Choroid plexus enlargement is associated with future periventricular neurodegeneration in multiple sclerosis

Multiple Sclerosis and Related Disorders, Journal Year: 2024, Volume and Issue: 87, P. 105668 - 105668

Published: May 6, 2024

Language: Английский

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Multiparametric Characterization and Spatial Distribution of Different MS Lesion Phenotypes

American Journal of Neuroradiology, Journal Year: 2024, Volume and Issue: 45(8), P. 1166 - 1174

Published: May 30, 2024

BACKGROUND AND PURPOSE:

MS lesions exhibit varying degrees of axonal and myelin damage. A comprehensive description lesion phenotypes could contribute to an improved radiologic evaluation smoldering inflammation remyelination processes. This study aimed identify in vivo distinct types using quantitative susceptibility mapping mapping–weighted imaging characterize them through T1-relaxometry, mapping, diffusion MR imaging. The spatial distribution relation ventricular CSF was investigated.

MATERIALS METHODS:

53 individuals were categorized into iso- or hypointense lesions, hyperintense paramagnetic rim on the basis their appearance alone, according published criteria, with additional support Susceptibility values, T1-relaxation times, free water fractions, intracellular volume fraction, orientation dispersion index compared among phenotypes. distance geometric center each from calculated.

RESULTS:

Eight hundred ninety-six underwent categorization process novel use images, which revealed microvasculature details, led us re-allocate several different categories, resulting a 35.6% decrease number 22.5% 17.2% increase respect based only. outcome joint that 44.4% 47.9% 7.7% lesions. worsening gradient observed faction, fraction. Paramagnetic located closer than associated more severe disease course.

CONCLUSIONS:

Quantitative allow classification phenotypes, characterized by levels loss distribution. Hyperintense have most microstructural damage, often periventricular WM

Language: Английский

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Microstructural Damage and Repair in the Spinal Cord of Patients With Early Multiple Sclerosis and Association With Disability at 5 Years

Neurology Neuroimmunology & Neuroinflammation, Journal Year: 2024, Volume and Issue: 12(1)

Published: Nov. 21, 2024

The dynamics of microstructural spinal cord (SC) damage and repair in people with multiple sclerosis (pwMS) their clinical relevance have yet to be explored. We set out describe patient-specific profiles SC change during the first year after MS diagnosis investigate associations disability atrophy at 5 years. performed a longitudinal monocentric cohort study among patients relapsing-remitting MS: relapse <1 year, no month, high initial severity on MRI (>9 T2 lesions brain and/or myelitis). pwMS age-matched healthy controls (HCs) underwent cervical magnetization transfer (MT) imaging baseline 1 for pwMS. Based HC data, MT ratio z-score maps were computed each person MS. An index was calculated as proportion voxels classified normal identified damaged year. Similarly, an also (voxels year). Linear models including these indices or cross-sectional area (CSA) between years implemented. Thirty-seven 19 HCs included. observed considerable variability extent (0%-58% voxels). over (0%-31% 0%-20%), 18 showing predominance repair. associated positively Expanded Disability Status Scale score (r = 0.504, p 0.002) negatively CSA -0.416, 0.02) years, independent lesion volume. People early exhibited heterogeneous Progression progression later. These results indicate potential prevent

Language: Английский

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Understanding the Role of the Choroid Plexus in Multiple Sclerosis as an MRI Biomarker of Disease Activity

Neurology, Journal Year: 2022, Volume and Issue: 100(9), P. 405 - 406

Published: Dec. 21, 2022

Language: Английский

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Carnosine synthase deficiency aggravates neuroinflammation in multiple sclerosis

Progress in Neurobiology, Journal Year: 2023, Volume and Issue: 231, P. 102532 - 102532

Published: Sept. 27, 2023

Language: Английский

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