol/L, is linked to increased cardiovascular disease risk. Mounting evidence indicates connection between HHcy periodontitis; however, the underlying processes remain unknown. Herein, we explored mechanisms by which exacerbates osteoclast formation. In an animal model of periodontitis treated with HHcy, attachment loss was aggravated, both systemic gingival tended increase; additionally, antioxidant-related proteins were suppressed expressed at low levels, whereas oxidative damage-related protein expression increased. RAW264.7 cells LPS or + Hcy, Hcy group presented reactive oxygen species (ROS) fluorescence intensity, Nrf2/HO-1 signalling pathway suppression associated inflammatory cytokine (TNF-α) expression. monocyte osteoclasts Rankl suppression, increase osteoclast-related (NFATc-1 CTSK), more pronounced osteoclastic phenotype. Therefore, may exacerbate severity generation promoting ROS production inhibiting pathway.

Language: Английский

Role of hyperhomocysteinemia in atherosclerosis: from bench to bedside DOI Creative Commons

Wende Tian,

Jianqing Ju,

Baoyi Guan

et al.

Annals of Medicine, Journal Year: 2025, Volume and Issue: 57(1)

Published: Feb. 3, 2025

Background Atherosclerosis is a leading cause of global mortality, driven by complex interactions between genetic, metabolic, and environmental factors. Among these, hyperhomocysteinemia (HHcy) has emerged as significant modifiable risk factor, contributing to endothelial dysfunction, oxidative stress, vascular inflammation. Despite increasing recognition its role in atherogenesis, the precise mechanisms clinical implications HHcy remain incompletely understood, necessitating comprehensive review connect recent mechanistic insights with practical applications.

Language: Английский

Citations

1
Hyperhomocysteinaemia aggravates periodontitis by suppressing the Nrf2/HO-1 signalling pathway DOI Creative Commons
Kaiqiang Yang, Yuting Yang, Ting Long

et al.

Redox Report, Journal Year: 2025, Volume and Issue: 30(1)

Published: March 9, 2025

Periodontitis, a common dental illness, causes periodontal tissue inflammation and irreversible bone loss, inevitably resulting in tooth loss. Hyperhomocysteinaemia (HHcy), defined as blood total homocysteine (Hcy) levels greater than 15 µmol/L, is linked to increased cardiovascular disease risk. Mounting evidence indicates connection between HHcy periodontitis; however, the underlying processes remain unknown. Herein, we explored mechanisms by which exacerbates osteoclast formation. In an animal model of periodontitis treated with HHcy, attachment loss was aggravated, both systemic gingival tended increase; additionally, antioxidant-related proteins were suppressed expressed at low levels, whereas oxidative damage-related protein expression increased. RAW264.7 cells LPS or + Hcy, Hcy group presented reactive oxygen species (ROS) fluorescence intensity, Nrf2/HO-1 signalling pathway suppression associated inflammatory cytokine (TNF-α) expression. monocyte osteoclasts Rankl suppression, increase osteoclast-related (NFATc-1 CTSK), more pronounced osteoclastic phenotype. Therefore, may exacerbate severity generation promoting ROS production inhibiting pathway.

Language: Английский

Citations

0