Research progress of gene therapy combined with tissue engineering to promote bone regeneration DOI Creative Commons
Xiangyu Chu, Yuan Xiong, Li Lu

et al.

APL Bioengineering, Journal Year: 2024, Volume and Issue: 8(3)

Published: Sept. 1, 2024

Gene therapy has emerged as a highly promising strategy for the clinical treatment of large segmental bone defects and non-union fractures, which is common need. Meanwhile, many preclinical data have demonstrated that gene cell therapies combined with optimal scaffold biomaterials could be used to solve these tough issues. Bone tissue engineering, an interdisciplinary field combining cells, biomaterials, molecules stimulatory capability, provides alternatives enhance regeneration. To deliver localize growth factors associated intracellular signaling components into defect site, strategies bioengineering achieve uniform distribution sustained release ensure mesenchymal stem osteogenesis. In this review, we will describe process molecular changes during normal fracture healing, followed by advantages disadvantages various vectors engineering. The other bioactive peptides in regeneration particularly discussed. Finally, gene-activated illustrated through description characteristics synthetic methods.

Language: Английский

Research progress of gene therapy combined with tissue engineering to promote bone regeneration DOI Creative Commons
Xiangyu Chu, Yuan Xiong, Li Lu

et al.

APL Bioengineering, Journal Year: 2024, Volume and Issue: 8(3)

Published: Sept. 1, 2024

Gene therapy has emerged as a highly promising strategy for the clinical treatment of large segmental bone defects and non-union fractures, which is common need. Meanwhile, many preclinical data have demonstrated that gene cell therapies combined with optimal scaffold biomaterials could be used to solve these tough issues. Bone tissue engineering, an interdisciplinary field combining cells, biomaterials, molecules stimulatory capability, provides alternatives enhance regeneration. To deliver localize growth factors associated intracellular signaling components into defect site, strategies bioengineering achieve uniform distribution sustained release ensure mesenchymal stem osteogenesis. In this review, we will describe process molecular changes during normal fracture healing, followed by advantages disadvantages various vectors engineering. The other bioactive peptides in regeneration particularly discussed. Finally, gene-activated illustrated through description characteristics synthetic methods.

Language: Английский

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