Algorithm of diagnosis and treatment of Gilles de la Tourette syndrome and tic disorder, adapted for the Republic of Moldova: a review DOI Open Access
Valeria Sajin

Moldovan Journal of Health Sciences, Journal Year: 2023, Volume and Issue: 4, P. 54 - 67

Published: Dec. 1, 2023

Introduction. In the last years high prevalence of tic disorder and Gilles de la Tourette syndrome (GTS) was confirmed. The available therapies can temporarily suppress tics, but not eliminate them definitively, that implies a strict individual assessment risks benefits for every patient. recent scientific studies confirmed efficiency some diagnostic therapeutic options, infirmed other ones. Thus, qualitative analysis adjustment recommendations to actual conditions possibilities Republic Moldova (RM) is required. Material methods. All guidelines diagnosis treatment GTS disorders were found in PubMed database. articles containing keywords „Tourette diagnosis“, treatment“, „tic diagnosis“ or treatment“ published after 2021 selected. availability RM medications recommended by international verified on site Medicines Medical Devices Agency RM. final text includes synthesis recommendations, adapted Results. tics needs only clinical observation, usually investigations are indicated. It extremely important identify patients whose do need treatment, just monitoring informing about their nature. There three main methods directed against tics: behavioural therapy, pharmacotherapy, and, particular cases, neurosurgical approach (deep brain stimulation). first two had been yet. A attention paid management specific comorbidities tics. Conclusions. based recognition manifestations precise anamnesis. Only with all should be informed tics’ nature, causes evolution. therapy could effective patients, while others would more convenient pharmacotherapy combination both. stimulation) reserved severe resistant therapies.

Language: Английский

Glymphatic system dysfunction in pediatric Tourette syndrome: neuroimaging evidence from MRI metrics DOI Creative Commons

Shu‐Zhen Huang,

Liping Lin,

Xiang Gao

et al.

Journal of Psychiatric Research, Journal Year: 2025, Volume and Issue: 184, P. 1 - 7

Published: Feb. 25, 2025

Language: Английский

Citations

0
Deep brain stimulation (DBS) in movement disorders management: exploring therapeutic efficacy, neurobiological mechanisms, and clinical implications DOI Open Access

Abbas F. Abdul Hussein,

Wafa Mohammad Imran,

Ibrahim Serag

et al.

Annals of Medicine and Surgery, Journal Year: 2025, Volume and Issue: 87(4), P. 2163 - 2179

Published: Feb. 27, 2025

Introduction: Deep brain stimulation (DBS) has emerged as a promising therapeutic approach, offering targeted neuromodulation for movement disorders refractory to medical management or stereotactic surgery. However, assessing its benefits against potential risks is essential. This meta-analysis aims evaluate the efficacy and safety of DBS in disorders, shedding light on role an alternative option. Methods: A comprehensive search databases after systemic review yielded studies published English from 2000 present. Data selection, screening, extraction, risk bias assessment were performed meticulously. Statistical analysis was conducted using RevMan 2.0, with significant heterogeneity addressed through appropriate methods. Results: Our included 40 Unified Parkinson’s Disease Rating Scale Part III, revealing improvement motor symptoms (mean difference [MD]: −18.05, 95% confidence interval [CI] [−20.17, −15.93], P < 0.00001). Hoehn Yahr Stage demonstrated reduction disease severity (MD: −0.58, CI [−1.05, −0.12], = 0.01). Tremor −8.22, [−12.30, −4.15], 0.0001), overall tremor −2.68, [−4.59, −0.77], 0.006), gait velocity 0.13, [0.08, 0.18], 0.00001), Yale Global Tic Severity score −9.75, [−14.55, −4.96], 0.0001) also showed improvements DBS. Conclusion: demonstrates improving symptoms, severity, tremor, gait, tic disorders. further research needed elucidate long-term outcomes.

Language: Английский

Citations

0
WWC1 mutation drives dopamine dysregulation and synaptic imbalance in Tourette’s syndrome DOI Creative Commons
Junkai Lv, Shaoyan Liang, Pengwei Qin

et al.

Science Advances, Journal Year: 2025, Volume and Issue: 11(13)

Published: March 28, 2025

Tourette’s syndrome (TS) is a major neurodevelopmental disorder characterized by childhood-onset motor and vocal tics. A W88C mutation in WWC1 gene notable risk factor for TS, but the underlying molecular mechanisms remain unclear due to lack of suitable animal models. Here, we generate mutant mouse line with human (W88C Mut mice), which exhibits behavioral deficits similar those observed patients including repetitive behaviors sensorimotor gating abnormalities. The leads degradation kidney brain (KIBRA) protein via proteasomal pathway, evokes dopamine release dorsal striatum, disrupts synaptic function through dysregulation Hippo pathway. Neuron-specific overexpression wild-type rescues phenotypes mice. Together, this study not only provides valuable model studying TS also offers fresh insights into abnormalities TS.

Language: Английский

Citations

0
Mechanistic insights and therapeutic approaches in tic disorders: The distinctive role of ethnomedicine and modern medical interventions DOI
Mingyue Zhang, Yinghui Zhang, Yan Chen

et al.

Neuroscience & Biobehavioral Reviews, Journal Year: 2025, Volume and Issue: unknown, P. 106130 - 106130

Published: March 1, 2025

Language: Английский

Citations

0
Progress in research on nutrition, neuroinflammation and dopaminergic alterations in Tic disorders DOI Creative Commons
Bai Lu, Mei Jin,

Qi Zhang

et al.

Frontiers in Pediatrics, Journal Year: 2025, Volume and Issue: 13

Published: May 20, 2025

Tic disorders (TD) represent a prevalent neurodevelopmental condition in children, characterised by involuntary, sudden motor or vocal tics. Dysfunction of the dopamine system plays pivotal role pathogenesis TD. Recent findings indicate that deep brain stimulation, modulating striatal release, substantially alleviates tic symptoms. Neuroimaging studies have shown increased transporter binding and decreased serotonin levels patients with The presence anti-dopamine D2 receptor autoantibodies, which correlate disease severity, suggests immune involvement onset Nutritional factors influence dopaminergic system's functionality affecting neurotransmitter synthesis metabolism, gut microbiota contributing to neuroinflammation. Clinical demonstrated interventions combining probiotics fructooligosaccharides can help regulate whereas dietary patterns such as ketogenic, Mediterranean Mediterranean-DASH intervention for neurodegenerative delay diets exhibit anti-inflammatory neuroprotective effects. risk TD offspring is significantly associated maternal autoimmune diseases inflammatory states, metabolic syndrome further via AT1 autoantibodies. intervention-based treatment strategies present promising directions management, warranting investigation into nutrition–immune–neurotransmitter network, development personalised nutritional plans validation their clinical efficacy through large-scale randomised controlled trials. This review summarises alterations TD, regulatory effects on levels, interactions between neuroinflammation based interventions, laying theoretical foundation understanding advancing novel therapeutic approaches.

Language: Английский

Citations

0
Efficacy of cognitive-behavioral therapy combined with habit reversal training on anxiety disorders in children with Tourette’s syndrome DOI Open Access
Yanzhen Wang, Xi Zhang, Xinmin Han

et al.

World Journal of Psychiatry, Journal Year: 2024, Volume and Issue: 14(7), P. 999 - 1008

Published: July 11, 2024

Cognitive-behavioral therapy (CBT) and habit reversal training (HRT) have shown application potential in addressing tic symptoms comorbid psychiatric conditions. Despite their theoretical potential, empirical evidence on combined efficacy remains limited.

Language: Английский

Citations

2
Ethics of deep brain stimulation for neuropsychiatric disorders DOI

Serhat Aydin,

Kwadwo Darko,

Donald Detchou

et al.

Neurosurgical Review, Journal Year: 2024, Volume and Issue: 47(1)

Published: Aug. 26, 2024

Language: Английский

Citations

2
Pivotal Role of Slitrk1 in Adult Striatal Cholinergic Neurons in Mice: Implication in Tourette Syndrome DOI Open Access

Jung‐Chieh Du,

Man‐Hsin Chang,

Chen‐Jiun Yeh

et al.

Annals of Neurology, Journal Year: 2023, Volume and Issue: 95(1), P. 174 - 189

Published: Sept. 30, 2023

The SLIT and NTRK-like 1 (SLITRK1) gene mutation striatal cholinergic interneurons (ChIs) loss are associated with Tourette syndrome (TS). ChIs comprise only to 2% of neurons but project widely throughout the stratum impact various neurotransmission, including TS-related dopaminergic transmission. Here, we link Slitrk1, ChI function, transmission their associations TS-like tic behaviors.Slitrk1-KD mice were induced by bilaterally injecting Slitrk1 siRNA into dorsal striatum. Control received scrambled injection. Their behaviors, prepulse inhibition, sensory-motor function dopamine-related behaviors compared. We also compared dopamine ACh levels in microdialysates, Slitrk protein transporter levels, numbers Slitrk-positive activated striatum between two mouse groups, electrophysiological properties Slitrk-negative ChIs.Slitrk1-KD exhibit haloperidol-sensitive stereotypic impaired delayed sensorimotor response control group. These characteristics correlate lower fewer Slitrk1-containing ChIs, Slitrk1-KD mice. Based on properties, Slitrk1-negative less excitable than Slitrk1-positive ChIs. have evoked acetylcholine higher tonic downregulated transporters striatum, increased apomorphine-induced climbing methamphetamine-induced hyperlocomotion controls.Slitrk1 is pivotal maintaining activity subsequent for normal motor functioning. Furthermore, conditional may serve as a translational modality aspects TS phenomenology. ANN NEUROL 2023.

Language: Английский

Citations

4
Microlesion Effect Induced by Electrode Implantation in the Posteroventral Globus Pallidus Interna for Severe Dystonic Tics DOI Creative Commons
Galih Indra Permana, Takashi Morishita, Hideaki Tanaka

et al.

Tremor and Other Hyperkinetic Movements, Journal Year: 2024, Volume and Issue: 14(1)

Published: Jan. 1, 2024

Background: Tourette syndrome (TS) is a neurologic condition characterized by motor and phonic tics.Dystonic tics, including blepharospasm, are considered atypical or unusual in severe TS. Case Report:We report case of TS with facial dystonic tics resembling blepharospasm which the microlesion effect sustained therapeutic was observed bilateral globus pallidus interna (GPi) deep brain stimulation (DBS).Discussion: Bilateral GPi DBS can be beneficial for blepharospasm-like symptoms TS.The improvements seen explained induced lead placement GPi.

Language: Английский

Citations

1
Resolution of tonic concentrations of highly similar neurotransmitters using voltammetry and deep learning DOI Creative Commons
Abhinav Goyal, Jason Yuen, Stephen N. Sinicrope

et al.

Molecular Psychiatry, Journal Year: 2024, Volume and Issue: 29(10), P. 3076 - 3085

Published: April 25, 2024

With advances in our understanding regarding the neurochemical underpinnings of neurological and psychiatric diseases, there is an increased demand for advanced computational methods analysis. Despite having a variety techniques measuring tonic extracellular concentrations neurotransmitters, including voltammetry, enzyme-based sensors, amperometry, vivo microdialysis, currently no means to resolve structurally similar neurotransmitters from mixtures environment with high spatiotemporal resolution limited tissue damage. Since research clinical investigations involve brain regions containing electrochemically monoamines, such as dopamine norepinephrine, developing model respective contributions these vital importance. Here we have developed deep learning network, DiscrimNet, convolutional autoencoder capable accurately predicting individual dopamine, serotonin both vitro anesthetized rats, measured using voltammetry. The architecture DiscrimNet described, its ability predict unseen shown vastly outperform shallow algorithms previously used neurotransmitter discrimination. generalize well data captured electrodes during training, eliminating need retrain each new electrode. also expected changes after cocaine oxycodone administration rats vivo. therefore offers exciting method real-time voltammetric signals into component neurotransmitters.

Language: Английский

Citations

1