Trends in Protein Derived Materials for Wound Care Applications DOI
Muhammad Zubair,

Saadat Hussain,

Mujeeb-ur- Rehman

et al.

Biomaterials Science, Journal Year: 2024, Volume and Issue: unknown

Published: Nov. 1, 2024

Natural resource based polymers, especially those derived from proteins, have attracted significant attention for their potential utilization in advanced wound care applications. Protein materials provide superior biocompatibility, biodegradability, and other functionalities compared to conventional dressings. The effectiveness of various fabrication techniques, such as electrospinning, phase separation, self-assembly, ball milling, is examined the context developing protein-based healing. These methods produce a wide range forms, including hydrogels, scaffolds, sponges, films, bioinspired nanomaterials, each designed specific types wounds different stages This review presents comprehensive analysis recent research that investigates transformation proteins into healing Our focus on essential keratin, collagen, gelatin, silk, zein, albumin, we emphasize distinct traits roles management. Protein-based show promising biomedical engineering, offering improved capabilities reduced risks infection. It crucial explore use these clinical settings while also addressing challenges may arise commercialization future.

Language: Английский

Review on application of silk fibroin hydrogels in the management of wound healing DOI

Chang Kuk You,

C. Wang,

Zhenjiang Ma

et al.

International Journal of Biological Macromolecules, Journal Year: 2025, Volume and Issue: 298, P. 140082 - 140082

Published: Jan. 18, 2025

Language: Английский

Citations

3
Enzymatically Cross-Linked Hydrogel Beads Based on a Novel Poly(aspartamide) Derivative DOI Creative Commons

Wenzhuo Hou,

Hui Yi,

Guangyan Zhang

et al.

Gels, Journal Year: 2025, Volume and Issue: 11(2), P. 93 - 93

Published: Jan. 26, 2025

In recent years, hydrogel beads and in situ hydrogels have gained wide attention various fields such as biomedicine. this study, 3-(4-hydroxyphenyl) propionic acid (HP) was introduced into the side chain of poly(α,β-[N-(2-hydroxyethyl)-D,L-aspartamide]) (PHEA) to synthesize phenolic hydroxyl-functionalized poly(aspartamide) derivative PHEA-HP with enzyme-catalyzed cross-linking potential. First, chemical structure characterized by FT-IR, UV 1H NMR, results vitro cytotoxicity against L929 cell line hemolysis experiment showed that did not toxicity cells (viability > 90%) had good blood compatibility. Then, rheological measurement confirmed formation PHEA-HP-based a high storage modulus (G') around 104 Pa, vial-tilting method revealed gelation time aqueous solution could be tuned range 5-260 s varying concentrations hydrogen peroxide (H2O2) horseradish peroxidase (HRP). Finally, different diameters containing methylene blue (for easy observation) were prepared using coaxial needle syringe pumps, effect flow rate outer phase on also investigated. Therefore, may promising safe can used prepare for applications closely related human body.

Language: Английский

Citations

0
Hybrid hydrogel based on porcine-derived matrix with gallic acid and cerium-doped mesoporous bioactive glass for diabetic wound healing DOI Creative Commons

Haozeng,

Qinghong Lai,

Wanyou Liao

et al.

Materials & Design, Journal Year: 2025, Volume and Issue: unknown, P. 113714 - 113714

Published: Feb. 1, 2025

Language: Английский

Citations

0
Advanced healing potential of simple natural hydrogel loaded with sildenafil in combating infectious wounds DOI Creative Commons
Yifan Lai,

Wa Zhang,

Yizhang Chen

et al.

International Journal of Pharmaceutics X, Journal Year: 2025, Volume and Issue: unknown, P. 100328 - 100328

Published: March 1, 2025

Infected wounds are common clinical injuries that often complicated by inflammation and oxidative stress due to bacterial invasion. These typically suffer from impaired vascularization, which delays healing increases the risk of complications such as sepsis chronic wounds. Therefore, developing an effective treatment for infected is highly necessary. Egg white can promote cell regeneration repair, while chitosan in resisting Sildenafil believed have potential angiogenesis. Based on these properties, we prepared a new type hydrogel using egg framework, loaded with sildenafil (CEHS). The combines benefits its components, exhibiting good biocompatibility promoting proliferation migration NIH 3T3 (3T3) cells human umbilical vein endothelial (HUVEC), well angiogenesis HUVEC. It also exhibits significant antioxidant, anti-inflammatory, antibacterial properties against Escherichia coli (E. coli) Staphylococcus aureus (S. aureus). Additionally, mouse model wounds, CEHS effectively promoted wound through excellent antioxidant anti-inflammatory activity, pro-angiogenic effects. In summary, this simple-to-prepare, multifunctional natural shows great promise

Language: Английский

Citations

0
Role of Biomaterials in Promoting Wound Healing DOI
Saeedeh Zare Jalise, Mohsen Sheykhhasan

IGI Global eBooks, Journal Year: 2025, Volume and Issue: unknown, P. 367 - 412

Published: April 25, 2025

Because biomaterials can improve tissue repair and regeneration, their use in wound healing has drawn much attention. Biomaterials facilitate cellular connections, create favorable microenvironments, offer mechanical support, making them vital for promoting healing. These materials fall into three categories: natural, synthetic, hybrid. Natural polymers such as collagen, alginate, chitosan mimic the extracellular matrix biocompatibility, while synthetic like PLGA provide adjustable qualities strength degradation rates. Advanced hydrogels, nanoparticles, electrospun fibers enhance moisture retention, control drug release, reduce infection. They release bioactive chemicals growth factors antimicrobial peptides, preventing chronic wounds. This chapter examines various used healing, therapeutic uses, modes of action, well future developments challenges design, scalability.

Language: Английский

Citations

0
Trends in Protein Derived Materials for Wound Care Applications DOI
Muhammad Zubair,

Saadat Hussain,

Mujeeb-ur- Rehman

et al.

Biomaterials Science, Journal Year: 2024, Volume and Issue: unknown

Published: Nov. 1, 2024

Natural resource based polymers, especially those derived from proteins, have attracted significant attention for their potential utilization in advanced wound care applications. Protein materials provide superior biocompatibility, biodegradability, and other functionalities compared to conventional dressings. The effectiveness of various fabrication techniques, such as electrospinning, phase separation, self-assembly, ball milling, is examined the context developing protein-based healing. These methods produce a wide range forms, including hydrogels, scaffolds, sponges, films, bioinspired nanomaterials, each designed specific types wounds different stages This review presents comprehensive analysis recent research that investigates transformation proteins into healing Our focus on essential keratin, collagen, gelatin, silk, zein, albumin, we emphasize distinct traits roles management. Protein-based show promising biomedical engineering, offering improved capabilities reduced risks infection. It crucial explore use these clinical settings while also addressing challenges may arise commercialization future.

Language: Английский

Citations

2