Association between brain resting-state functional activities and migraine: a bidirectional mendelian randomization study DOI Creative Commons
Qian Lu, Zhenyu Jia, Hong Gu

et al.

Scientific Reports, Journal Year: 2024, Volume and Issue: 14(1)

Published: Oct. 12, 2024

Researchers have conducted extensive research on the correlation between brain resting-state functional activities (RSFA) and migraine. However, we still do not fully understand exact nature of causal relationship these RSFA We a bidirectional two-sample Mendelian randomization (MR) study to investigate association migraine RSFA. gathered summary statistics from genome-wide studies for 191 magnetic resonance imaging phenotypes. employed various analytical methods MR analyses. This included inverse variance weighted, weighted median, Egger, constrained maximum likelihood approaches. also pleiotropy heterogeneity analyses evaluate robustness reliability. found connectivity default mode central executive network (OR = 1.39, p 4.77 × 10−4, FDR corrected value 0.040) intensity spontaneous activity in calcarine or lingual gyrus within visual 0.74, 5.94 having effect risk Our analysis provided genetic support networks, which may play an important role influencing susceptibility.

Language: Английский

Genetics of migraine: where are we now? DOI Creative Commons
Lou Grangeon, Kristin Sophie Lange, Marta Waliszewska‐Prosół

et al.

The Journal of Headache and Pain, Journal Year: 2023, Volume and Issue: 24(1)

Published: Feb. 20, 2023

Abstract Migraine is a complex brain disorder explained by the interaction of genetic and environmental factors. In monogenic migraines, including familial hemiplegic migraine with aura associated hereditary small-vessel disorders, identified genes code for proteins expressed in neurons, glial cells, or vessels, all which increase susceptibility to cortical spreading depression. The study migraines has shown that neurovascular unit plays prominent role migraine. Genome-wide association studies have numerous variants each result only small overall risk. more than 180 known belong several networks “pro-migraine” molecular abnormalities, are mainly neuronal vascular. Genetics also highlighted importance shared factors between its major co-morbidities, depression high blood pressure. Further still needed map loci then understand how these genomic lead cell phenotypes.

Language: Английский

Citations

79
Genetics of migraine: complexity, implications, and potential clinical applications DOI
Heidi G. Sutherland, Bronwyn Jenkins, Lyn R. Griffiths

et al.

The Lancet Neurology, Journal Year: 2024, Volume and Issue: 23(4), P. 429 - 446

Published: March 18, 2024

Language: Английский

Citations

14
Causal relationships between migraine and microstructural white matter: a Mendelian randomization study DOI Creative Commons
Lei Zhao, Wenhui Zhao, Verneri Anttila

et al.

The Journal of Headache and Pain, Journal Year: 2023, Volume and Issue: 24(1)

Published: Feb. 16, 2023

Migraine is a disabling neurological disorder with the pathophysiology yet to be understood. The microstructural alteration in brain white matter (WM) has been suggested related migraine recent studies, but these evidence are observational essentially and cannot infer causal relationship. present study aims reveal relationship between WM using genetic data Mendelian randomization (MR).

Language: Английский

Citations

21
Migraine: Advances in the Pathogenesis and Treatment DOI Creative Commons

Horia Pleș,

Ioan Alexandru Florian,

Teodora-Larisa Timiș

et al.

Neurology International, Journal Year: 2023, Volume and Issue: 15(3), P. 1052 - 1105

Published: Aug. 31, 2023

This article presents a comprehensive review on migraine, prevalent neurological disorder characterized by chronic headaches, focusing their pathogenesis and treatment advances. By examining molecular markers leveraging imaging techniques, the research identifies key mechanisms triggers in migraine pathology, thereby improving our understanding of its pathophysiology. Special emphasis is given to role calcitonin gene-related peptide (CGRP) development. CGRP not only contributes symptoms but also represents promising therapeutic target, with inhibitors showing effectiveness management. The further explores traditional medical treatments, scrutinizing mechanisms, benefits, limitations commonly prescribed medications. provides segue into an analysis emerging strategies potential enhance Finally, paper delves neuromodulation as innovative modality. Clinical studies indicating management are reviewed, advantages this technique discussed. In summary, aims present novel possibilities that could revolutionize patient care.

Language: Английский

Citations

20
New perspectives on migraine treatment: a review of the mechanisms and effects of complementary and alternative therapies DOI Creative Commons
Xiaoli Song, Qian Zhu,

Lanqian Su

et al.

Frontiers in Neurology, Journal Year: 2024, Volume and Issue: 15

Published: May 9, 2024

Migraine is a prevalent and disabling neurovascular disorder, with women being more susceptible, characterized by unilateral throbbing headache, often accompanied nausea vomiting, associated various comorbidities such as brain cardiovascular diseases, which can have serious impact on quality of life. Although nonsteroidal anti-inflammatory drugs (NSAIDs) are the main first-line medications for treatment pain, long-term use leads to side effects drug addiction, emphasizes need investigate alternative pain management strategies fewer adverse effects. Complementary medicine viable intervention used in conjunction traditional medications, including acupuncture, herbs, moxibustion, transcutaneous electrical stimulation, bio-supplements, acupressure, offer non-pharmacological alternatives that now options. This review focuses mechanistic doctrine migraine generation role potential mechanisms Alternative Therapies (CAT) migraine, summarizes research evidences CAT an adjunct or conventional therapies novel (calcitonin gene-related peptide (CGRP) antagonists pituitary adenylyl cyclase-activating (PACAP) antagonists) aim evaluating adjunctive treatment, thereby providing broader perspective design programs effective management.

Language: Английский

Citations

6
Shared molecular genetic factors influence subcortical brain morphometry and Parkinson’s disease risk DOI Creative Commons
Luis M. García‐Marín, Paula Reyes‐Pérez, Santiago Díaz-Torres

et al.

npj Parkinson s Disease, Journal Year: 2023, Volume and Issue: 9(1)

Published: May 10, 2023

Parkinson's disease (PD) is a late-onset and genetically complex neurodegenerative disorder. Here we sought to identify genes molecular pathways underlying the associations between PD volume of ten brain structures measured through magnetic resonance imaging (MRI) scans. We leveraged genome-wide genetic data from several cohorts, including International Disease Genomics Consortium (IPDG), UK Biobank, Adolescent Brain Cognitive Development (ABCD) study, Cohorts for Heart Aging Research in Genomic Epidemiology (CHARGE), Enhancing Neuroimaging Genetics Meta-Analyses (ENIGMA), 23andMe. observed significant positive correlations intracranial subcortical volumes. Genome-wide association studies (GWAS) - pairwise analyses identified 210 genomic segments with shared aetiology at least one these structures. Pathway enrichment results highlight potential links chronic inflammation, hypothalamic-pituitary-adrenal pathway, mitophagy, disrupted vesicle-trafficking, calcium-dependent, autophagic pathways. Investigations putative causal effects suggest that larger putamen could influence risk, independently (ICV) on PD. Our findings variants influencing volumes, possibly during earlier stages life, risk developing later life.

Language: Английский

Citations

12
Association between brain structures and migraine: A bidirectional Mendelian randomization study DOI Creative Commons
Xiaoming Guo,

Dingkun Wang,

Caidi Ying

et al.

Frontiers in Neuroscience, Journal Year: 2023, Volume and Issue: 17

Published: March 3, 2023

Accumulating evidence of clinical and neuroimaging studies indicated that migraine is related to brain structural alterations. However, it still not clear whether the associations alterations with are likely be causal, or could explained by reverse causality confounding.We carried on a bidirectional Mendelian randomization analysis in order identify causal relationship between structures risk. Summary-level data independent variants used as instruments came from large genome-wide association total surface area average thickness cortex (33,992 participants), gray matter volume (8,428 white hyperintensities (50,970 hippocampal (33,536 (102,084 cases 771,257 controls).We identified suggestive decreased (OR = 0.85; 95% CI, 0.75-0.96; P 0.007), 0.74; 0.55-1.00; 0.047) higher We did find any significant volume, cortical thickness, migraine. No supporting was found MR analysis.We provided causally associated

Language: Английский

Citations

11
Exploring the Link Between C‐Reactive Protein Change and Stroke Risk: Insights From a Prospective Cohort Study and Genetic Evidence DOI Creative Commons

Yitong Ling,

Shiqi Yuan, Hongtao Cheng

et al.

Journal of the American Heart Association, Journal Year: 2025, Volume and Issue: unknown

Published: March 26, 2025

Background Previous research on how changes in CRP (C‐reactive protein) levels predict stroke risk is limited. This study aimed to examine the association between change and of its subtypes. Methods Results Based UK Biobank data, we investigated subtypes with Cox proportional hazards regression analysis. We further performed genetic analyses including correlation, pairwise genome‐wide study, polygenic score. Our involved 14 754 participants a median follow‐up time 10.4 years. After categorizing by percentage making adjustments for potential confounders, it was observed that those an elevated had higher any (hazard ratio [HR], 1.44 [95% CI, 1.12–1.85]) ischemic (HR, 1.65 1.24–2.18]). categorization types adjustment group became high level any‐stroke 1.45 1.04–2.02]), remained at facing greatest 1.74 1.30–2.33]). Similar trends were stroke. The also heightened hemorrhagic 1.91 1.07–3.44]). Genetic analysis showed significant correlation (r g , 0.257; r _ P =2.39E‐07). Pairwise identified 5 shared genomic regions Polygenic score or remaining have highest Conclusions Both are related levels, while only levels.

Language: Английский

Citations

0
Migräne DOI
Hartmut Göbel

Springer eBooks, Journal Year: 2025, Volume and Issue: unknown, P. 185 - 515

Published: Jan. 1, 2025

Citations

0
Genetic Links Between Subcortical Brain Morphometry and Suicide Attempt Risk in Children and Adults DOI Creative Commons
Zuriel Ceja, Luis M. García‐Marín, I‐Tzu Hung

et al.

Human Brain Mapping, Journal Year: 2025, Volume and Issue: 46(7)

Published: May 1, 2025

ABSTRACT Genome‐wide association studies (GWAS) have uncovered genetic variants associated with suicide attempt (SA) risk and regional brain volumes (RBVs). However, the extent of their overlap remains unclear. To address this, we investigated whether architecture SA various RBVs (i.e., caudate nucleus, hippocampus, brainstem, ventral diencephalon, thalamus, globus pallidus, putamen, nucleus accumbens, amygdala intracranial volume (ICV)) was shared. We leveraged GWAS summary statistics from largest available datasets on ( N = 958,896) subcortical 74,898). Using linkage disequilibrium score regression, estimated genome‐wide correlations between individual RBVs. GWAS‐pairwise analyses identified genomic segments both RBVs, followed by functional annotation. Additionally, examined polygenic scores (PGS) for were ICV structure phenotypes in youth European ancestry 5276) Adolescent Brain Cognitive Development (ABCD) study. Linkage regression results indicated a significant correlation (rG −0.10, p ‐value 1.9 × 10–3). annotation revealed 10 at least one RBV (thalamus, putamen nucleus). After adjusting multiple tests, PGS analysis that higher significantly smaller right accumbens b −7.05, 0.018). Our findings highlight negative amongst adults suggest different neural correlates across developmental periods. This study advances our understanding shared underpinnings structure, potentially informing future research clinical interventions.

Language: Английский

Citations

0