Fading Blue: Exploring the Causes of Locus Coeruleus Damage Across the Lifespan DOI Creative Commons
Alessandro Galgani,

Marco Scotto,

Ugo Faraguna

et al.

Antioxidants, Journal Year: 2025, Volume and Issue: 14(3), P. 255 - 255

Published: Feb. 22, 2025

Locus Coeruleus (LC) is a brain nucleus that involved in variety of key functions (ranging from attention modulation to sleep-wake cycle regulation, memory encoding); its proper function necessary both during development and for integrity maintenance, at the microscale macroscale level. Due their specific intrinsic extrinsic features, LC cells are considered particularly susceptible damage concerning insults. This explains involvement degenerative diseases not only adults (in context neurodegenerative disease, mainly), but also children relation early hypoxic Down's Syndrome, among others). In this narrative review, we dissect potential mechanisms through which affected different diseases, with special emphasis on high rate activity it subjected oxidative stress associated it. Further research aimed deepening our understanding these needed enable strategies future could slow down degeneration subjects predisposed disorders.

Language: Английский

Noradrenergic alterations in Parkinson’s disease: a combined 11C-yohimbine PET/neuromelanin MRI study DOI Creative Commons
Chloé Laurencin, Sophie Lancelot,

Sarah Brosse

et al.

Brain, Journal Year: 2023, Volume and Issue: 147(4), P. 1377 - 1388

Published: Oct. 3, 2023

Abstract Degeneration of the noradrenergic system is now considered a pathological hallmark Parkinson’s disease, but little known about its consequences in terms parkinsonian manifestations. Here, we evaluated two aspects using multimodal vivo imaging patients with disease and healthy controls: pigmented cell bodies locus coeruleus neuromelanin sensitive MRI; density α2-adrenergic receptors (ARs) PET 11C-yohimbine. Thirty 30 age- sex-matched control subjects were included. The characteristics patients’ symptoms assessed Movement Disorder Society Unified Disease Rating Scale (MDS-UPDRS). Patients showed reduced signal intensity compared controls diminished 11C-yohimbine binding widespread cortical regions, including motor cortex, as well insula, thalamus putamen. Clinically, neuronal loss was correlated (bradykinesia, fluctuations, tremor) non-motor (fatigue, apathy, constipation) symptoms. A reduction α2-AR availability associated tremor, while putamen, insula superior temporal gyrus anxiety. These results highlight multifaceted alteration since degeneration found to be partly uncoupled. findings raise important issues dysfunction that may encourage search for new drugs targeting this system, α2-ARs, treatment disease.

Language: Английский

Citations

12
Exploring Parkinson’s Disease-Associated Depression: Role of Inflammation on the Noradrenergic and Serotonergic Pathways DOI Creative Commons
Tuane Bazanella Sampaio, Marissa Giovanna Schamne, Jean Rodrigo Santos

et al.

Brain Sciences, Journal Year: 2024, Volume and Issue: 14(1), P. 100 - 100

Published: Jan. 20, 2024

Parkinson’s disease (PD) is a multifactorial disease, with genetic and environmental factors contributing to the onset. Classically, PD movement disorder characterized by loss of dopaminergic neurons in nigrostriatal pathway intraneuronal aggregates mainly constituted protein α-synuclein. However, patients also display non-motor symptoms, including depression, which have been linked functional abnormalities non-dopaminergic neurons, serotonergic noradrenergic ones. Thus, through this comprehensive literature review, we shed light on impairment depression PD, focusing putative involvement inflammatory mechanisms.

Language: Английский

Citations

4
Lasting Impact: Exploring the Brain Mechanisms that Link Traumatic Brain Injury to Parkinson’s Disease DOI Creative Commons
Samantha Edwards, Frances Corrigan, Lyndsey E. Collins‐Praino

et al.

Molecular Neurobiology, Journal Year: 2025, Volume and Issue: unknown

Published: Feb. 1, 2025

Abstract Development of Parkinson’s Disease (PD) is linked with a history traumatic brain injury (TBI), although the mechanisms driving this remain unclear. Of note, many key parallels have been identified between pathologies PD and TBI; in particular, characterised by loss dopaminergic neurons from substantia nigra (SN), accompanied broader changes to signalling, disruption Locus Coeruleus (LC) noradrenergic system, accumulation aggregated α-synuclein Lewy Bodies, which spreads stereotypical pattern throughout brain. Widespread disruptions systems, including progressive neuronal SN LC, observed acutely following injury, some also chronically TBI patients preclinical models . Furthermore, expression are seen both brain, detailed characterisation these spread pathology limited. In review, we detail current literature regarding particular focus on how may predispose individuals prolonged neurodegeneration, particularly development PD. While it increasingly clear that risk factor for PD, significant gaps understanding neurodegenerative TBI, chronic manifestations injury.

Language: Английский

Citations

0
Locus coeruleus neuromelanin, cognitive dysfunction, and brain metabolism in multiple system atrophy DOI Creative Commons
Jacopo Pasquini, Hilmar P. Sigurdsson, Michael Firbank

et al.

Journal of Neurology, Journal Year: 2025, Volume and Issue: 272(3)

Published: Feb. 11, 2025

Abstract Background Cognitive dysfunction is increasingly recognized in multiple system atrophy (MSA). Locus coeruleus (LC) integrity associated with cognitive performance both healthy controls (HC) and neurodegenerative conditions such as Parkinson’s disease (PD). Furthermore, cortical glucose hypometabolism impaired MSA. However, knowledge about LC sub-regional degeneration its association metabolism lacking. Objective To investigate involvement impairment brain Methods Eleven MSA, eighteen PD, HC participants were included the study. Neuromelanin-sensitive MRI was used to determine rostral, middle caudal neuromelanin signals. Brain investigated [ 18 F]Fluorodeoxyglucose PET (FDG-PET). The Montreal Assessment (MoCA) a measure of global cognition. Results Middle signal significantly reduced MSA t (43) = 3.70, corrected- p 0.004] PD 2.63, 0.041] compared HC, while only 2.82, 0.030]. In decreased rostral lower MoCA scores ( ρ 0.760, 0.006) which, turn, frontal cortex metabolism. An between found exploratory analyses. Conclusion Loss parts being targeted. Rostral loss scores. This pathophysiological link should be further noradrenergic transmission amenable pharmacological manipulation.

Language: Английский

Citations

0
Fading Blue: Exploring the Causes of Locus Coeruleus Damage Across the Lifespan DOI Creative Commons
Alessandro Galgani,

Marco Scotto,

Ugo Faraguna

et al.

Antioxidants, Journal Year: 2025, Volume and Issue: 14(3), P. 255 - 255

Published: Feb. 22, 2025

Locus Coeruleus (LC) is a brain nucleus that involved in variety of key functions (ranging from attention modulation to sleep-wake cycle regulation, memory encoding); its proper function necessary both during development and for integrity maintenance, at the microscale macroscale level. Due their specific intrinsic extrinsic features, LC cells are considered particularly susceptible damage concerning insults. This explains involvement degenerative diseases not only adults (in context neurodegenerative disease, mainly), but also children relation early hypoxic Down's Syndrome, among others). In this narrative review, we dissect potential mechanisms through which affected different diseases, with special emphasis on high rate activity it subjected oxidative stress associated it. Further research aimed deepening our understanding these needed enable strategies future could slow down degeneration subjects predisposed disorders.

Language: Английский

Citations

0