Emerging trends in functional genomics in Spiralia DOI
José M. Martín‐Durán

Briefings in Functional Genomics, Journal Year: 2023, Volume and Issue: 22(6), P. 485 - 486

Published: Nov. 1, 2023

Journal Article Emerging trends in functional genomics Spiralia Get access José M Martín-Durán Corresponding author: M. Martín-Durán, Queen Mary University of London, School Biological and Behavioural Sciences. E-mail: [email protected] https://orcid.org/0000-0002-2572-1061 Search for other works by this author on: Oxford Academic PubMed Google Scholar Briefings Functional Genomics, Volume 22, Issue 6, November 2023, Pages 485–486, https://doi.org/10.1093/bfgp/elad048 Published: 17 2023 history Received: 20 October Accepted: 23

Language: Английский

The application of irreversible genomic states to define and trace ancient cell type homologies DOI Creative Commons
Oleg Simakov, Günter P. Wagner

EvoDevo, Journal Year: 2025, Volume and Issue: 16(1)

Published: May 3, 2025

Homology, or relationship among characters by common descent, has been notoriously difficult to assess for many morphological features, and cell types in particular. The ontogenetic origin of traits means that the only physically inherited information is encoded genomes. However, complexity underlying gene regulatory network often miniscule changes can impact expression, make it practically impossible postulate a clear demarcation line what molecular signature should "define" homologous type between two deeply branching animals. In this Hypothesis article, we propose use recently characterized irreversible genomic states, occur after chromosomal sub-chromosomal mixing genes elements, dissect signatures each into reversible configurations. While such states will be non-functional, some may permanently expression given type. Our proposal evolutionarily irreversible, thus synapomorphic, functional constitute criterion timing deep evolutionary homologies. aims close gap clearly defined homology individual their at phenotypic level through identification linked states.

Language: Английский

Citations

0

Topological mixing and irreversibility in animal chromosome evolution DOI Creative Commons
Darrin T. Schultz, Arno Blümel, Dalila Destanović

et al.

bioRxiv (Cold Spring Harbor Laboratory), Journal Year: 2024, Volume and Issue: unknown

Published: July 30, 2024

Abstract/Summary Paragraph Animal chromosomes can persist with recognizable homology over hundreds of millions years, in spite homology-obfuscating processes such as chromosomal fusion and translocation. The frequency pace these major genome structural changes are unknown, it remains unclear whether or how they impact long-term evolution. Here, we compare whole sequences 3,631 genomes from 2,291 species spanning all animal clades show that karyotypes evolve primarily via karyotype contraction, associated increased rates fusion-with-mixing dispersion largely obey algebra 1 , expansion, which breaks up ancestral linkage groups forms new elements non-algebraic changes. We be extinction events. Using a multi-scale encoding pan-animal manifold representation genomic changes, find evolution is not only driven by at the level, but subchromosomal mixing irreversibility define clade-specific this ‘evolutionary topology’ approach, calculate extrema irreversible configurations identify occupy intermediate positions, providing evidence for distinct macro-evolutionary trajectories. propose investigation mixed state accumulation around important gene loci (such Hox) will crucial capturing further study regulatory innovations.

Language: Английский

Citations

3

Emerging trends in functional genomics in Spiralia DOI
José M. Martín‐Durán

Briefings in Functional Genomics, Journal Year: 2023, Volume and Issue: 22(6), P. 485 - 486

Published: Nov. 1, 2023

Journal Article Emerging trends in functional genomics Spiralia Get access José M Martín-Durán Corresponding author: M. Martín-Durán, Queen Mary University of London, School Biological and Behavioural Sciences. E-mail: [email protected] https://orcid.org/0000-0002-2572-1061 Search for other works by this author on: Oxford Academic PubMed Google Scholar Briefings Functional Genomics, Volume 22, Issue 6, November 2023, Pages 485–486, https://doi.org/10.1093/bfgp/elad048 Published: 17 2023 history Received: 20 October Accepted: 23

Language: Английский

Citations

0