Journal of Neurophysiology,
Journal Year:
2024,
Volume and Issue:
132(3), P. 953 - 967
Published: Aug. 7, 2024
Subject-specific
computational
models
of
pallidal
deep
brain
stimulation,
in
conjunction
with
quantitative
measures
forearm
rigidity,
were
used
to
examine
the
neural
pathways
mediating
stimulation-induced
changes
rigidity
people
Parkinson’s
disease.
The
model
uniquely
included
internal,
efferent
and
adjacent
basal
ganglia.
results
demonstrate
that
reductions
evoked
by
stimulation
principally
mediated
activation
globus
pallidus
internus
pathways.
bioRxiv (Cold Spring Harbor Laboratory),
Journal Year:
2024,
Volume and Issue:
unknown
Published: June 30, 2024
Abstract
Introduction
Essential
Tremor
(ET)
is
a
common
neurological
disorder
identified
by
involuntary
rhythmic
movements
stemming
from
pathological
synchronization
within
network
that
overlaps
significantly
with
the
normal
motor
circuit.
The
efficacy
of
therapeutic
brain
stimulation
for
ET
impeded
limited
understanding
how
tremor-related
affects
circuits
and
disrupts
sensorimotor
processing.
This
paper
details
changes
in
brain-wide
associated
connects
these
to
oscillatory
dynamics
during
voluntary
movements.
Methods
We
used
high-density
electroencephalography
(EEG,
11
controls,
12
patients),
first
time
patients,
optically
pumped
magnetoencephalography
(OPM,
5
4
patients)
record
activity
upper
limb
reaching.
localized
analysed
sources
synchronize
tremors,
studying
oscillations
regions.
Using
novel
dimensionality
reduction
approach,
we
set
simple,
latent
specific
frequency
characteristics
their
relationship
kinematics
tremor.
Results
Despite
slight
reductions
velocity,
patients
demonstrated
reaching
comparable
controls.
Notably,
key
areas
-
including
supplementary
area,
lateral
prefrontal
cortex,
posterior
parietal
cerebellum
were
synchronized
tremor
frequencies.
Motor
changed
relative
15%
increase
movement
responsive
desynchronization
low
beta
(14-21
Hz)
band
which
inversely
correlated
severity.
Oscillations
theta
bands
predictors
patients’
overall
levels.
Latent
state
analysis
EEG
OPM
data
located
fronto-parietal
premotor/prefrontal
circuits.
High
trials
diminished
post-movement
rebound
frontoparietal
premotor
an
gamma
(30-60
Hz).
predictive
velocity
hold
stability,
suggesting
increased
related
may
reflect
compensatory
mechanism
brain.
Conclusions
study
demonstrates
leads
significant
individual
regions
broader
networks.
Specifically,
suggest
networks
enables
successful
execution
movement,
freeing
neural
resources
otherwise
entrained
at
Our
findings,
reproducible
across
both
recordings,
underline
motor-related
signals
can
predict
subject
level
severity
offer
new
candidate
biomarkers
crucial
developing
advanced
closed-loop
therapies
ET.
Neurodegenerative Disease Management,
Journal Year:
2024,
Volume and Issue:
unknown, P. 1 - 17
Published: Sept. 30, 2024
Deep
brain
stimulation
(DBS)
has
been
established
as
an
effective
neuromodulatory
treatment
for
Parkinson's
disease
(PD)
with
motor
complications
or
refractory
tremor.
Various
DBS
devices
unique
technology
platforms
are
commercially
available
and
deliver
continuous,
open-loop
stimulation.
The
Percept™
family
of
neurostimulators
use
BrainSense™
five
key
features
to
sense
local
field
potentials
while
stimulating,
enabling
integration
physiologic
data
into
the
routine
practice
programming.
newly
approved
rechargeable
RC
implantable
pulse
generator
offers
a
smaller,
thinner
design
reduced
recharge
time
prolonged
interval.
In
this
review,
we
describe
application
potential
sensing-based
programming
in
PD
highlight
future
clinical
implementation
closed-loop
using
generator.
Expert Review of Medical Devices,
Journal Year:
2024,
Volume and Issue:
unknown, P. 1 - 12
Published: Dec. 7, 2024
A
closed-loop
or
feedback-control
system
is
a
process
which
considers
the
system's
output
in
order
to
automatically
adjust
input.
Compared
traditional
open-loop
system,
allows
for
higher
degree
of
accuracy
with
minimal
human
intervention.
Novel
methods
closed
loop
'adaptive'
deep
brain
stimulation
DBS
(aDBS)
are
being
developed.
Brain,
Journal Year:
2024,
Volume and Issue:
147(3), P. 749 - 751
Published: Feb. 12, 2024
This
scientific
commentary
refers
to
‘At
home
adaptive
dual
target
deep
brain
stimulation
in
Parkinson
disease
with
proportional
control’
by
Schmidt
et
al.
(https://doi.org/10.1093/brain/awad429).
Journal of Neurophysiology,
Journal Year:
2024,
Volume and Issue:
132(3), P. 953 - 967
Published: Aug. 7, 2024
Subject-specific
computational
models
of
pallidal
deep
brain
stimulation,
in
conjunction
with
quantitative
measures
forearm
rigidity,
were
used
to
examine
the
neural
pathways
mediating
stimulation-induced
changes
rigidity
people
Parkinson’s
disease.
The
model
uniquely
included
internal,
efferent
and
adjacent
basal
ganglia.
results
demonstrate
that
reductions
evoked
by
stimulation
principally
mediated
activation
globus
pallidus
internus
pathways.
