Network mechanisms in rapid-onset dystonia-parkinsonism DOI Creative Commons
Martin Möller,

Johanna Nieweler,

Vadim V. Nikulin

et al.

bioRxiv (Cold Spring Harbor Laboratory), Journal Year: 2024, Volume and Issue: unknown

Published: Oct. 16, 2024

Abstract Background Rapid-onset dystonia-parkinsonism (RDP) is a rare neurological disorder caused by mutations in the ATP1A3 gene. Symptoms are characterized dystonia-parkinsonism. Recently, experimental studies have shown that pathophysiology of disease based on combined dysfunction cerebellum (CB) and basal ganglia (BG) blocking their interaction can alleviate symptoms. The underlying network mechanisms not been studied so far. Objective Our aim was to characterize neuronal activity BG CB motor cortex ouabain model RDP site-specific infusion ouabain. Methods Rats were chronically infused with either CB, striatum (STR) or at both places simultaneously. Motor behavior scored using published rating systems. Parallel vivo recordings local field potentials (LFP) from M1, deep cerebellar nuclei (DCN) substantia nigra reticulata (SNr) performed. Data compared untreated controls. Results Ouabain into produced severe dystonia associated increased high-frequency gamma oscillations DCNs, which subsequently transmitted M1. Striatal led parkinsonism elevated beta- SNr simultaneous application STRs resulted beta BG, Conclusion We demonstrate symptom-specific be between likely very important for understanding mechanisms.

Language: Английский

Chronic adaptive deep brain stimulation versus conventional stimulation in Parkinson’s disease: a blinded randomized feasibility trial DOI
Carina R. Oehrn, Stephanie Cernera, Lauren H. Hammer

et al.

Nature Medicine, Journal Year: 2024, Volume and Issue: 30(11), P. 3345 - 3356

Published: Aug. 19, 2024

Language: Английский

Citations

44
Synchronization of complex networks with synapse regulated by energy difference DOI
Ying Xie, Xuening Li, Xueqin Wang

et al.

Nonlinear Dynamics, Journal Year: 2025, Volume and Issue: unknown

Published: Jan. 6, 2025

Language: Английский

Citations

2
Subthalamic control of impulsive actions: insights from deep brain stimulation in Parkinson’s disease DOI Creative Commons
Damian M. Herz, Michael J. Frank, Huiling Tan

et al.

Brain, Journal Year: 2024, Volume and Issue: 147(11), P. 3651 - 3664

Published: June 12, 2024

Abstract Control of actions allows adaptive, goal-directed behaviour. The basal ganglia, including the subthalamic nucleus, are thought to play a central role in dynamically controlling through recurrent negative feedback loops with cerebral cortex. Here, we summarize recent translational studies that used deep brain stimulation record neural activity from and apply electrical nucleus people Parkinson’s disease. These have elucidated spatial, spectral temporal features mechanisms underlying controlled delay cortico-subthalamic networks demonstrated their causal effects on behaviour distinct processing windows. While these been conceptualized as control signals for suppressing impulsive response tendencies conflict tasks decision threshold adjustments value-based perceptual decisions, propose common framework linking decision-making, cognition movement. Within this framework, can lead suboptimal choices by reducing time patients take deliberation before committing an action. However, clinical consistently shown occurrence impulse disorders is reduced, not increased, after surgery. This apparent contradiction be reconciled when recognizing multifaceted nature impulsivity, its modulation treatment. renders susceptible making decisions without proper forethought, disentangled related dopamine comprising sensitivity benefits versus costs, reward aversion learning outcomes. Alterations dopamine-mediated underlie development relatively spared reduced dopaminergic medication stimulation. Together, results using experimental tool improved our understanding action human important implications treatment neurological disorders.

Language: Английский

Citations

5
Deep brain stimulation-entrained gamma oscillations in chronic home recordings in Parkinson’s disease DOI Creative Commons

Maria Olaru,

A. G. Hahn,

Maria Shcherbakova

et al.

Brain stimulation, Journal Year: 2025, Volume and Issue: unknown

Published: Feb. 1, 2025

Highlights•Cortical gamma oscillations often entrain with pallidal and subthalamic stimulation•Entraining levodopa-induced diminishes their prodyskinetic effect•Levodopa-induced oscillation peak frequency variance reduces when entrainedAbstractBackgroundIn Parkinson's disease, invasive brain recordings show that dopaminergic medication can induce narrowband rhythms in the motor cortex nucleus, which co-fluctuate dyskinesia scores. Deep stimulation these to a subharmonic frequency. However, incidence of entrainment during chronic therapeutic stimulation, its relationship basal ganglia site, effect on remain unknown.ObjectiveDetermine whether behavioral effects statistical properties are altered entrained deep stimulation.MethodsWe used sensing-enabled stimulator system, attached both (n=15) or (n=5) leads, record 993 hours multisite field potentials, 656 recorded prior initiating stimulation. 13 subjects (20 hemispheres) disease (1/13 female, mean age 59±9 years) streamed data while at home usual antiparkinsonian medication. Recordings occurred least five months after stimulation.ResultsCortical were detected 4/5 hemispheres undergoing 12/15 Entraining either site reduced effects. Cortical had frequency, increased spectral power, higher power than oscillations.ConclusionStimulation-entrained functionally physiologically distinct from occur absence Understanding discrepancies between types may improve programming protocols.

Language: Английский

Citations

0
Closing the Loop in DBS: A Data-driven Approach DOI Creative Commons

Prerana Acharyya,

Karen M. Daley,

Jin Woo Choi

et al.

Parkinsonism & Related Disorders, Journal Year: 2025, Volume and Issue: unknown, P. 107348 - 107348

Published: Feb. 1, 2025

Language: Английский

Citations

0
Beta Burst Characteristics and Coupling within the Sensorimotor Cortical‐Subthalamic Nucleus Circuit Dynamically Relate to Bradykinesia in Parkinson's Disease DOI Creative Commons
Pan Yao, Abhinav Sharma, Bahman Abdi‐Sargezeh

et al.

Movement Disorders, Journal Year: 2025, Volume and Issue: unknown

Published: Feb. 27, 2025

Bursts of exaggerated subthalamic nucleus (STN) beta activity are believed to contribute clinical impairments in Parkinson's disease (PD). No previous studies have explored burst characteristics and coupling across the sensorimotor cortical-STN circuit determined their relationship dynamic measurements bradykinesia. We sought (1) establish cortical STN bursts during naturalistic behaviors, (2) determine predictability from motor recordings, (3) relate features continuous bradykinesia using wearable sensors. analyzed 1046 h wirelessly streamed bilateral recordings 5 PD patients with concurrent were longer than had shorter inter-burst intervals. Long (>200 ms) both structures displayed temporal overlap (>30%), tending lead onset by 8 ms. Worsening was linked increased rates durations, whereas properties opposite effect. Cortical tend precede short delays occurrence relates worsening settings. © 2025 The Author(s). Movement Disorders published Wiley Periodicals LLC on behalf International Parkinson Disorder Society.

Language: Английский

Citations

0
Neurophysiological Treatment Effects of Mesdopetam, Pimavanserin and Amantadine in a Rodent Model of Levodopa‐Induced Dyskinesia DOI Creative Commons
Abdolaziz Ronaghi,

Tiberiu Loredan Stan,

Sebastián A. Barrientos

et al.

European Journal of Neuroscience, Journal Year: 2025, Volume and Issue: 61(5)

Published: March 1, 2025

Levodopa provides effective symptomatic treatment for Parkinson's disease. However, nonmotor symptoms are often insufficiently relieved, and its long-term use is complicated by motor fluctuations dyskinesia. To clarify mechanisms of levodopa-induced dyskinesia pharmacological interventions aimed at reducing dyskinetic symptoms, we have here characterized the neurophysiological activity patterns in sensorimotor cognitive-limbic circuits rats, comparing effects amantadine, pimavanserin, novel prospective antidyskinetic antipsychotic mesdopetam. Parallel recordings local field potentials from 11 cortical subcortical regions revealed suppression narrowband gamma oscillations (NBGs) structures amantadine mesdopetam conjunction with alleviation signs. Concomitant were not directly linked to affected treatments same extent, although treatment-induced reductions functional coupling observed both circuits, parallel. In a broad frequency spectrum (1-200 Hz), displayed greater similarities pimavanserin than amantadine. These findings point reduction NBGs as valuable biomarker characterization provide systems-level mechanistic insights into efficacy mesdopetam, potential additional benefits Parkinson's-related psychosis.

Language: Английский

Citations

0
At-Home Movement State Classification Using Totally Implantable Bidirectional Cortical-Basal Ganglia Neural Interface DOI Creative Commons
Doris D. Wang, R. Ramesh, Hamid Fekri Azgomi

et al.

Research Square (Research Square), Journal Year: 2025, Volume and Issue: unknown

Published: March 12, 2025

Movement decoding from invasive human recordings typically relies on a distributed system employing advanced machine learning algorithms programmed into an external computer for state classification. These brain-computer interfaces are limited to short-term studies in laboratory settings that may not reflect behavior and neural states the real world. The development of implantable devices with sensing capabilities is revolutionizing study treatment brain circuits. However, it unknown whether these can decode natural movement recorded activity or accurately classify real-time using on-board algorithms. Here, totally implanted sensing-enabled neurostimulator perform long-term, at-home motor cortex pallidum four subjects Parkinson's disease, we successfully identified highly sensitive specific personalized signatures gait state, as determined by wearable sensors. Additionally, demonstrated feasibility data generate biomarkers compatible classifier embedded neurostimulator. findings offer pipeline ecologically valid biomarker identification advance therapy across variety diseases.

Language: Английский

Citations

0
Finely Tuned γ Tracks Medication Cycles in Parkinson's Disease: An Ambulatory Brain‐Sense Study DOI Creative Commons
Aaron Colombo,

Elena Bernasconi,

Laura Alva

et al.

Movement Disorders, Journal Year: 2025, Volume and Issue: unknown

Published: March 13, 2025

Abstract Background Novel commercial brain‐sense neurostimulators enable us to contextualize brain activity with symptom and medication states in real‐life ambulatory settings Parkinson's disease (PD). Although various candidate biomarkers have been proposed for adaptive deep stimulation (DBS), a comprehensive comparison of their profiles is lacking. Objectives To systematically compare the neurophysiological dynamics clinical properties three biomarkers—low‐frequency, beta (β), finely tuned γ (FTG) activity. Methods We investigated 14 PD patients implanted Medtronic Percept PC, who underwent up two 4‐week multimodal recording periods on regular stimulation. Subthalamic nucleus local field potentials (LFPs) low‐frequency, β, FTG were recorded. Additionally, objective motor states, physical heart rate using wearables, as well medication‐intake times, sleep‐awake subjective diaries co‐registered. LFP also compared high‐resolution in‐hospital recordings under off / dopaminergic conditions. Results reliably indexed setting at group individual levels, these spectral could be anticipated by recordings. Both low‐frequency correlated wearable‐based dyskinesia scores, whereas diary‐based events only linked FTG. Importantly, indicated ‐medication regardless presence despite potential motion artifacts. The 24‐hour profile revealed large circadian power shifts that may overdrive dynamics. Conclusion Despite limitations low‐temporal resolution recordings, this work provides valuable insights into biomarkers. Specifically, it highlights utility primary reliable indicator DBS. © 2025 Author(s). Movement Disorders published Wiley Periodicals LLC behalf International Parkinson Disorder Society.

Language: Английский

Citations

0
Gamma entrainment induced by deep brain stimulation as a biomarker for motor improvement with neuromodulation DOI Creative Commons
Varvara Mathiopoulou, Jeroen Habets, Lucia K. Feldmann

et al.

Nature Communications, Journal Year: 2025, Volume and Issue: 16(1)

Published: March 26, 2025

Abstract Finely tuned gamma (FTG) oscillations from the subthalamic nucleus (STN) and cortex in Parkinson’s disease (PD) patients undergoing deep brain stimulation (DBS) are often associated with dyskinesia. Recently it was shown that DBS entrains activity at 1:2 of frequency; however, functional role this signal is not yet fully understood. We recorded local field potentials STN 19 chronically implanted PD on dopaminergic medication during DBS, rest, repetitive movements. Here we show high-frequency induced entrainment 15/19 patients. Spontaneous FTG present 8 patients; five these dyskinesia occurred or were enhanced entrained stimulation. Further, there a significant increase power movement comparison to while had faster movements compared those without. These findings argue for relevance stimulation-induced as prokinetic that, necessarily promoting DBS-induced can be promising neurophysiological biomarker identifying optimal amplitude closed-loop DBS.

Language: Английский

Citations

0