Journal of Cutaneous Pathology, Journal Year: 2024, Volume and Issue: unknown

Published: Nov. 3, 2024

ABSTRACT During the illustrious career of Martin C. Mihm Jr., MD, diagnosis melanoma underwent significant changes, to which he made many contributions. In early descriptions, melanomas were fungating tumor masses that obviously malignant, and highly lethal. seminal work by Dr. his mentor, Wallace H. Clark, phases development these neoplasms recognized distinguished from more advanced disease. It was generally believed stage melanoma, termed radial growth phase (RGP) characterized absence vertical (VGP) favorable microstaging attributes could be recognized, excised, cured, thus preventing However, strenuous efforts in this direction over several decades have resulted little or no change mortality, leading recognition neoplasms, at least, may not true biological malignancies, conclusion overdiagnosis commonly occurs disease, is defined as representing a neoplasm would had capacity cause death symptoms lifetime host. Although there other subsets category, an important category concentrated T1a lack VGP. If can with sensitive specific criteria, already available, changes terminology appropriate, recognizing some them low malignant potential, whereas others all for metastasis warrant use term “melanoma.”

Language: Английский