Improving the diagnostic performance of contrast-enhanced mammography through lesion conspicuity and enhancement quantification

European Radiology, Journal Year: 2025, Volume and Issue: unknown

Published: April 3, 2025

Language: Английский

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Comparative analysis of diagnostic performance of automatic breast ultrasound and spectral mammography as complementary methods to mammography examination

Polish Journal of Radiology, Journal Year: 2025, Volume and Issue: 90, P. 55 - 65

Published: Feb. 3, 2025

Purpose This single-centre study includes a comparative analysis of the diagnostic performance contrast-enhanced mammography (CEM) and automatic breast ultrasound (ABUS). The involved 81 patients with focal lesions, who underwent ABUS, full-field digital (FFDM), CEM. Material methods A total 169 lesions were found in patients, which 110 histopatholo­gically verified, 92 malignant, 5 B3 13 benign. On CEM 19 additional not visible on other imaging examinations found, as many 36 new detected ABUS. number multiple 106 from 65 FFDM, 88 highest correlation between lesion’s margin its histopathological character was FFDM (p < 0.00), then ABUS = 0.038), lowest 0.043). Compliance determining lesions’ size comparing to histopathology gold standard for 0.258) lower 0.012). Results sensitivity was, respectively: 80.43, 90.22, 93.48; specificity: 27.78, 11.11, 11.11; positive predictive value (PPV): 85.06, 83.84, 84.31; negative (NPV): 21.74, 18.18, 25; accuracy: 71.82, 77.27, 80. accuracy combination were, respectively, 100 0.02) 84.55 (AUC 0.947) + 93.48 0.25) 79.09 0.855). Conclusions confirms that both may serve valuable complementary method FFDM.

Language: Английский

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Morphodynamic Features of Contrast-Enhanced Mammography and Their Correlation with Breast Cancer Histopathology

Journal of Imaging, Journal Year: 2025, Volume and Issue: 11(3), P. 80 - 80

Published: March 13, 2025

Contrast-enhanced mammography (CEM) combines morphological and functional imaging, enhancing breast cancer (BC) diagnosis. This study investigates the relationship between CEM morphodynamic features histopathological characteristics of BC. In this prospective study, 50 female patients (mean age: 57.2 ± 13.7 years) with BI-RADS 4–5 lesions underwent followed by surgical excision December 2022 May 2024. Low-energy recombined images were analyzed for composition, lesion characteristics, enhancement patterns, while evaluation included tumor size, histotype, grade, lymphovascular invasion, immunophenotype. Spearman rank correlation multivariable regression analysis used to evaluate findings characteristics. Tumor size on strongly correlated (ρ = 0.788, p < 0.001) was associated high-grade (p 0.017). Non-circumscribed margins linked a Luminal-B subtype 0.001), high conspicuity triple-negative BC larger tumors 0.517, 0.001). Background parenchymal negatively age −0.286, 0.049). provides critical insights into BC, demonstrating significant imaging These highlight CEM’s potential as reliable tool estimation, characterization, prognostic assessment, suggesting its role an alternative MRI, particularly contraindications.

Language: Английский

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Evaluation of contrast-enhanced mammography (CEM) in the preoperative staging of breast cancer: large-scale single center experience, update to 1005 cases

La radiologia medica, Journal Year: 2025, Volume and Issue: unknown

Published: March 28, 2025

Language: Английский

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Emerging nanoparticle-based x-ray imaging contrast agents for breast cancer screening

Nanomedicine, Journal Year: 2025, Volume and Issue: unknown, P. 1 - 18

Published: April 22, 2025

Breast cancer is one of the most common types cancer, however, preventive screening has contributed to a significant reduction in mortality over past four decades. The first-line methods for breast such as mammography and tomosynthesis, are x-ray-based modalities. Unfortunately, their detection rates low patients with dense breasts. These, other high-risk women, now encouraged receive supplemental screening. imaging diverse, including ultrasound, MRI, nuclear imaging, X-ray-based modalities CT contrast-enhanced mammography/tomosynthesis. Due cost wide availability, see clinical use worldwide. These techniques benefit from contrast agents, which currently iodinated small molecules designed purposes. Consequently, developing new agents that specifically interest. This review describes these nanoparticle-based being researched enhanced performance. relevant parameters agent design evaluated, generation potential biointeractions. Iodinated discussed comparison. Nanoparticles covered include silver sulfide, telluride, gold, bismuth sulfide-based among others. Finally, perspectives on future developments this field offered.

Language: Английский

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A multicentric study of radiomics and artificial intelligence analysis on contrast-enhanced mammography to identify different histotypes of breast cancer

La radiologia medica, Journal Year: 2024, Volume and Issue: 129(6), P. 864 - 878

Published: May 17, 2024

Language: Английский

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Validation of Contrast-Enhanced Mammography as Breast Imaging Modality Compared to Standard Mammography and Digital Breast Tomosynthesis

Diagnostics, Journal Year: 2024, Volume and Issue: 14(14), P. 1575 - 1575

Published: July 21, 2024

Contrast-enhanced mammography (CEM) is a relatively new imaging technique that allows morphologic, anatomic and functional of the breast. The aim our study was to validate contrast-enhanced compared (MMG) digital breast tomosynthesis (DBT) in daily clinical practice. This retrospective included 316 consecutive patients who underwent MMG, DBT CEM at Centre for Prevention Diagnosis Chronic Diseases Primorsko-goranska County. Two radiologists independently analyzed image data, without available anamnestic information possibility comparison with previous images, determine presence suspicious lesions their morphological features according established criteria Breast Imaging Reporting Data System (BI-RADS) lexicon. diagnostic value assessed by ROC analysis. interobserver agreement excellent. showed higher accuracy terms sensitivity specificity MMG DBT, reporting time significantly shorter, findings resulted lower proportion equivocal (BI-RADS 0), suggesting fewer additional procedures. In conclusion, achieves high while maintaining simplicity, reproducibility applicability complex settings.

Language: Английский

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Contrast Enhancement in Breast Cancer: Magnetic Resonance vs. Mammography: A 10-Year Systematic Review

Diagnostics, Journal Year: 2024, Volume and Issue: 14(21), P. 2400 - 2400

Published: Oct. 28, 2024

PURPOSE: Contrast Enhancement Magnetic Resonance (CEMR) and Contrast-Enhanced Mammography (CEM) are important diagnostic tools to evaluate breast cancer patients, both objects of interest in the literature. The purpose this systematic review was select publications from last ten years order literature contributions related frequency contrast agents used, administration techniques presence adverse reactions. METHODS: We have selected, according PRISMA statement, reviewed on Pub Med period 1 January 2012 31 December 2022. search engine activated using following keywords: “CESM”, “CEM”, “CEDM”, “Contrast mammography” for CEM, “DCE-MRI”, MRI” CEMR, excluding reviews, book chapters meta-analyses. From total number publications, we made a preliminary selection based titles abstracts excluded all articles published languages other than English experimental studies performed surgical specimen or animal population, as well which extended version not available. Two readers evaluated compiled pre-compiled form accordingly. RESULTS: After collection 571 CEM 118 were relating an overall population 21,178 patients. 3063 CEMR 356 45,649 patients selected. most used Iohexol (39.83%) Gadopentetic acid (Gd-DTPA) (32.5%). Regarding protocol, 84.7% cases dose 1.5 mL/kg with infusion rate 2–3 mL/s. 71% mmol/kg at 2–4 Twelve out reported allergic reactions, involving 29 (0.13%). In DCE-MRI, only one two (0.004%). No severe reactions observed either cohort exams. CONCLUSIONS: essential methods diseases. However, analysis, although there preferences uses agent (Iohexol CESM, G-DTPA CEMR), wide range molecules still methods, different protocols. Based collected data, it is possible state that safe, no our evaluation.

Language: Английский

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Contrast-enhanced mammography vs MRI: Which breast imaging modality leads in lesion detection?

European Radiology, Journal Year: 2024, Volume and Issue: unknown

Published: Dec. 19, 2024

Language: Английский

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