The SDS2 study (SmartFlat for Dysexecutive Syndrome Stratification - a prospective study quantifying cognitive and behavioral executive dysfunction in patients with acquired brain lesions): statistical analysis plan DOI Creative Commons

Rémy Chapelle,

Flavie Bompaire, Ioannis Bargiotas

et al.

Research Square (Research Square), Journal Year: 2023, Volume and Issue: unknown

Published: Dec. 29, 2023

Abstract Background: Evaluating executive dysfunction in brain-damaged patients remains a significant challenge neurology. Current standard neuropsychological tests, although internally valid, often lack ecological validity. The SDS2 study aims to address this limitation and improve the understanding of by collecting multi-modal data including results from semi-ecological tests. These tests are designed be more reflective real-world challenges faced individuals with dysfunction. Methods: relies on longitudinal, non-randomized design, focusing Arc de Triomphe Construction Test as primary outcome. Various statistical methods, Receiver Operating Characteristic curves, logistic regression models, intraclass correlation coefficients, will used assess performance validity test. Missing handled using multiple imputation techniques. Secondary, subgroup, exploratory analyses focus various aspects collected dataset. Discussion: study's comprehensive framework contribute refining proposed use established methods originating fields state-of-the-art machine learning algorithms seems particularly suited for complex heterogeneous involved. also represent valuable opportunity develop new analysis methods. Trial registration: ClinicalTrials.gov Identifier: NCT05017051. IDRCB: 2021-A00087-34.

Language: Английский

Structural brain networks correlating with poststroke cognition DOI Creative Commons
Sonia Brownsett, Leeanne M. Carey, David A. Copland

et al.

Human Brain Mapping, Journal Year: 2024, Volume and Issue: 45(5)

Published: March 23, 2024

Abstract Cognitive deficits are a common and debilitating consequence of stroke, yet our understanding the structural neurobiological biomarkers predicting recovery cognition after stroke remains limited. In this longitudinal observational study, we set out to investigate effect both focal lesions connectivity on poststroke cognition. Sixty‐two patients with underwent advanced brain imaging cognitive assessment, utilizing Montreal Assessment (MoCA) Mini‐Mental State Examination (MMSE), at 3‐month 12‐month poststroke. We first evaluated relationship between 3 months using voxel‐based lesion‐symptom mapping. Next, novel correlational tractography approach, multi‐shell diffusion‐weighted magnetic resonance (MRI) data collected time points, was used evaluate white matter connectome cross‐sectionally months, longitudinally (12 minus months). Lesion‐symptom mapping did not yield significant findings. turn, analyses revealed positive associations MoCA MMSE scores bilateral cingulum corpus callosum, stage, longitudinally. These results demonstrate that rather than neural structures, consistent underpins performance two frequently screening tools, MMSE, in people stroke. This finding should encourage clinicians researchers only suspect decline when affect these tracts, but also refine their investigation approaches differentially diagnosing pathology associated decline, regardless aetiology.

Language: Английский

Citations

6
A diffusion MRI tractography atlas for concurrent white matter mapping across Eastern and Western populations DOI Creative Commons
Yijie Li, Wei Zhang, Ye Wu

et al.

Scientific Data, Journal Year: 2024, Volume and Issue: 11(1)

Published: July 17, 2024

The study of brain differences across Eastern and Western populations provides vital insights for understanding potential cultural genetic influences on cognition mental health. Diffusion MRI (dMRI) tractography is an important tool in assessing white matter (WM) connectivity tissue microstructure different populations. However, a comprehensive investigation into WM fiber tracts between challenged due to the lack cross-population atlas large site-specific variability dMRI data. This presents atlas, namely East-West Atlas, concurrent mapping creates large, harmonized dataset (n=306) based Human Connectome Project Chinese Project. curated as well subject-specific data including data, whole parcellated their diffusion measures, are publicly released. resource valuable addition facilitating exploration commonalities diverse backgrounds.

Language: Английский

Citations

6
Poststroke Ipsilesional Motor Performance: Microstructural Biomarkers and Their Associations With Executive Function DOI
Youngkook Kim, So Yeon Jun, Jeehae Oh

et al.

Neurorehabilitation and neural repair, Journal Year: 2025, Volume and Issue: unknown

Published: Jan. 2, 2025

Unilateral hemispheric stroke can impair the ipsilesional motor performance, which is crucial for attaining optimal functional outcomes poststroke. However, specific brain structures contributing to performance impairment remain unclear.

Language: Английский

Citations

0
Sleep as a Contributing Factor to Brain Development and Mental Health DOI
Rebecca Cooper

Journal of Adolescent Health, Journal Year: 2025, Volume and Issue: 76(2), P. 181 - 182

Published: Jan. 14, 2025

Language: Английский

Citations

0
Reduced white matter integrity and disrupted brain network in children with type 2 and 3 spinal muscular atrophy DOI Creative Commons

Huirong Nie,

S. Lan, Huan Wang

et al.

Journal of Neurodevelopmental Disorders, Journal Year: 2025, Volume and Issue: 17(1)

Published: Jan. 24, 2025

Language: Английский

Citations

0
Executive functions in adolescence: A longitudinal study comparing evaluations before and after the COVID-19 pandemic DOI
Guadalupe Nathzidy Rivera‐Urbina,

María Fernanda Orozco-Roldán,

Andrés Molero‐Chamizo

et al.

Social Neuroscience, Journal Year: 2025, Volume and Issue: unknown, P. 1 - 9

Published: Jan. 31, 2025

The change in the educational model derived from COVID-19 pandemic might have an impact on cognitive development, particularly Executive Functions (EFs). aim of this study was to explore performance adolescents at two time points (12 and 14 years age), before after restrictions. We also analyzed possible sex differences results. evaluated EFs using Neuropsychological Battery Frontal Lobes (BANFE-2), which includes four indices corresponding specific functions associated prefrontal areas: Orbitofrontal Cortex (OC index -OCI-), Anterior Prefrontal (APCI), Dorsolateral (DCI), cortex as global (EFI). ANOVA conducted compare evaluations revealed no significant pre-post-pandemic any BANFE-2 index, except for OCI, post-pandemic impaired boys (pre post mean score = 96.61 vs. 66.53), but not girls 93.55 95.0). Our findings are thus compatible with idea a different vulnerability between sexes, they reveal may been affected during pandemic.

Language: Английский

Citations

0
Effects of postural loading during static posture holding on concurrent executive function task performance DOI
Yihun Jeong, Hae-Seok Jeong, Doo Won Han

et al.

Applied Ergonomics, Journal Year: 2025, Volume and Issue: 126, P. 104501 - 104501

Published: March 12, 2025

Language: Английский

Citations

0
Visual–Motor Functions and Associated Cognitive Outcomes in Pediatric Cancer Survivors DOI Creative Commons
Alena Deviaterikova

Medical Sciences, Journal Year: 2025, Volume and Issue: 13(2), P. 41 - 41

Published: April 5, 2025

Pediatric cancer survivors are at high risk for visual-motor and cognitive deficits that persist throughout life. These domains related to academic performance. The current study examined (i) whether both visuomotor functions (ii) alone mediate the relationship between age functions. In total, there were 210 participants (7-17 years): 70 posterior fossa tumors (Mage = 12.1 ± 3.2 years, 44% female) acute lymphoblastic leukemia 12.3 3.4 45% 12.2 3.3 41% healthy controls. Visual motor integration, coordination visual perception assessed using Beery VMI test. Working memory, attention planning CANTAB. Impaired function is significantly more pronounced than impairment in groups of (effect size from 25 30% 5 7% functions). A multiple regression model revealed significant predictors (in ALL group β -0.490, t -4.88, p 0.000) working memory PFT 0.264, 2.72, 0.008; 0.215, 2.24, 0.028). children who have experienced cranial fossa, dysfunction impairment. addition, an association disorders memory. findings can be used develop specific rehabilitation protocols.

Language: Английский

Citations

0
Executive Function Response to Moderate-to-High-Intensity Rope Skipping in Overweight Adolescents Aged 12–14: A Preliminary Study DOI Creative Commons
Qian Yu, Xiaodong Wang, Lin Zhang

et al.

Journal of Functional Morphology and Kinesiology, Journal Year: 2025, Volume and Issue: 10(2), P. 152 - 152

Published: April 29, 2025

Background: Previous studies have shown that a high body mass index (BMI) is detrimental to executive function (EF) in children and elderly populations but may be improved by physical activity (PA). However, research on adolescents aged 12–14 lacking. This study explores two parts: Part 1: cross-sectional correlation between BMI EF; 2: the effect of an 8-week rope skipping intervention. Methods: Recruit 166 participate EF tasks. Screen select 96 assigned normal weight control group (N-C, n = 23) exercise (N-E, 23), overweight (OV-C, 13), (OV-E, 14), obese (OB-C, 12), (OB-E, 11). Exercise program: moderate-to-high-intensity training. Control Self-directed reading. Data were recorded for Results: 1, exhibit negative linear correlation. 2, reaction time tasks N-E, OV-E OB-E decreased about 9, 14, 13% (p < 0.05), respectively, while average 10% 11% suggesting potential reduction improvement EF, which means intervention significantly performance. Conclusions: Among 12–14, individuals weaker compared with individuals. An program can improve different BMIs, greater

Language: Английский

Citations

0
Dynamics of White Matter Architecture in Lexical Production among Middle-Aged Adults DOI Creative Commons
Clément Guichet, Élise Roger, Arnaud Attyé

et al.

bioRxiv (Cold Spring Harbor Laboratory), Journal Year: 2024, Volume and Issue: unknown

Published: Feb. 9, 2024

Abstract This study aimed to elucidate the white matter changes associated with lexical production (LP) difficulties that typically emerge in middle age, resulting increased naming latencies. To delay onset of LP decline, middle-aged adults may rely on domain-general (DG) and language-specific (LS) compensatory mechanisms as proposed by LARA model (Lexical Access Retrieval Aging). However, our knowledge supporting these remains incomplete. Based a sample 155 from CAMCAN cohort, we combined dimensionality reduction techniques multivariate statistical methods jointly examine relationships between diffusion-weighted imaging LP-related neuropsychological data. Our findings (i) show midlife constitutes pivotal period marked discontinuity brain structure within distributed networks dorsal, ventral, anterior cortico-subcortical pathways, (ii) reveal this signals neurocognitive transition around age 53-54, marking decline. Indeed, results propose initially adopt “semantic strategy” compensate for initial challenges. Still, strategy be compromised when late (age 55-60) lose ability exert cognitive control over semantic representations (i.e., reduced control). In summary, advances comprehension underpin profile age. Specifically, underscore importance considering interplay DG LS processes studying trajectory performance healthy aging. Furthermore, offer valuable insights into identifying predictive biomarkers related dynamics observed midlife, which can help understand language-related neurodegenerative pathologies. Highlights Midlife characterized structure. Early 45-55) facilitate access sustain performances. Late gradually representations,

Language: Английский

Citations

1