Virological and Pharmaceutical Properties of Clinically Relevant Phages DOI Creative Commons

Antonios-Periklis Panagiotopoulos,

Antonia P. Sagona,

Deny Tsakri

et al.

Antibiotics, Journal Year: 2025, Volume and Issue: 14(5), P. 487 - 487

Published: May 10, 2025

As antimicrobial resistance continues to undermine the efficacy of antibiotics, global medical community is increasingly turning alternative treatment modalities. Among these, phage therapy has re-emerged as a promising strategy for managing multidrug-resistant bacterial infections. Herein, we present and briefly discuss eight essential attributes clinically relevant phages therapy, which may be categorized broadly into virological pharmacological characteristics. Virological include broad host range, strictly lytic life cycle ability manage emergence phages. Comprehensive genomic proteomic characterization forms foundation selecting engineering such candidates, ensuring both safety predictability. From standpoint, should ideally show across formulations routes administration, favorable pharmacokinetics, stability during storage scalability in manufacturing. Advances analysis, artificial intelligence-driven selection formulation technologies have further accelerated translational potential therapy. By systematically addressing each these critical attributes, this work aims inform rational development therapeutic suitable integration clinical practice.

Language: Английский

Virological and Pharmaceutical Properties of Clinically Relevant Phages DOI Creative Commons

Antonios-Periklis Panagiotopoulos,

Antonia P. Sagona,

Deny Tsakri

et al.

Antibiotics, Journal Year: 2025, Volume and Issue: 14(5), P. 487 - 487

Published: May 10, 2025

As antimicrobial resistance continues to undermine the efficacy of antibiotics, global medical community is increasingly turning alternative treatment modalities. Among these, phage therapy has re-emerged as a promising strategy for managing multidrug-resistant bacterial infections. Herein, we present and briefly discuss eight essential attributes clinically relevant phages therapy, which may be categorized broadly into virological pharmacological characteristics. Virological include broad host range, strictly lytic life cycle ability manage emergence phages. Comprehensive genomic proteomic characterization forms foundation selecting engineering such candidates, ensuring both safety predictability. From standpoint, should ideally show across formulations routes administration, favorable pharmacokinetics, stability during storage scalability in manufacturing. Advances analysis, artificial intelligence-driven selection formulation technologies have further accelerated translational potential therapy. By systematically addressing each these critical attributes, this work aims inform rational development therapeutic suitable integration clinical practice.

Language: Английский

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