Association of glymphatic system dysfunction with cognitive impairment in temporal lobe epilepsy DOI Creative Commons

Jiajia Wang,

Xiaona Xia, Bin Zhang

et al.

Frontiers in Aging Neuroscience, Journal Year: 2024, Volume and Issue: 16

Published: Oct. 18, 2024

Objectives To explore the relationship between glymphatic dysfunction and cognitive impairment in unilateral temporal lobe epilepsy (TLE). Methods This study retrospectively included 38 patients with TLE 26 age- gender-matched healthy controls (HCs). The diffusion tensor image analysis along perivascular space (DTI-ALPS) index, choroid plexus volume (CPV), assessment were obtained for each participant. Neuropsychological test batteries Montreal Cognitive Assessment (MoCA), Minimum Mental State Examination, Arithmetic Test (AT), Digit Symbol Substitution (DSST), Span (DST), Boston Naming Test, Block design, Phonological Fluency (PFT), Semantic Verbal (SVF). Results Compared to HCs, had lower scores of MoCA, AT, DSST, DST, PFT SVF (all p < 0.05) values mean DTI-ALPS index (1.491 ± 0.142 vs. 1.642 0.123, 0.001). Significantly observed ipsilateral hemisphere than contralateral (1.466 0.129 1.517 0.175, = 0.013) TLE. Correlation analyses found that performance was significantly or borderline associated function ( FDR-corrected 0.05 all 0.057 CPV) patients. Linear regression showed increased CPV decreased independent risk factors semantic fluency 0.05). Furthermore, mediation mediator role enlargement (indirect effect: β −0.182, 95%CI −0.486 −0.037). Conclusion These findings reveal important Decreased are impairment. may fully mediate CP performance. insights provide a radiological foundation further investigations into mechanism system pathophysiology.

Language: Английский

Aging and physiological barriers: mechanisms of barrier integrity changes and implications for age-related diseases DOI
Ilya Solovev,

Alena D. Sergeeva,

Anastasya Geraskina

et al.

Molecular Biology Reports, Journal Year: 2024, Volume and Issue: 51(1)

Published: Aug. 19, 2024

Language: Английский

Citations

4
Different Imaging Evaluating Performances Between Glymphatic System and Motor Symptoms and Levodopa Responsiveness of Parkinson Disease DOI

Jin-Huan Deng,

Hanwen Zhang,

Xinxin Lan

et al.

Journal of Computer Assisted Tomography, Journal Year: 2025, Volume and Issue: unknown

Published: Jan. 27, 2025

Background and Purpose: Parkinson disease (PD) is defined by its unique motor symptoms, where responsiveness to levodopa (L-DOPA) fundamental for management. Recent research has highlighted a significant relationship between PD symptoms glymphatic dysfunction. This study endeavors clarify the connection system functionality initial in PD, utilizing imaging biomarkers determine predictive capacity L-DOPA (LR). Materials Methods: Retrospective of 86 patients with 3.0-T MRI scans (July 2019 March 2021), assessing diffusion tensor image analysis along perivascular space (DTI-ALPS) methods, enlarged spaces (ePVSs) load, choroid plexus volume (CPV). Analyzed metrics versus third part Unified Disease Rating Scale (UPDRSIII) scores %LR using linear regression, creating prediction model challenge. Explored relationships age, sex, Hoehn Yahr stage, Montreal Cognitive Assessment scores, Mini-Mental State Examination score. Examined DTI-ALPS index, ePVSs, CPV interrelations. Results: Pre-L-DOPA, UPDRSIII inversely correlated index ( P =0.049), positively bilateral basal ganglia ePVSs <0.001). Age-adjusted BG-ePVSs-UPDRSIII link Post-L-DOPA, similarly was positive. linked <0.001), negatively BG-ePVSs =0.04), Adjusted %LR-DTI-ALPS positive =0.005), %LR-CPV negative =0.04). predicted LCT outcomes (%LR ≥33%) area under curves 0.78, 0.79; accuracies 86.01%, 81.4%. The combined curve 0.82, an accuracy 87.2%. Significant correlations were observed (CPV-DTI-ALPS, CPV-ePVSs, DTI-ALPS-ePVSs). Conclusions: A affirms impairment, responses PD. As function declines, worsen, effectiveness diminishes. emerge as potential predictors patient outcomes.

Language: Английский

Citations

0
Cortical Morphology Alterations Mediate the Relationship Between Glymphatic System Function and the Severity of Asthenopia DOI Creative Commons
Yilei Chen,

Jun Xu,

Yingnan Kong

et al.

International Journal of Biomedical Imaging, Journal Year: 2025, Volume and Issue: 2025(1)

Published: Jan. 1, 2025

Objectives: This study is aimed at assessing glymphatic function by diffusion tensor image analysis along the perivascular space (DTI-ALPS) and its associations with cortical morphological changes severity of accommodative asthenopia (AA). Methods: We prospectively enrolled 50 patients AA 47 healthy controls (HCs). All participants underwent imaging (DTI) T1-weighted completed survey scale (ASS). Differences in brain morphometry (ALPS) index between two groups were compared. The correlation mediation analyses conducted to explore relationships them. Results: Compared HCs, exhibited significantly increased sulcal depth left superior occipital gyrus (SOG.L) thickness temporal (STG.L), middle (MOG.L), postcentral (PoCG.L), precuneus (PCUN.L). Additionally, had a lower ALPS than HCs. SOG.L was positively correlated ASS score AA, positive found MOG.L score. negatively associated MOG.L. Mediation revealed that partially mediated impact DTI-ALPS on Conclusion: Our findings suggested exhibit impaired function, which may contribute through influence changes. anticipated become potential biomarker for AA. Trial Registration: Chinese Registry Clinical Trials: ChiCTR1900028306.

Language: Английский

Citations

0
Genome-wide association study unravels mechanisms of brain glymphatic activity DOI Creative Commons

Shu‐Yi Huang,

Yi‐Jun Ge,

Peng Ren

et al.

Nature Communications, Journal Year: 2025, Volume and Issue: 16(1)

Published: Jan. 13, 2025

Language: Английский

Citations

0
Coupling analysis of diffusion tensor imaging analysis along the perivascular space (DTI-ALPS) with abnormal cerebral blood flow in methamphetamine-dependent patients and its application in machine-learning-based classification DOI

Ping Cheng,

Yadi Li, Shuyuan Wang

et al.

Journal of Affective Disorders, Journal Year: 2025, Volume and Issue: unknown

Published: Feb. 1, 2025

Language: Английский

Citations

0
Increased glymphatic system activity and thalamic vulnerability in drug-naive somatic depression: Evidenced by DTI-ALPS index DOI Creative Commons
Zipeng Deng, Wei Wang,

Zhaowen Nie

et al.

NeuroImage Clinical, Journal Year: 2025, Volume and Issue: unknown, P. 103769 - 103769

Published: March 1, 2025

Language: Английский

Citations

0
Glymphatic function decline as a mediator of core memory-related brain structures atrophy in aging DOI

Shan Chong,

Sanwang Wang, Teng Gao

et al.

Journal of Translational Internal Medicine, Journal Year: 2025, Volume and Issue: 13(1), P. 65 - 77

Published: Feb. 1, 2025

This study aimed to elucidate the role of glymphatic system-a crucial pathway for clearing waste in brain-in aging process and its contribution cognitive decline. We specifically focused on diffusion tensor imaging analysis along perivascular space (ALPS) index as a noninvasive biomarker function. Data were drawn from Alzheimers Disease Neuroimaging Initiative (ADNI) database separate validation cohort analyze ALPS cognitively normal older adults. The relationships among index, brain morphometry, memory performance examined. As function, appeared decline with age both cohorts. According morphology analysis, was positively correlated thickness left entorhinal cortex (r = 0.258, P false discovery rate (FDR) 2.96 × 10-4), it played mediating between thinning. independent further validated correlation 0.414, FDR 0.042). Additionally, primary cohorts, significant relationship durable or delayed highlights promising function links atrophy core regions during aging. Furthermore, these results suggest that targeting dysfunction could represent novel therapeutic approach mitigate age-related

Language: Английский

Citations

0
Brain physiological pulsations are linked to sleep architecture and cognitive performance in older adults DOI Creative Commons

Rodolphe Nenert,

Christina Mueller,

Corina Catiul

et al.

NeuroImage, Journal Year: 2025, Volume and Issue: unknown, P. 121187 - 121187

Published: April 1, 2025

The glymphatic system facilitates efficient waste clearance in the brain through movement of cerebrospinal fluid (CSF) along perivascular spaces. Animal studies have demonstrated that efficiency declines with age, but evidence for such decline humans is limited. We hypothesized reduced older adults may be related to age-related worsening sleep quality, potentially contributing cognitive impairment. 20 participants aged ≥60 years provided multi-dimensional measures, overnight polysomnography, and Magnetic Resonance Encephalography (MREG) performed morning following PSG. MREG a single-shot, three-dimensional (3D) sequence employing spherical stack-of-spirals trajectory undersamples 3D k-space, enabling whole-brain data acquisition every 100 milliseconds non-invasively dynamically assess physiological pulsations. Spectral power optical flow analyses quantified pulsations within cardiovascular (CvB; 0.52-1.6Hz), respiratory (RFB; 0.11-0.44Hz), low-frequency (LFB; 0.008-0.1Hz) bands. These measures were correlated test scores parameters assessed by polysomnography. Significant associations emerged between pulsations, sleep, measures. Cardiovascular pulsation strength non-rapid eye (NREM) stage 3 (N3) percentage (peak voxel right frontal pole; r=0.72, p<0.001) language domain performance (left calcarine gyrus; r=0.56, p=0.01). Respiratory strongly onset latency (right inferior temporal r=0.75, p<0.001). Additionally, associated precentral r=0.67, p=0.002). findings suggest efficiency, as reflected closely linked quality adults, particularly involving cortical subcortical structures relevant regulatory functions. This study uniquely demonstrates measured are significantly architecture adults. underscore potential function provide important insights into mechanisms linking disturbances, decline, aging. identified correlations specific regions highlight pathways which impaired could contribute suggesting promising avenues future clinical research applications.

Language: Английский

Citations

0
Poor glymphatic function is associated with mild cognitive impairment and its progression to Alzheimer's disease: A DTI-ALPS study DOI Creative Commons
Cuiping Bao, Hongbin Luo, Jiao Wang

et al.

The Journal of Prevention of Alzheimer s Disease, Journal Year: 2025, Volume and Issue: unknown, P. 100156 - 100156

Published: April 1, 2025

We aimed to explore the association between ALPS index and both risks of MCI from cognitively normal (CN) incident AD progressed MCI, as well potential mediating factors. This study included 519 adults including 253 (48.75 %) CN 266 (51.25 participants Alzheimer's Disease Neuroimaging Initiative. Glymphatic function (assessed by along perivascular space [ALPS] index) was measured diffusion tensor image at baseline. Neurobiomarkers (Aβ tau CSF, plasma PET) cognitive functions were served mediators. Data analyzed using Cox Laplace regression mediation analysis. During follow-up (median 3.6 years, interquartile range [IQR]: 2.0-4.9 years), 30 (11.86 developed in cohort 73 (27.4 cohort. The hazard ratios (95 % confidence intervals [CIs]) higher 0.605 (0.386-0.948) for 0.501 (0.356-0.706) AD. In addition, with high had 3.837 3.466 years prolonged onset AD, separately. Aβ choroid plexus (17.1 %), cortex [Inferiortemporal (21.1 Middletemporal (AV1451:17.0 %, FTP:15.5 Superiortemporal(7.7 Meta_temporal (AV1451:17.5 FTP:16.6 %)], executive (14.1 mediated MCI-AD progression. High decreases risk delays progression approximately 3.5 years. plexus, cortex, may partially mediate relation index.

Language: Английский

Citations

0
Glymphatic function and choroid plexus volume is associated with systemic inflammation and oxidative stress in major depressive disorder DOI

Wenyue Gong,

Qinghua Zhai, Yiwen Wang

et al.

Brain Behavior and Immunity, Journal Year: 2025, Volume and Issue: 128, P. 266 - 275

Published: April 11, 2025

Language: Английский

Citations

0