Executive Functions are Independently Associated with Cognitive Dispersion in HIV Disease DOI
Romeo Penheiro, Troy A. Webber, Andrew M. Kiselica

et al.

Archives of Clinical Neuropsychology, Journal Year: 2024, Volume and Issue: unknown

Published: Sept. 17, 2024

Abstract Objective People with HIV (PWH) can demonstrate elevated cognitive intraindividual variability (IIV-dispersion) that is associated everyday functioning problems. Higher IIV-dispersion theorized to reflect lapses in executive aspects of control, but few studies have directly evaluated this possibility. Method 72 PWH completed the Cogstate and clinical measures functions, psychomotor speed, episodic memory. was calculated coefficient variation (CoV) from six age-adjusted subtest scores. Results Multiple regression showed three domain-level predictors explained 8% variance CoV (p = .03). Within model, poorer functions were moderately higher .01), memory domains not (ps > .05). Conclusions Findings align theory demonstrating uniquely independent among PWH. Future experimental mechanistic are needed determine precise IIV-dispersion.

Language: Английский

Social Determinants of Health and Cross-Sectional Cognitive Intra-Individual Variability in Adults from the Deep South Living with HIV DOI
Victor A. Del Bene, Pariya L. Fazeli, Jason Blake

et al.

Archives of Clinical Neuropsychology, Journal Year: 2025, Volume and Issue: unknown

Published: Jan. 8, 2025

Abstract Cognitive intra-individual variability (IIV) is a sensitive marker of neuropathology and increased in people with HIV (PWH). In sample PWH from the United States Deep South, we examined relationship cognitive IIV impairment social determinants health (SDoH). This secondary analysis included 131 larger training protocol. Our primary outcome measure was coefficient variation (CoV). We also individual standard deviation (iSD), both calculated demographically adjusted T-scores unadjusted sample–based scores. Mixed-effects models investigated between severity (i.e., Global Rating Score), SDoH, clinical variables. Bivariate correlations were used to further explore these relationships. Greater associated greater PWH, when accounting for demographic factors. When sample, then no longer impairment, but race (>IIV Black African American participants). Demographically global cognition, Wide Range Achievement Test–Fourth Edition reading score, viral load (iSD only). No significant using metrics. seen those participants, lower Further research on psychometric properties other populations needed, as results varied depending normative adjustments.

Language: Английский

Citations

0
Application of the Uniform Data Set version 3 tele-adapted test battery (T-cog) for remote cognitive assessment preoperatively in older adults DOI Creative Commons
Mika M. Rockholt,

Rachel R. Wu,

Elaine Zhu

et al.

Frontiers in Aging Neuroscience, Journal Year: 2025, Volume and Issue: 16

Published: Jan. 17, 2025

Introduction Older adults undergoing surgery are at risk of postoperative neurocognitive disorders, prompting the need for preoperative cognitive screening in this population. Traditionally, has been conducted in-person using brief assessment tools such as Montreal Cognitive Assessment (MoCA) or Mini-Mental State Examination (MMSE). More comprehensive test batteries, Uniform Data Set (UDS) Neuropsychological Battery, and its remote testing version, version 3 tele-adapted battery (UDS v3.0 T-cog), have developed to assess decline normal aging disease conditions, but not applied perioperative setting. Methods We assessed feasibility UDS T-cog 81 older 65+ scheduled lower extremity joint replacement surgery. Results Our results indicate that achieves 99% completion rates demonstrates high patient satisfaction. Further, we found 28% subjects were cognitively impaired cohort. Discussion These findings suggest is a feasible tool assessing function adult To our knowledge, first study apply

Language: Английский

Citations

0
Dispersion-based cognitive intra-individual variability in former American football players: Association with traumatic encephalopathy syndrome, repetitive head impacts, and biomarkers DOI
Caroline Altaras, Monica T. Ly,

Olivia Schultz

et al.

The Clinical Neuropsychologist, Journal Year: 2025, Volume and Issue: unknown, P. 1 - 29

Published: Jan. 26, 2025

Background: Exposure to repetitive head impacts (RHI), such as those experienced in American football, is linked cognitive dysfunction later life. Traumatic encephalopathy syndrome (TES) a proposed clinical thought be neuropath-ology of chronic traumatic (CTE), condition associated with RHI from football. Cognitive intra-individual variability (d-CIIV) measures test-score dispersion, indicating dysfunction. This study examined d-CIIV former football players and its associations TES diagnosis, exposure, DTI CSF biomarkers. Methods: Data included 237 males (45-74 years) DIAGNOSE CTE Research Project, including professional college (COL) (n = 173) asymptomatic men without or TBI 55). Participants completed neuropsychological tests. diagnosis was based on 2021 NINDS criteria. Years play cumulative impact index (CHII) measured exposure. Lumipulse technology used for assays. fractional anisotropy assessed white matter integrity. Coefficient variation (CoV) d-CIIV. ANCOVA compared among groups (football versus control; TES-status). Pearson correlations linear regressions tested between d-CIIV, Results: Former had higher than controls (F(7, 194) 2.87, p .007). (F(8, 146) 9.063, < .001), highest Possible/Probable-CTE. Higher correlated CHII scores (r 0.19), reduced Aβ1-42 (β -0.302), increased p-tau181 0.374), FA -0.202). Conclusion: exposure players, changes biomarkers

Language: Английский

Citations

0
Cognitive Intra-individual Variability in Cognitively Healthy APOE ε4 Carriers, Mild Cognitive Impairment, and Alzheimer’s Disease: a Meta-analysis DOI
Stephen L. Aita, Victor A. Del Bene,

D. Knapp

et al.

Neuropsychology Review, Journal Year: 2024, Volume and Issue: unknown

Published: Nov. 21, 2024

Language: Английский

Citations

1
Examining the Stability and Predictive Utility of Across- and Within-Domain Intra-Individual Variability in Mild Cognitive Impairment DOI
Libby A. DesRuisseaux, Jasmin E. Guevara, Kevin Duff

et al.

Archives of Clinical Neuropsychology, Journal Year: 2024, Volume and Issue: unknown

Published: July 13, 2024

Abstract Objective Dispersion is a form of intra-individual variability across neuropsychological tests that has been shown to predict cognitive decline. However, few studies have investigated the stability and predictive utility both across- within-domain dispersion. The current study aims fill these gaps in literature by examining multiple indices dispersion longitudinal clinical sample individuals diagnosed with mild impairment (MCI) at baseline. Method Two hundred thirty-eight MCI patients from disorders clinic underwent testing baseline after approximately 1.5 years. Linear regression was used examine whether predicted decline whose diagnostic classification progressed dementia (i.e., MCI-Decline) those who retained an diagnosis follow-up MCI-Stable). Cognitive operationalized dichotomously using group status continuously standardized regression-based (SRB) z-scores. Results variables were positively correlated groups, exception executive functioning language MCI-Decline group. None conversion MCI. Using SRB z-scores, greater across-domain overall follow-up, but this not case for visuospatial skills. Conclusions suggest are relatively stable time, subtle results also highlight findings may differ based on included calculations.

Language: Английский

Citations

0
Does neuropsychological intraindividual variability index cognitive dysfunction, an invalid presentation, or both? Preliminary findings from a mixed clinical older adult veteran sample DOI
Troy A. Webber, Sara A. Lorkiewicz, Steven Paul Woods

et al.

Journal of Clinical and Experimental Neuropsychology, Journal Year: 2024, Volume and Issue: 46(6), P. 535 - 556

Published: July 2, 2024

Intraindividual variability across a battery of neuropsychological tests (IIV-dispersion) can reflect normal variation in scores or arise from cognitive impairment. An alternate interpretation is IIV-dispersion reflects reduced engagement/invalid test data, although extant research addressing this significantly limited.

Language: Английский

Citations

0
Cognitive dispersion and its functional relevance in behavioral variant frontotemporal dementia and prodromal behavioral variant frontotemporal dementia. DOI
Troy A. Webber, Steven Paul Woods, Sara A. Lorkiewicz

et al.

Neuropsychology, Journal Year: 2024, Volume and Issue: 38(7), P. 637 - 652

Published: Aug. 29, 2024

Executive dysfunction is characteristic of behavioral variant frontotemporal dementia (bvFTD) but can be challenging to detect. Dispersion-based intraindividual variability (IIV-d) hypothesized reflect a sensitive index executive and has demonstrated relevance functional decline not been evaluated in bvFTD.

Language: Английский

Citations

0
Executive Functions are Independently Associated with Cognitive Dispersion in HIV Disease DOI
Romeo Penheiro, Troy A. Webber, Andrew M. Kiselica

et al.

Archives of Clinical Neuropsychology, Journal Year: 2024, Volume and Issue: unknown

Published: Sept. 17, 2024

Abstract Objective People with HIV (PWH) can demonstrate elevated cognitive intraindividual variability (IIV-dispersion) that is associated everyday functioning problems. Higher IIV-dispersion theorized to reflect lapses in executive aspects of control, but few studies have directly evaluated this possibility. Method 72 PWH completed the Cogstate and clinical measures functions, psychomotor speed, episodic memory. was calculated coefficient variation (CoV) from six age-adjusted subtest scores. Results Multiple regression showed three domain-level predictors explained 8% variance CoV (p = .03). Within model, poorer functions were moderately higher .01), memory domains not (ps &gt; .05). Conclusions Findings align theory demonstrating uniquely independent among PWH. Future experimental mechanistic are needed determine precise IIV-dispersion.

Language: Английский

Citations

0