Research progress of ferroptosis pathway and its related molecular ubiquitination modification in liver cancer

Frontiers in Oncology, Journal Year: 2025, Volume and Issue: 15

Published: March 21, 2025

As a new type of programmed cell death, ferroptosis is characterized by iron metabolism disorder and reactive oxygen species (ROS) accumulation, involved in regulating the occurrence development cancer cells. Especially field liver treatment, shows great potential because it can induce tumor death. Ubiquitination process protein post-translational modification, which affect stability proteins regulate progress ferroptosis. This article reviews research ubiquitination modification molecules related to pathway regulation cancer, providing strategy for treatment cancer.

Language: Английский

FerroEnrich: An Interactive web tool for computing Ferroptosis index and gene enrichment.

bioRxiv (Cold Spring Harbor Laboratory), Journal Year: 2024, Volume and Issue: unknown

Published: Sept. 26, 2024

Ferroptosis is an iron-dependent form of controlled cell death and characterized by the formation lipid peroxides. Understanding gene expressions associated with ferroptosis critical for determining its function in illnesses potential therapeutic approaches. Despite significance, no computational model currently available to accurately quantify incident. FerroEnrich a sophisticated web-based tool built using R Shiny application enumerate occurrence based on relevant expressions. This at https://ferroenrich.shinyapps.io/ferroenrich/ processes input expression file identify genes that are resistant or prone ferroptosis, calculates index value dynamic colored heatmap network plot. manuscript describes design, operation usability FerroEnrich, including examples discussion impact research. vital researchers, allowing them explore analyze complicated data related ferroptosis.

Language: Английский