The Art of Finding the Right Drug Target: Emerging Methods and Strategies

Pharmacological Reviews, Journal Year: 2024, Volume and Issue: 76(5), P. 896 - 914

Published: June 12, 2024

Drug targets are specific molecules in biological tissues and body fluids that interact with drugs. target discovery is a key component of drug essential for the development new drugs areas such as cancer therapy precision medicine. Traditional in vitro or vivo methods time-consuming labour-intensive, limiting pace discovery. With modern methods, application various emerging technologies have greatly improved efficiency discovery, shortened cycle time reduced cost. This review provides comprehensive overview strategies, including computer-assisted approaches, affinity response stability, multiomics analysis, gene editing, NMD, discusses effectiveness limitations well their real cases. Through above related contents, general novel disease treatment strategies will be provided, theoretical basis provided those who engaged pharmaceutical science research. Significance Statement Target-based has been main approach to industry past three decades. based on or validation costly, Therefore, selection process crucial.

Language: Английский

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Screening Techniques for Drug Discovery in Alzheimer’s Disease

ACS Omega, Journal Year: 2024, Volume and Issue: 9(6), P. 6059 - 6073

Published: Feb. 5, 2024

Alzheimer's disease (AD) is a neurodegenerative disorder characterized by progressive and irreversible impairment of memory other cognitive functions the aging brain. Pathways such as amyloid beta neurotoxicity, tau pathogenesis neuroinflammatory have been used to understand AD, despite not knowing definite molecular mechanism which causes this disease. This review attempts summarize small molecules that target these pathways using various techniques involving high-throughput screening, modeling, custom bioassays, spectroscopic detection tools. Novel evolving screening methods developed advance drug discovery initiatives in AD research are also highlighted.

Language: Английский

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History, development, and principles of large language models: an introductory survey

AI and Ethics, Journal Year: 2024, Volume and Issue: unknown

Published: Oct. 14, 2024

Language: Английский

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Clinical translation of nanomedicine with integrated digital medicine and machine learning interventions

Colloids and Surfaces B Biointerfaces, Journal Year: 2024, Volume and Issue: 241, P. 114041 - 114041

Published: June 14, 2024

Language: Английский

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Assessment of risks, implications, and opportunities of waterborne neurotoxic pesticides

Journal of Environmental Sciences, Journal Year: 2022, Volume and Issue: 125, P. 735 - 741

Published: March 29, 2022

Language: Английский

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