Fixed-Dose Combination Use and Drug Adherence, Healthcare Utilization, and Costs DOI Creative Commons
Donglan Zhang, Jun Soo Lee, Nicole L. Therrien

et al.

medRxiv (Cold Spring Harbor Laboratory), Journal Year: 2024, Volume and Issue: unknown

Published: Nov. 29, 2024

BACKGROUND: Combination-pill therapy using fixed-dose combination (FDC) antihypertensives has the potential to improve hypertension control and management. However, combination-pill remains low. This study aims assess 1) association between subsequent medication adherence, healthcare utilization, costs 2) mitigate racial ethnic disparities in among Medicaid beneficiaries. METHODS: A retrospective cohort analysis was conducted 2017-2021 MerativeTM MarketScan® claims database. The sample included adults aged 18-64 years with hypertension, continuously enrolled one year before after a random index date of prescribed antihypertensives. compared multi-pill therapy. propensity-score overlap weighting method used balance characteristics individuals combination- Logistic models were for linear possession ratios (MPRs), negative binomial generalized costs. RESULTS: Compared therapy, associated improved adherence (3.17 MPR, 95% CI: 2.79 - 3.55), fewer hypertension-related emergency department visits (220 per 1,000 individuals, -235 – -204), hospitalizations (153 -160 -146), lower medical ($2,862 person, -$3,035 -$2,689). non-Hispanic White Black existed both FDC CONCLUSIONS: could management save program These findings may inform policies on antihypertensive coverage programs.

Language: Английский

What a World, What a World! DOI
Charles R. Doarn

Telemedicine Journal and e-Health, Journal Year: 2025, Volume and Issue: unknown

Published: April 17, 2025

Language: Английский

Citations

0
Fixed-Dose Combination Use and Drug Adherence, Healthcare Utilization, and Costs DOI Creative Commons
Donglan Zhang, Jun Soo Lee, Nicole L. Therrien

et al.

medRxiv (Cold Spring Harbor Laboratory), Journal Year: 2024, Volume and Issue: unknown

Published: Nov. 29, 2024

BACKGROUND: Combination-pill therapy using fixed-dose combination (FDC) antihypertensives has the potential to improve hypertension control and management. However, combination-pill remains low. This study aims assess 1) association between subsequent medication adherence, healthcare utilization, costs 2) mitigate racial ethnic disparities in among Medicaid beneficiaries. METHODS: A retrospective cohort analysis was conducted 2017-2021 MerativeTM MarketScan® claims database. The sample included adults aged 18-64 years with hypertension, continuously enrolled one year before after a random index date of prescribed antihypertensives. compared multi-pill therapy. propensity-score overlap weighting method used balance characteristics individuals combination- Logistic models were for linear possession ratios (MPRs), negative binomial generalized costs. RESULTS: Compared therapy, associated improved adherence (3.17 MPR, 95% CI: 2.79 - 3.55), fewer hypertension-related emergency department visits (220 per 1,000 individuals, -235 – -204), hospitalizations (153 -160 -146), lower medical ($2,862 person, -$3,035 -$2,689). non-Hispanic White Black existed both FDC CONCLUSIONS: could management save program These findings may inform policies on antihypertensive coverage programs.

Language: Английский

Citations

0