Substance P Augments Chemokine Production by Staphylococcus aureus Infected Murine Osteoclasts

Inflammation, Journal Year: 2025, Volume and Issue: unknown

Published: March 8, 2025

Abstract Staphylococcal osteomyelitis is a serious infection of the bone and joints characterized by progressive inflammatory tissue damage leukocyte recruitment leading to net loss. Resident cells are capable recognizing Staphylococcus aureus initiating an immune response that recruits leukocytes alters homeostasis. Importantly, richly innervated with substance P containing nerve fibers we have previously shown this neuropeptide can augment responses both osteoblasts osteoclasts S. via neurokinin-1 receptors (NK-1R). Here, extended these studies demonstrating pharmacological inhibition NK-1R ameliorates disease severity in mouse model staphylococcal osteomyelitis. This effect was associated significant reduction leukocyte-attracting chemokine production following reduced local levels osteoclast neutrophil activity. We then assessed on bone-marrow derived gene expression absence or presence P. determined upregulates mRNAs encoding mediators include neutrophil-attracting chemokines identified vivo. found that, while has no mRNA infected cells, significantly increases release challenged but not osteoblasts. Together, data further support ability exacerbate indicate may be due, part, augmentation promote recruitment.

Language: Английский

---

Repurposing Aprepitant: Can it protect against doxorubicin-induced Chemobrain beyond its antiemetic role?

Life Sciences, Journal Year: 2024, Volume and Issue: unknown, P. 123210 - 123210

Published: Oct. 1, 2024

Language: Английский

---

Substance P in stroke

Elsevier eBooks, Journal Year: 2024, Volume and Issue: unknown, P. 439 - 466

Published: Nov. 8, 2024

---