Association of glymphatic system dysfunction with cognitive impairment in temporal lobe epilepsy DOI Creative Commons

Jiajia Wang,

Xiaona Xia, Bin Zhang

et al.

Frontiers in Aging Neuroscience, Journal Year: 2024, Volume and Issue: 16

Published: Oct. 18, 2024

Objectives To explore the relationship between glymphatic dysfunction and cognitive impairment in unilateral temporal lobe epilepsy (TLE). Methods This study retrospectively included 38 patients with TLE 26 age- gender-matched healthy controls (HCs). The diffusion tensor image analysis along perivascular space (DTI-ALPS) index, choroid plexus volume (CPV), assessment were obtained for each participant. Neuropsychological test batteries Montreal Cognitive Assessment (MoCA), Minimum Mental State Examination, Arithmetic Test (AT), Digit Symbol Substitution (DSST), Span (DST), Boston Naming Test, Block design, Phonological Fluency (PFT), Semantic Verbal (SVF). Results Compared to HCs, had lower scores of MoCA, AT, DSST, DST, PFT SVF (all p < 0.05) values mean DTI-ALPS index (1.491 ± 0.142 vs. 1.642 0.123, 0.001). Significantly observed ipsilateral hemisphere than contralateral (1.466 0.129 1.517 0.175, = 0.013) TLE. Correlation analyses found that performance was significantly or borderline associated function ( FDR-corrected 0.05 all 0.057 CPV) patients. Linear regression showed increased CPV decreased independent risk factors semantic fluency 0.05). Furthermore, mediation mediator role enlargement (indirect effect: β −0.182, 95%CI −0.486 −0.037). Conclusion These findings reveal important Decreased are impairment. may fully mediate CP performance. insights provide a radiological foundation further investigations into mechanism system pathophysiology.

Language: Английский

Diffusion Tensor Image Analysis ALong the Perivascular Space (DTI-ALPS): Revisiting the Meaning and Significance of the Method DOI Creative Commons
Toshiaki Taoka, Rintaro Ito, Rei Nakamichi

et al.

Magnetic Resonance in Medical Sciences, Journal Year: 2024, Volume and Issue: 23(3), P. 268 - 290

Published: Jan. 1, 2024

More than 5 years have passed since the Diffusion Tensor Image Analysis ALong Perivascular Space (DTI-ALPS) method was proposed with intention of evaluating glymphatic system. This is handy due to its noninvasiveness, provision a simple index in straightforward formula, and possibility retrospective analysis. Therefore, ALPS adopted evaluate system for many disorders studies. The purpose this review look back discuss at moment.

Language: Английский

Citations

64
Relationship of Perivascular Space Markers With Incident Dementia in Cerebral Small Vessel Disease DOI
Hui Hong, Daniel J. Tozer, Hugh S. Markus

et al.

Stroke, Journal Year: 2024, Volume and Issue: 55(4), P. 1032 - 1040

Published: March 11, 2024

BACKGROUND: Recent studies, using diffusion tensor image analysis along the perivascular space (DTI-ALPS), suggest impaired (PVS) function in cerebral small vessel disease, but they were cross-sectional, making inferences on causality difficult. We determined associations between PVS, measured DTI-ALPS and PVS volume, cognition incident dementia. METHODS: In patients with lacunar stroke confluent white matter hyperintensities, without dementia at baseline, recruited prospectively a single center, magnetic resonance imaging was performed annually for 3 years, cognitive assessments, including global, memory, executive function, processing speed, 5 years. volume disease markers (white hyperintensity lacunes, microbleeds) baseline changes markers. whether change over years predicted Analyses controlled conventional metrics 2 (median mean diffusivity [MD] peak width of skeletonized MD) adjusted age, sex, vascular risk factors. RESULTS: A total 120 patients, age 70.0 65.0% male, included. declined while no found. Neither nor associated marker progression. Baseline global (β=0.142, P =0.032), (β=0.287, =0.027), long-term memory (β=0.228, =0.027). Higher lower (hazard ratio, 0.328 [0.183–0.588]; <0.001), this remained significant after median MD as covariate 0.290 [0.139–0.602]; <0.001). Change conversion 0.630 [0.428–0.964]; =0.048), when entered covariates, association not significant. There or to CONCLUSIONS: predicts future strokes hyperintensities. However, weakening controlling suggests part signal may represent metrics. is predictor risk.

Language: Английский

Citations

15
Diffusion magnetic resonance imaging of cerebrospinal fluid dynamics: Current techniques and future advancements DOI
Adam M. Wright, Yu‐Chien Wu, Li Feng

et al.

NMR in Biomedicine, Journal Year: 2024, Volume and Issue: 37(9)

Published: May 7, 2024

Abstract Cerebrospinal fluid (CSF) plays a critical role in metabolic waste clearance from the brain, requiring its circulation throughout various brain pathways, including ventricular system, subarachnoid spaces, para‐arterial interstitial and para‐venous spaces. The complexity of CSF has posed challenge obtaining noninvasive measurements dynamics. assessment dynamics circulatory pathways is possible using diffusion magnetic resonance imaging (MRI) with optimized sensitivity to incoherent water movement across brain. This review presents an overview both established emerging MRI techniques designed measure their potential clinical applications. discussion offers insights into optimization acquisition parameters enhance specificity metrics on underlying Lastly, we emphasize importance cautious interpretations diffusion‐based imaging, especially when differentiating between tissue‐ fluid‐related changes or elucidating structural versus functional alterations.

Language: Английский

Citations

13
Glymphatic system dysfunction in epilepsy related to focal cortical dysplasia and its relationship with antiseizure medication response DOI
Bo Jin,

Jiahui Xu,

Jing Hu

et al.

Seizure, Journal Year: 2025, Volume and Issue: 125, P. 31 - 36

Published: Jan. 1, 2025

Language: Английский

Citations

1
Association between glymphatic system function and cognitive impairment in elderly patients with late-onset epilepsy DOI
Long Wang, Jie Hu, J. Li

et al.

Epilepsy & Behavior, Journal Year: 2025, Volume and Issue: 164, P. 110258 - 110258

Published: Jan. 18, 2025

Language: Английский

Citations

1
Effects of sleep on the glymphatic functioning and multimodal human brain network affecting memory in older adults DOI Creative Commons

Junji Ma,

Menglu Chen, Geng-Hao Liu

et al.

Molecular Psychiatry, Journal Year: 2024, Volume and Issue: unknown

Published: Oct. 14, 2024

Understanding how sleep affects the glymphatic system and human brain networks is crucial for elucidating neurophysiological mechanism underpinning aging-related memory declines. We analyzed a multimodal dataset collected through magnetic resonance imaging (MRI) polysomnographic recording from 72 older adults. A proxy of functioning was obtained Diffusion Tensor Image Analysis along Perivascular Space (DTI-ALPS) index. Structural functional were constructed based on MRI data, coupling between two (SC-FC coupling) also calculated. Correlation analyses revealed that DTI-ALPS negatively correlated with quality measures [e.g., Pittsburgh Sleep Quality Index (PSQI) apnea-hypopnea index]. Regarding networks, associated strength both connectivity (FC) structural (SC) involving regions such as middle temporal gyrus parahippocampal gyrus, well SC-FC rich-club connections. Furthermore, we found positively mediated association coupling. The further function in good sleepers but not poor sleepers. results suggest disrupted glymphatic-brain relationship sleepers, which underlies decline. Our findings add important evidence cognitive health underlying neural relationships interplay networks.

Language: Английский

Citations

8
Glymphatic function and its influencing factors in different glucose metabolism states DOI Open Access
Bin Tian, Chen Zhao, Jia-Li Liang

et al.

World Journal of Diabetes, Journal Year: 2024, Volume and Issue: 15(7), P. 1537 - 1550

Published: July 8, 2024

Dysfunction of the glymphatic system in brain different stages altered glucose metabolism and its influencing factors are not well characterized.

Language: Английский

Citations

7
Evaluating the glymphatic system via magnetic resonance diffusion tensor imaging along the perivascular spaces in brain tumor patients DOI Creative Commons

Gabriela Villacis,

Aileen Schmidt,

Justus Christian Rudolf

et al.

Japanese Journal of Radiology, Journal Year: 2024, Volume and Issue: 42(10), P. 1146 - 1156

Published: May 31, 2024

Abstract Purpose To investigate glymphatic system function in patients with brain tumors, including both primary and secondary using diffusion tensor imaging along perivascular spaces (DTI-ALPS). Methods We retrospectively analyzed the MR DTI of 24 unilateral tumors compared them age sex-matched controls. DTI-ALPS index ipsi- contralateral hemispheres. The region interest was placed periventricular vessels adjacent to lateral ventricles. Differences between sex, age, kind tumor (primary or metastasis) were evaluated. Correlations tumor's apparent coefficient (ADC) also investigated. Results significantly lower ( p < 0.05) tumor-affected hemisphere (mean = 1.26 ± 0.24) than 1.43 0.28). A comparison healthy controls revealed no significant difference on matched ipsilateral side. However, side larger HC. Additionally, statistically differences found when analyzing vs. entity. we did not find a correlation patient ADC. Conclusion decreased may be related impaired function. cancer is often systemic disease; thus, from generally considered as normal control. Nonetheless, does only reflect but it can influenced by factors such axonal degeneration. Therefore, directly waste clearance changes should interpreted carefully.

Language: Английский

Citations

6
Glymphatic System Dysfunction Underlying Schizophrenia Is Associated With Cognitive Impairment DOI
Ye Tu, Fang Yan, Guohui Li

et al.

Schizophrenia Bulletin, Journal Year: 2024, Volume and Issue: 50(5), P. 1223 - 1231

Published: April 6, 2024

Abstract Background and Hypothesis Despite the well-documented structural functional brain changes in schizophrenia, potential role of glymphatic dysfunction remains largely unexplored. This study investigates system’s function utilizing diffusion tensor imaging (DTI) to analyze water along perivascular space (ALPS), examines its correlation with clinical symptoms. Study Design A cohort consisting 43 people schizophrenia 108 healthy controls was examined. We quantified metrics x-, y-, z-axis both projection association fibers derive DTI-ALPS index, a proxy for activity. The differences ALPS index between groups were analyzed using 2-way ANCOVA controlling age sex, while partial correlations assessed variables. Results People showed significantly reduced across whole within hemispheres (F = 9.001, P .011; F 10.024, 5.927, .044; false discovery rate corrected), indicating schizophrenia. group by cognitive performance interaction effects on not observed. Moreover, lower associated poorer specific neuropsychological tests Conclusion Our highlights correlated more pronounced impairments. suggests that may contribute pathophysiology offering new insights into underlying mechanisms.

Language: Английский

Citations

5
Glymphatic Impairment Associated with Neurocognitive Dysfunction in Moyamoya Disease DOI
Chaofan Zeng,

Yuanren Zhai,

Peicong Ge

et al.

Translational Stroke Research, Journal Year: 2024, Volume and Issue: unknown

Published: April 17, 2024

Language: Английский

Citations

5