Elsevier eBooks, Journal Year: 2024, Volume and Issue: unknown, P. 439 - 466
Published: Nov. 8, 2024
Elsevier eBooks, Journal Year: 2024, Volume and Issue: unknown, P. 439 - 466
Published: Nov. 8, 2024
Inflammation, Journal Year: 2025, Volume and Issue: unknown
Published: March 8, 2025
Abstract Staphylococcal osteomyelitis is a serious infection of the bone and joints characterized by progressive inflammatory tissue damage leukocyte recruitment leading to net loss. Resident cells are capable recognizing Staphylococcus aureus initiating an immune response that recruits leukocytes alters homeostasis. Importantly, richly innervated with substance P containing nerve fibers we have previously shown this neuropeptide can augment responses both osteoblasts osteoclasts S. via neurokinin-1 receptors (NK-1R). Here, extended these studies demonstrating pharmacological inhibition NK-1R ameliorates disease severity in mouse model staphylococcal osteomyelitis. This effect was associated significant reduction leukocyte-attracting chemokine production following reduced local levels osteoclast neutrophil activity. We then assessed on bone-marrow derived gene expression absence or presence P. determined upregulates mRNAs encoding mediators include neutrophil-attracting chemokines identified vivo. found that, while has no mRNA infected cells, significantly increases release challenged but not osteoblasts. Together, data further support ability exacerbate indicate may be due, part, augmentation promote recruitment.
Language: Английский
Citations
0Life Sciences, Journal Year: 2024, Volume and Issue: unknown, P. 123210 - 123210
Published: Oct. 1, 2024
Language: Английский
Citations
1Elsevier eBooks, Journal Year: 2024, Volume and Issue: unknown, P. 439 - 466
Published: Nov. 8, 2024
Citations
0