Journal of Cardio-diabetes and metabolic disorders,
Journal Year:
2023,
Volume and Issue:
3(2), P. 21 - 29
Published: July 1, 2023
Abstract
Diabetes
mellitus
is
one
of
the
most
prevalent
chronic
diseases
that
affect
a
significant
portion
“Golden-agers”
worldwide.
With
globally
rising
elderly
population
and
increasing
life
expectancy,
prevalence
diabetes
among
older
adults
expected
to
rise,
leading
morbidity
mortality
them
along
with
substantial
healthcare
burden.
The
type
2
(T2DM)
increases
age
extent
almost
half
diagnosed
diabetic
patients
are
now
above
65
years
age.
In
India,
overall
was
found
be
between
12%
20%
which
significantly
higher
in
urban
areas
than
rural.
etiology
T2DM
highly
diverse
but
mostly
associated
various
degrees
essential
insulin
resistance,
dysfunction
pancreatic
β-cell,
surplus
fat
accumulation,
loss
muscle
mass.
geriatric
population,
outline
management
has
moved
from
predominantly
glucose-lowering
approach
focused
complications-centric
approach,
aimed
at
preventing
mainly
short-term
long-term
complications
diabetes,
correcting
metabolic
abnormalities
managing
other
comorbidities
may
complicate
diabetes.
poses
unique
challenges
due
complex
interplay
aging,
comorbidities,
polypharmacy,
altered
physiological
responses
glucose
metabolism
necessitate
individualized
approaches.
Also,
presence
cognitive
decline,
frailty,
functional
impairment,
lack
familial
social
support,
varied
psychological
issues
further
raised
plasma
glucose.
This
review
aims
provide
an
in-depth
understanding
comprehensive
elderly,
focusing
on
critical
aspects
such
as
diagnosis,
treatment
strategies,
monitoring,
complications.
Diabetes & Metabolism Journal,
Journal Year:
2024,
Volume and Issue:
48(5), P. 837 - 846
Published: Sept. 13, 2024
People
with
type
2
diabetes
mellitus
(T2DM)
are
at
higher
risk
of
developing
cardiovascular
disease,
heart
failure,
chronic
kidney
and
premature
death
than
people
without
diabetes.
Therefore,
treatment
aims
to
reduce
these
complications.
Sodium-glucose
co-transporter
(SGLT2)
inhibitors
have
shown
beneficial
effects
on
cardiorenal
metabolic
health
beyond
glucose
control,
making
them
a
promising
class
drugs
for
achieving
the
ultimate
goals
treatment.
However,
despite
their
proven
benefits,
use
SGLT2
in
eligible
patients
T2DM
remains
suboptimal
due
reports
adverse
events.
The
is
particularly
limited
older
because
lack
experience
insufficient
long-term
safety
data.
This
article
comprehensively
reviews
risk-benefit
profile
T2DM,
drawing
data
from
prospective
randomized
controlled
trials
outcomes,
original
studies,
subgroup
analyses
across
different
age
groups,
observational
cohort
studies.
Vnitřní lékařství,
Journal Year:
2024,
Volume and Issue:
70(7), P. 430 - 437
Published: Nov. 14, 2024
Naděje
dožití
se
u
pacientů
s
diabetem
prodlužuje.
Prevalence
diabetu
zvyšuje
věkem.
Nové
třídy
antidiabetik
(glifloziny,
inkretinová
terapie,
nová
analoga
inzulinu)
jsou
bezpečnější,
mají
minimálně
srovnatelnou
účinnost
běžnou
léčbou,
přinášejí
navíc
i
pozitivní
ovlivnění
rizika
manifestace
pozdních
komplikací
diabetu.
Využití
jejich
potenciálu
pro
léčbu
seniorů
je
přinosné
zejména
z
hlediska
bezpečnosti
a
prevence
komplikací.
Journal of Cardio-diabetes and metabolic disorders,
Journal Year:
2023,
Volume and Issue:
3(2), P. 21 - 29
Published: July 1, 2023
Abstract
Diabetes
mellitus
is
one
of
the
most
prevalent
chronic
diseases
that
affect
a
significant
portion
“Golden-agers”
worldwide.
With
globally
rising
elderly
population
and
increasing
life
expectancy,
prevalence
diabetes
among
older
adults
expected
to
rise,
leading
morbidity
mortality
them
along
with
substantial
healthcare
burden.
The
type
2
(T2DM)
increases
age
extent
almost
half
diagnosed
diabetic
patients
are
now
above
65
years
age.
In
India,
overall
was
found
be
between
12%
20%
which
significantly
higher
in
urban
areas
than
rural.
etiology
T2DM
highly
diverse
but
mostly
associated
various
degrees
essential
insulin
resistance,
dysfunction
pancreatic
β-cell,
surplus
fat
accumulation,
loss
muscle
mass.
geriatric
population,
outline
management
has
moved
from
predominantly
glucose-lowering
approach
focused
complications-centric
approach,
aimed
at
preventing
mainly
short-term
long-term
complications
diabetes,
correcting
metabolic
abnormalities
managing
other
comorbidities
may
complicate
diabetes.
poses
unique
challenges
due
complex
interplay
aging,
comorbidities,
polypharmacy,
altered
physiological
responses
glucose
metabolism
necessitate
individualized
approaches.
Also,
presence
cognitive
decline,
frailty,
functional
impairment,
lack
familial
social
support,
varied
psychological
issues
further
raised
plasma
glucose.
This
review
aims
provide
an
in-depth
understanding
comprehensive
elderly,
focusing
on
critical
aspects
such
as
diagnosis,
treatment
strategies,
monitoring,
complications.
