Functional to structural plasticity in unilateral sudden sensorineural hearing loss: neuroimaging evidence DOI Creative Commons
Yuting Li,

Ke Bai,

G D Li

et al.

NeuroImage, Journal Year: 2023, Volume and Issue: 283, P. 120437 - 120437

Published: Nov. 3, 2023

A cortical plasticity after long-duration single side deafness (SSD) is advocated with neuroimaging evidence while little known about the short-duration SSDs. In this case-cohort study, we recruited unilateral sudden sensorineural hearing loss (SSNHL) patients and age-, gender-matched health controls (HC), followed by comprehensive analyses. The primary outcome measures were temporal alterations of varied dynamic functional network connectivity (dFNC) states, neurovascular coupling (NVC) brain region volume at different stages SSNHL. secondary pure-tone audiograms SSNHL before treatment. total 38 (21 [55%] male; mean [standard deviation] age, 45.05 [15.83] years) 44 HC (28 [64%] 43.55 [12.80] enrolled. categorized into subgroups based on time from disease onset to initial magnetic resonance imaging scan: early- (n = 16; 1-6 days), intermediate- 9; 7-13 late- stage 13; 14-30 days) groups. We first identified slow state transitions between dFNC states early-stage SSNHL, then revealed decreased NVC restricted auditory cortex late-stage Finally, a significantly left medial superior frontal gyrus (SFGmed) was observed only in cohort. Furthermore, SFGmed robustly correlated both duration patient prognosis. Our study offered for evolvement structural less than 1 month, which may explain, perspective, why have better therapeutic responses recovery.

Language: Английский

A Soluble Epoxide Hydrolase Inhibitor Improves Cerebrovascular Dysfunction, Neuroinflammation, Amyloid Burden, and Cognitive Impairments in the hAPP/PS1 TgF344-AD Rat Model of Alzheimer’s Disease DOI Open Access
Xing Fang,

Jane J. Border,

Huawei Zhang

et al.

International Journal of Molecular Sciences, Journal Year: 2025, Volume and Issue: 26(6), P. 2433 - 2433

Published: March 8, 2025

Alzheimer’s disease (AD) is an increasing global healthcare crisis with few effective treatments. The accumulation of amyloid plaques and hyper-phosphorylated tau are thought to underlie the pathogenesis AD. However, current studies have recognized a prominent role cerebrovascular dysfunction in We recently reported that SNPs soluble epoxide hydrolase (sEH) linked AD human genetic long-term administration sEH inhibitor attenuated cerebral vascular cognitive rat model mechanisms linking changes function neuroprotective actions inhibitors remain be determined. This study investigated effects inhibitor, 1-(1-Propanoylpiperidin-4-yl)-3-[4-(trifluoromethoxy)phenyl]urea (TPPU), on neurovascular coupling, blood–brain barrier (BBB) function, neuroinflammation, hAPP/PS1 TgF344-AD observed predominant β-amyloid brains 9–10-month-old rats TPPU treatment for three months reduced burden. functional hyperemic response whisker stimulation was rats, normalized response. TPPU, mitigated capillary rarefaction, BBB leakage, activation astrocytes microglia rats. increased expression pre- post-synaptic proteins loss hippocampal neurons impairments which confirmed transcriptome GO analysis. These results suggest could novel therapeutic strategy

Language: Английский

Citations

0
Sleep deprivation impairs neurovascular coupling and cerebral vasomotor reactivity DOI Creative Commons

Krisztina Szonja Rab-Bábel,

Dóra Sulina,

CH Daniel

et al.

Scientific Reports, Journal Year: 2025, Volume and Issue: 15(1)

Published: March 19, 2025

Sleep deficiency increases the risk of cerebrovascular diseases. However, effects sleep deprivation (SD) on cerebral blood flow have been poorly studied. We examined effect 24-h SD resting posterior artery (PCA) and middle (MCA) velocities (FV), visually evoked FV response in PCA (neurovascular coupling), hypercapnia-induced MCA (cerebral vasoreactivity). Visual potential (VEP) transcranial Doppler examinations were performed 25 healthy adults before after SD. Cerebral vasoreactivity was measured by breath-holding test left right MCA. The evaluated PCA. There a tendency for increased mean (p = 0.08) 0.07) Both increase significantly lower than SD, however, no change VEP amplitudes found. Our study suggested that impaired functional stimulation-evoked not due to reduced neuronal activation, but probably decreased vasodilatory response. Negative hemodynamics also demonstrated vasoreactivity.

Language: Английский

Citations

0
Altered neurovascular coupling in depression with childhood maltreatment DOI

Sangni Liu,

Dandan Fan,

Cancan He

et al.

Progress in Neuro-Psychopharmacology and Biological Psychiatry, Journal Year: 2025, Volume and Issue: unknown, P. 111348 - 111348

Published: April 1, 2025

Language: Английский

Citations

0
Brain pericyte biology: from physiopathological mechanisms to potential therapeutic applications in ischemic stroke DOI Creative Commons
Jiaqi Fu, Huazheng Liang, Ping Yuan

et al.

Frontiers in Cellular Neuroscience, Journal Year: 2023, Volume and Issue: 17

Published: Sept. 14, 2023

Pericytes play an indispensable role in various organs and biological processes, such as promoting angiogenesis, regulating microvascular blood flow, participating immune responses. Therefore, this review, we will first introduce the discovery development of pericytes, identification methods functional characteristics, then focus on brain one hand, to summarize functions pericytes under physiological conditions, mainly discussing from aspects stem cell contractile characteristics paracrine characteristics; other pathological taking ischemic stroke example. Finally, discuss analyze application therapeutic targets, providing research basis direction for future diseases, especially treatment.

Language: Английский

Citations

10
Functional to structural plasticity in unilateral sudden sensorineural hearing loss: neuroimaging evidence DOI Creative Commons
Yuting Li,

Ke Bai,

G D Li

et al.

NeuroImage, Journal Year: 2023, Volume and Issue: 283, P. 120437 - 120437

Published: Nov. 3, 2023

A cortical plasticity after long-duration single side deafness (SSD) is advocated with neuroimaging evidence while little known about the short-duration SSDs. In this case-cohort study, we recruited unilateral sudden sensorineural hearing loss (SSNHL) patients and age-, gender-matched health controls (HC), followed by comprehensive analyses. The primary outcome measures were temporal alterations of varied dynamic functional network connectivity (dFNC) states, neurovascular coupling (NVC) brain region volume at different stages SSNHL. secondary pure-tone audiograms SSNHL before treatment. total 38 (21 [55%] male; mean [standard deviation] age, 45.05 [15.83] years) 44 HC (28 [64%] 43.55 [12.80] enrolled. categorized into subgroups based on time from disease onset to initial magnetic resonance imaging scan: early- (n = 16; 1-6 days), intermediate- 9; 7-13 late- stage 13; 14-30 days) groups. We first identified slow state transitions between dFNC states early-stage SSNHL, then revealed decreased NVC restricted auditory cortex late-stage Finally, a significantly left medial superior frontal gyrus (SFGmed) was observed only in cohort. Furthermore, SFGmed robustly correlated both duration patient prognosis. Our study offered for evolvement structural less than 1 month, which may explain, perspective, why have better therapeutic responses recovery.

Language: Английский

Citations

10