Association Between Familial Inflammatory Diseases and Hidradenitis Suppurativa Severity: A Single‐Center Study DOI Open Access
Defne Özkoca, Adil Özcanlı, Elif Er Gülbezer

et al.

International Journal of Dermatology, Journal Year: 2025, Volume and Issue: unknown

Published: March 24, 2025

Hidradenitis suppurativa (HS) is a chronic, inflammatory skin disorder that profoundly affects patients' quality of life. It often accompanied by systemic diseases, including bowel disease (IBD) and rheumatologic conditions [1]. In this retrospective study, we analyzed 248 HS patients admitted to Koç University Hospital between January 2019 July 2024. Routine clinical assessments included detailed medical family histories, specifically concerning Behçet's disease, psoriasis, IBD, diseases. severity was categorized using the Hurley staging system. Statistical analyses were performed SPSS version 21; chi-square Fisher's exact tests used. A control group comprising 70 age- gender-matched individuals without also generated. p-values < 0.05 considered statistically significant. Of patients, mean age at onset 28.4 years. patient population, 60.1% male. The majority classified as stage 1 (42.7%) or 2 (39.9%), while 17.3% in 3(Table 1). Compared controls, had significantly higher rates metabolic syndrome, arthralgia ankylosing spondylitis, follicular occlusion tetrad. Notably, positive history HS, (p = 0.023), diseases 0.01) more common among patients. Patients with likely have 3 compared 0.047) (Table Our findings highlight plays significant role severity. Recent genetic studies identified several susceptibility loci shared other [2]. mutations MEFV gene encoding pyrin been suggesting pathways autoinflammatory This evidence further supports involvement specific pathways, such IL-1 TNF-α signaling, genetically predisposed individuals, contributing pathogenesis [3]. Previously, an association found vitamin D levels [4]. report deficiency prevalent comorbid 0.028). significance requires investigation larger cohorts. limitations our study include its design single-center nature. However, provide valuable insights into relationship some rheumatological which tendency for familial burden. These results suggest early identification management risk factors may help optimize treatment strategies. architecture inform therapeutic approaches. conclusion, highlights importance assessing appear influence Further multicenter prospective are needed clarify underlying molecular mechanisms linking course, potentially leading targeted We conducted research according World Medical Association Declaration Helsinki obtained approval local ethics committee. given informed consent use their data study. authors declare no conflicts interest. limited sample size major limitation research. datasets generated during and/or current available from corresponding author upon reasonable request.

Language: Английский

Hidradenitis suppurativa: BJD state-of-the-art review series DOI Creative Commons
J.R. Ingram

British Journal of Dermatology, Journal Year: 2025, Volume and Issue: 192(Supplement_1), P. i1 - i2

Published: Feb. 1, 2025

Language: Английский

Citations

0
Association Between Familial Inflammatory Diseases and Hidradenitis Suppurativa Severity: A Single‐Center Study DOI Open Access
Defne Özkoca, Adil Özcanlı, Elif Er Gülbezer

et al.

International Journal of Dermatology, Journal Year: 2025, Volume and Issue: unknown

Published: March 24, 2025

Hidradenitis suppurativa (HS) is a chronic, inflammatory skin disorder that profoundly affects patients' quality of life. It often accompanied by systemic diseases, including bowel disease (IBD) and rheumatologic conditions [1]. In this retrospective study, we analyzed 248 HS patients admitted to Koç University Hospital between January 2019 July 2024. Routine clinical assessments included detailed medical family histories, specifically concerning Behçet's disease, psoriasis, IBD, diseases. severity was categorized using the Hurley staging system. Statistical analyses were performed SPSS version 21; chi-square Fisher's exact tests used. A control group comprising 70 age- gender-matched individuals without also generated. p-values < 0.05 considered statistically significant. Of patients, mean age at onset 28.4 years. patient population, 60.1% male. The majority classified as stage 1 (42.7%) or 2 (39.9%), while 17.3% in 3(Table 1). Compared controls, had significantly higher rates metabolic syndrome, arthralgia ankylosing spondylitis, follicular occlusion tetrad. Notably, positive history HS, (p = 0.023), diseases 0.01) more common among patients. Patients with likely have 3 compared 0.047) (Table Our findings highlight plays significant role severity. Recent genetic studies identified several susceptibility loci shared other [2]. mutations MEFV gene encoding pyrin been suggesting pathways autoinflammatory This evidence further supports involvement specific pathways, such IL-1 TNF-α signaling, genetically predisposed individuals, contributing pathogenesis [3]. Previously, an association found vitamin D levels [4]. report deficiency prevalent comorbid 0.028). significance requires investigation larger cohorts. limitations our study include its design single-center nature. However, provide valuable insights into relationship some rheumatological which tendency for familial burden. These results suggest early identification management risk factors may help optimize treatment strategies. architecture inform therapeutic approaches. conclusion, highlights importance assessing appear influence Further multicenter prospective are needed clarify underlying molecular mechanisms linking course, potentially leading targeted We conducted research according World Medical Association Declaration Helsinki obtained approval local ethics committee. given informed consent use their data study. authors declare no conflicts interest. limited sample size major limitation research. datasets generated during and/or current available from corresponding author upon reasonable request.

Language: Английский

Citations

0