Targeted Temperature Management for Out-of-Hospital Cardiac Arrest Survivors DOI Open Access

Noor Ul Huda Ramzan,

Rubaid Azhar Dhillon,

Mian Uman Anwer

et al.

Cureus, Journal Year: 2024, Volume and Issue: unknown

Published: Sept. 11, 2024

Targeted temperature management (TTM), specifically therapeutic hypothermia, has been proposed to provide neuroprotective and mortality benefits for out-of-hospital cardiac arrest (OHCA) survivors. This proposition was based on small-scale trials from the early 2000s, leading its incorporation into various international guidelines. The mechanisms include reducing cerebral metabolic rate, stabilizing blood-brain barrier, release of excitatory neurotransmitters, suppressing apoptotic pathways. However, these have criticized their high risk bias lack standardized protocols. Recent evidence more rigorously controlled randomized indicates no significant association between hypothermia improved neurological outcomes or survival rates. review explores latest clinical TTM OHCA patients, discussing pathophysiology, evaluating effectiveness through trials, providing recommendations future research practice.

Language: Английский

The Impact of Dispatcher-Assisted CPR and Prior Bystander CPR Training on Neurologic Outcomes in Out-of-Hospital Cardiac Arrest: A Multicenter Study DOI
Haruka Takahashi, Takashi Tagami,

Kensuke Suzuki

et al.

Resuscitation, Journal Year: 2025, Volume and Issue: unknown, P. 110617 - 110617

Published: April 1, 2025

Language: Английский

Citations

0
Effect of Cardiopulmonary Resuscitation Training for Layperson Bystanders on Outcomes of Out-of-Hospital Cardiac Arrest: A Prospective Multicenter Observational Study DOI

Ryusei Tabata,

Takashi Tagami,

Kensuke Suzuki

et al.

Resuscitation, Journal Year: 2024, Volume and Issue: 201, P. 110314 - 110314

Published: July 9, 2024

Language: Английский

Citations

1
Agonal breathing upon hospital arrival as a prognostic factor in patients experiencing out-of-hospital cardiac arrest DOI Creative Commons

Shinnosuke Kitano,

Kensuke Suzuki,

Chie Tanaka

et al.

Resuscitation Plus, Journal Year: 2024, Volume and Issue: 18, P. 100660 - 100660

Published: May 13, 2024

Agonal breathing is a relatively common symptom that follows cardiac arrest when the brainstem function preserved. associated with favorable survival in patients experiencing out-of-hospital (OHCA). While previous studies focused on agonal observed pre-hospital setting for all study subjects, we upon hospital arrival. In this multicenter prospective study, aimed to assess prognosis of exhibiting arrival were compared. We hypothesized at would be neurological outcomes among OHCA. The data incidence prospectively collected evaluable participants multicenter, observational Japan (SOS-KANTO [Survey Survivors after Out-of-Hospital Cardiac Arrest Kanto Area] 2017 Study). Groups and without compared Propensity-score inverse probability treatment weighting (IPTW) analysis was performed adjust confounding factors. primary outcome (Cerebral Performance Category 1–2) 1 month. A total 6,457 out 9,909 registered SOS-KANTO (in which 42 facilities participated) selected current study. There 128 (2.0%) with-agonal group 6,329 (98.0%) withoutagonal group. 1.1% 0.6% without-agonal (risk difference, 0.55; 95% confidence interval, 0.23–0.87) IPTW analysis. significantly better increased Thus, may useful prognostic predictor

Language: Английский

Citations

0
Targeted Temperature Management for Out-of-Hospital Cardiac Arrest Survivors DOI Open Access

Noor Ul Huda Ramzan,

Rubaid Azhar Dhillon,

Mian Uman Anwer

et al.

Cureus, Journal Year: 2024, Volume and Issue: unknown

Published: Sept. 11, 2024

Targeted temperature management (TTM), specifically therapeutic hypothermia, has been proposed to provide neuroprotective and mortality benefits for out-of-hospital cardiac arrest (OHCA) survivors. This proposition was based on small-scale trials from the early 2000s, leading its incorporation into various international guidelines. The mechanisms include reducing cerebral metabolic rate, stabilizing blood-brain barrier, release of excitatory neurotransmitters, suppressing apoptotic pathways. However, these have criticized their high risk bias lack standardized protocols. Recent evidence more rigorously controlled randomized indicates no significant association between hypothermia improved neurological outcomes or survival rates. review explores latest clinical TTM OHCA patients, discussing pathophysiology, evaluating effectiveness through trials, providing recommendations future research practice.

Language: Английский

Citations

0