The neurobiology of sentence production: A narrative review and meta-analysis

Brain and Language, Journal Year: 2025, Volume and Issue: 264, P. 105549 - 105549

Published: Feb. 20, 2025

Although there is a sizeable body of literature on sentence comprehension and processing both in healthy disordered language users, the production remains much more sparse. Linguistic computational descriptions expressive syntactic deficits aphasia are especially rare. In addition, neuroimaging (psycho) linguistic literatures operate largely separately. this paper, I will first lay out theoretical land with regard to psycholinguistic models production. then provide brief narrative overview large-scale meta-analysis as it pertains computation, followed by an attempt integrate findings from functional clinical neuroimaging. Finally, surrounding propose path forward close some existing gaps.

Language: Английский

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Distinct neural correlates of morphosyntactic and thematic comprehension processes in aphasia

Brain Communications, Journal Year: 2025, Volume and Issue: 7(2)

Published: Jan. 1, 2025

Abstract Functional neuroimaging studies in neurotypical subjects correlate sentence comprehension to a left fronto-temporo-parietal network. Recent voxel-based lesion-symptom mapping (VLSM) of aphasia confirm the link between and posterior region including angular gyrus, supra-marginal gyrus postero-superior division temporal lobe but support pre-frontal involvement inconsistently. However, these focus on thematic role assignment without considering morphosyntactic processes. Hence, available VLSM evidence could provide partial view neurofunctional substrate comprehension. In present study, both processes were evaluated systematically same types each participant, more detailed picture Participants (33 patients with post-stroke 90 healthy controls) completed sentence–picture matching task which active passive, declarative reversible sentences paired morphosyntactic, lexical-semantic alternatives. Phonological short-term memory tasks also administered. Aphasic participants selected from an initial pool 70 because they scored below norm foils (n = 18) or morphological 15), within foils. The correlates starkly distinguishable. Pre-frontal areas inferior middle frontal involved directly processing local features only indirectly When damaged, errors always co-occurred errors, probably damage disrupts grammatical roles ultimately that roles. Morphosyntactic not influenced by word order canonicity. contrast, selective reversals linked parietal significantly order, occurring passive than sentences. An area was critical for non-canonical order. comprehension, regions are (at least simple sentences). Temporal Postero-superior retrieving verb argument structure. Parietal assigning morphosyntactically analysed constituents appropriate role, thus serving crucial function re-analysis. Each plays prevailing exclusive processes, interacting other network possibly providing language-specific domain-general resources needed at various stages

Language: Английский

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Construct Validation of the Verb Naming Test for Aphasia

Journal of Speech Language and Hearing Research, Journal Year: 2025, Volume and Issue: unknown, P. 1 - 18

Published: March 31, 2025

Purpose: Although there is widespread agreement pertaining to the cognitive processes underlying spoken word production, more generally in aphasia, multiple competing accounts exist regarding involved for verb specifically. Some have speculated that suboptimal control of certain item properties (e.g., imageability) may be partially responsible conflicting reports literature, yet remains a dearth research on psychometric validation production tests aphasia. The purpose present study was investigate constructs Verb Naming Test (VNT), relatively commonly used test, by expanding upon an response theory (IRT) modeling framework we previously described. Method: Using archival data set 107 individuals with specified series IRT models whether covariates (argument structure, imageability), person (aphasia subtype, severity), and their interactions were predictive VNT patterns. Results: Across all models, most strongly associated lexical-semantic processing (imageability, aphasia severity) significant predictors. In contrast, morphosyntactic subtype) minimally predictive. Conclusions: patterns appear primarily explained representing processing. particular, identified important role imageability, covariate not controlled VNT's design, which both aligns body prior further illustrates challenge differentiating from lexical semantic during production. Supplemental Material: https://doi.org/10.23641/asha.28664669

Language: Английский

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Common and distinct patterns underlying different linguistic tasks: multivariate disconnectome symptom mapping in poststroke patients

Cerebral Cortex, Journal Year: 2024, Volume and Issue: unknown

Published: Jan. 23, 2024

Abstract Numerous studies have been devoted to neural mechanisms of a variety linguistic tasks (e.g. speech comprehension and production). To date, however, whether how the patterns underlying different are similar or differ remains elusive. In this study, we compared 3 mainly concerning production. address this, multivariate regression approaches with lesion/disconnection symptom mapping were applied data from 216 stroke patients damage left hemisphere. The results showed that could predict both poststroke scores production tasks; these exhibited shared regions on temporal pole hemisphere as well unique contributing prediction for each domain. Lower in associated lesions/abnormalities superior gyrus middle gyrus, while lower inferior parietal lobe frontal lobe. These suggested an important role ventral dorsal stream pathways (i.e. supporting dual model) highlighted applicability novel disconnectome-based cognitive neuroscience research.

Language: Английский

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Clinical dimensions along the non-fluent variant primary progressive aphasia spectrum

Brain, Journal Year: 2023, Volume and Issue: 147(4), P. 1511 - 1525

Published: Nov. 21, 2023

Abstract It is debated whether primary progressive apraxia of speech (PPAOS) and agrammatic aphasia (PAA) belong to the same clinical spectrum, traditionally termed non-fluent/agrammatic variant (nfvPPA), or exist as two completely distinct syndromic entities with specific pathologic/prognostic correlates. We analysed speech, language disease severity features in a comprehensive cohort patients motor impairment and/or agrammatism ascertain evidence naturally occurring, clinically meaningful non-overlapping (e.g. PPAOS PAA) our data. also assessed if data-driven latent dimensions aetiologic/prognostic value could be identified. included 98 participants, 43 whom had an autopsy-confirmed neuropathological diagnosis. Speech pathologists indicative dysarthria (AOS). Quantitative expressive/receptive measures were obtained compared healthy controls. Baseline longitudinal was evaluated using Clinical Dementia Rating Sum Boxes (CDR-SB). investigated data’s clustering tendency cluster stability form robust symptom clusters employed principal component analysis extract (LCD). The CDR-SB change estimated linear mixed-effects models. Of participants this study, 93 conformed previously reported profiles (75 AOS agrammatism, 12 six PAA). remaining five characterized by non-fluent executive dysfunction without frank agrammatism. No baseline differentiated between frontotemporal lobar degeneration subgroups. Hopkins statistic demonstrated low entire sample (0.45 values near 0.5 indicating random data). Cluster analyses showed that only subgroups (differing overall severity) Three components accounted for 71% variance [(i) severity-agrammatism; (ii) prominent AOS; (iii) dysarthria]. None these LCDs allowed accurate prediction neuropathology. severity-agrammatism independent predictor faster increase all participants. Higher severity, reduced words per minute expressive receptive at independently predicted accelerated progression. Our findings indicate PAA, rather than entities, constitute continuum. In cohort, splitting nfvPPA spectrum into separate phenotypes did not improve clinical-pathological correlations, stressing need new biological markers consensus regarding updated terminology classification.

Language: Английский

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Was Broca wrong?

Brain, Journal Year: 2024, Volume and Issue: 147(2), P. 325 - 326

Published: Feb. 1, 2024

Language: Английский

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Pure-tone audiometry and dichotic listening in primary progressive aphasia and Alzheimer’s disease

medRxiv (Cold Spring Harbor Laboratory), Journal Year: 2024, Volume and Issue: unknown

Published: March 15, 2024

Abstract Hearing is multifaceted and the relative contributions of peripheral central hearing loss are rarely considered together in context dementia. Here, we assessed (as measured with pure-tone audiometry) dichotic listening) 19 patients typical amnestic Alzheimer’s disease (tAD), 10 logopenic variant primary progressive aphasia (lvPPA), 11 nonfluent/agrammatic PPA (nfvPPA), 15 semantic (svPPA), 28 healthy age-matched individuals. Participants also underwent neuropsychological assessment magnetic resonance image scanning, allowing us to use voxel-based morphometry assess associations between scores grey matter volume. Dichotic listening was impaired all patient groups controls. In combined (but not control) cohort, were significantly correlated measures global cognitive functioning speech-based tasks. Pure-tone audiometry elevated any group control group, no significant correlations observed task performance either or cohorts. Neuroanatomically, associated volume a bilateral fronto-temporo-parietal network over but correlates identified for audiometry. Our findings highlight importance speech parsing mechanisms beyond elementary sound detection driving test performance, underline assessing alongside people dementia, further delineate complex auditory profiles neurodegenerative dementias.

Language: Английский

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Verbal short term memory contribution to sentence comprehension decreases with increasing syntactic complexity in people with aphasia

NeuroImage, Journal Year: 2024, Volume and Issue: 297, P. 120730 - 120730

Published: July 14, 2024

Sentence comprehension requires the integration of linguistic units presented in a temporal sequence based on non-linear underlying syntactic structure. While it is uncontroversial that storage mandatory for this process, there are opposing views regarding relevance general short-term-/working-memory capacities (STM/WM) versus language specific resources. Here we report results from 43 participants with an acquired brain lesion extended left hemispheric network and resulting deficits, who performed sentence-to-picture matching task experimental assessing phonological short-term memory. The sentence systematically varied complexity (embedding depth argument order) while lengths, number propositions plausibility were kept constant. Clinical data including digit-/ block-spans size site additionally used analyses. Correlational analyses confirm performance STM/WM-tasks (experimental digit-span) only two relevant predictors correct sentence-picture-matching, reaction times depended age size. Notably increasing reduced correlational strength speaking additional recruitment resources independent more verbal STM/WM capacities, when resolving complex complementary lesion-behaviour analysis yielded different volumes correlating either sentence-task or STM-task. Factoring out STM measures lesions anterior lobe correlated larger decrease accuracy complexity. We conclude overall depends capacity, increases tax another cognitive resource.

Language: Английский

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EXPRESS: Pure-tone audiometry and dichotic listening in primary progressive aphasia and Alzheimer's disease

Quarterly Journal of Experimental Psychology, Journal Year: 2024, Volume and Issue: unknown

Published: Sept. 19, 2024

Hearing is multifaceted, and the relative contributions of peripheral central hearing loss are rarely considered together in context dementia. Here, we assessed (as measured with pure-tone audiometry) dichotic listening) 19 patients typical amnestic Alzheimer’s disease (tAD), 10 logopenic variant primary progressive aphasia (lvPPA), 11 nonfluent/agrammatic PPA (nfvPPA), 15 semantic (svPPA), 28 healthy age-matched individuals. Participants also underwent neuropsychological assessment magnetic resonance image scanning, allowing us to use voxel-based morphometry assess associations between scores grey matter volume. Dichotic listening was impaired all patient groups controls. In combined (but not control) cohort, were significantly correlated measures global cognitive functioning speech-based tasks. Pure-tone audiometry elevated any group control group, no significant correlations observed task performance either or cohorts. Neuroanatomically, associated volume a bilateral fronto-temporoparietal network over but correlates identified for audiometry. Our findings highlight importance speech parsing mechanisms beyond elementary sound detection driving test performance, underline assessing alongside people dementia, further delineate complex auditory profiles neurodegenerative dementias.

Language: Английский

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Frontotemporal Dementia

CONTINUUM Lifelong Learning in Neurology, Journal Year: 2024, Volume and Issue: 30(6), P. 1642 - 1672

Published: Dec. 1, 2024

ABSTRACT OBJECTIVE This article discusses frontotemporal dementia (FTD) syndromes using a simplified framework of three core syndromes, including details on their pathology and unique genetic variations. LATEST DEVELOPMENTS FTD includes at least seven major clinical syndromes. The are behavioral variant two forms progressive aphasia, commonly referred to as the nonfluent semantic primary aphasia. Clinical features reflect involvement functional brain networks. Derangements proteins account for nearly all underlying syndromes: transactive response DNA-binding protein 43 (TDP-43) (approximately 50% cases), MAPT (45% FUS (5% cases). presentation imaging provide clues pathology. is more heritable than Alzheimer disease, with variations in C9orf72 , or GRN (which encodes progranulin) occurring 10% cases. ESSENTIAL POINTS described here will clinicians foundation understanding complex heterogeneous set There currently no disease-modifying US Food Drug Administration (FDA)–approved treatments FTD, but trials underway, some targeting presymptomatic variation carriers. Available address deficits behavior language nonpharmacologically through off-label use medications approved other indications. Improvements biomarkers accelerate discovery new pharmacologic treatments.

Language: Английский

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