Drosophila Toll-2 controls homeotic domain formation and timing of folding

bioRxiv (Cold Spring Harbor Laboratory), Journal Year: 2025, Volume and Issue: unknown

Published: Jan. 7, 2025

Abstract Tissue compartmentalization is a fundamental feature of animal development, crucial for determining cell fate, growth, and organ morphogenesis. Hox genes play essential conserved roles in specifying homeotic compartments along the antero-posterior axis body. Despite extensive characterization gene regulation, mechanisms underlying formation, maintenance, reshaping during development remain incompletely understood. Here, we investigate role Toll-2 receptor formation folding Deformed (Dfd) compartment, which produces neck adult Drosophila . We show that properly forming bilateral Dfd compartment through fusion two eye-antennal imaginal discs. Additionally, find regulates timing morphogenesis by promoting apoptosis cell-cell rearrangements preceding folding. Last, establish independently sequentially governs both its via PI3K Src signaling, respectively. Altogether, our findings provide novel insights into spatiotemporal regulation development.

Language: Английский

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Nuclear position controls the activity of cortical actomyosin networks powering simultaneous morphogenetic events

Nature Communications, Journal Year: 2025, Volume and Issue: 16(1)

Published: Feb. 12, 2025

Language: Английский

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EGFR-dependent actomyosin patterning coordinates morphogenetic movements between tissues in Drosophila melanogaster

Developmental Cell, Journal Year: 2024, Volume and Issue: unknown

Published: Oct. 1, 2024

Language: Английский

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Mechanical induction in metazoan development and evolution: from earliest multi-cellular organisms to modern animal embryos

Nature Communications, Journal Year: 2024, Volume and Issue: 15(1)

Published: Dec. 19, 2024

Language: Английский

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