Real-time multisite invasive neural recording during downhill skiing in Parkinson’s disease: a case report

Frontiers in Neuroscience, Journal Year: 2025, Volume and Issue: 19

Published: April 14, 2025

Introduction Invasive recording of neural activity provides valuable insights into Parkinson’s disease (PD). Bidirectional sensing devices enable wireless data collection during everyday activities, but signals complex outdoor sports remain unexplored. Methods We recorded from a 57-year-old PD patient using bilateral implanted pulse generators connected to subthalamic nucleus (STN) and motor cortex leads. Recordings were performed in two settings: in-clinic computer-controlled task outdoors downhill skiing. Neural analyzed for power spectral density (PSD) coherence across different frequencies. Results In-clinic recordings demonstrated movement-related cortical STN beta desynchronization with gamma increase. Skiing similarly induced also elicited low-gamma (30–60 Hz) unique finely-tuned (FTG) at 85 Hz the off-medication state, predominantly less affected hemisphere. Tremor-related suppression was observed stopping, prominent 10 associated resting tremor. Conclusion Real-time multisite revealed distinct signatures compared tasks. The findings suggest that self-cued, learned tasks elicit frequency bands highlight differences based on asymmetry medication state.

Language: Английский

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Shared pathway-specific network mechanisms of dopamine and deep brain stimulation for the treatment of Parkinson’s disease

Nature Communications, Journal Year: 2025, Volume and Issue: 16(1)

Published: April 15, 2025

Abstract Deep brain stimulation is a circuit intervention that can modulate distinct neural pathways for the alleviation of neurological symptoms in patients with disorders. In Parkinson’s disease, subthalamic deep clinically mimics effect dopaminergic drug treatment, but shared pathway mechanisms on cortex – basal ganglia networks are unknown. To address this critical knowledge gap, we combined fully invasive multisite recordings undergoing surgery normative MRI-based whole-brain connectomics. Our findings demonstrate dopamine and exert mesoscale effects through modulation local population activity. contrast, at macroscale, its suppression excessive interregional network synchrony associated indirect hyperdirect pathways. results provide better understanding stimulation, laying foundation advanced closed-loop neurostimulation therapies.

Language: Английский

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Neural Networks and Chemical Messengers: Insights into Tobacco Addiction

Brain Topography, Journal Year: 2025, Volume and Issue: 38(4)

Published: May 13, 2025

Language: Английский

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Shared pathway-specific network mechanisms of dopamine and deep brain stimulation for the treatment of Parkinson's disease

bioRxiv (Cold Spring Harbor Laboratory), Journal Year: 2024, Volume and Issue: unknown

Published: April 17, 2024

Deep brain stimulation is a circuit intervention that can modulate distinct neural pathways for the alleviation of neurological symptoms in patients with disorders. In Parkinson's disease, subthalamic deep clinically mimics effect dopaminergic drug treatment, but shared pathway mechanisms on cortex - basal ganglia networks are unknown. To address this critical knowledge gap, we combined fully invasive multisite recordings undergoing surgery normative MRI-based whole-brain connectomics. Our findings demonstrate dopamine and exert mesoscale effects through modulation local population activity. contrast, at macroscale, its suppression excessive interregional network synchrony associated indirect hyperdirect pathways. results provide better understanding stimulation, laying foundation advanced closed-loop neurostimulation therapies.

Language: Английский

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Prediction of pathological subthalamic nucleus beta burst occurrence in Parkinson’s disease

bioRxiv (Cold Spring Harbor Laboratory), Journal Year: 2024, Volume and Issue: unknown

Published: May 9, 2024

Abstract The cortico-basal ganglia network in Parkinson’s disease (PD) is characterized by the emergence of transient episodes exaggerated beta frequency oscillatory synchrony known as bursts. Although it well established that bursts prolonged duration associate closely with motor impairments, mechanisms leading to burst initiation remain poorly understood. Crucially, unclear whether there are features basal activity which reliably predict onset. Current adaptive Deep Brain Stimulation (aDBS) approaches can only reactively deliver stimulation following detection and unable stimulate proactively prevent discovery predictive biomarkers could allow for such proactive stimulation, thereby offering potential improvements therapeutic efficacy. Here, using deep learning, we show timing subthalamic nucleus (STN) be accurately predicted up 60 ms prior Furthermore, highlight a dip amplitude - likely indicative phase reset populations occurring between 80-100 onset biomarker occurrence. These findings demonstrate proof-of-principle feasibility prediction DBS provide insights into initiation.

Language: Английский

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Decoupling of motor cortex to movement in Parkinson’s dyskinesia rescued by sub-anaesthetic ketamine

Brain, Journal Year: 2024, Volume and Issue: unknown

Published: Nov. 25, 2024

Gamma band and single-unit neural activity in primary motor cortex (M1) are involved the control of movement. This is disrupted Parkinson's disease (PD) levodopa-induced dyskinesia (LID), a debilitating consequence dopamine replacement therapy for PD. Physiological features LID include pathological narrowband gamma oscillations, finely tuned (FTG), altered M1 firing activity. Since most studies characterize through visual scoring, little known about relationships between ongoing dyskinetic movements, gamma, neuronal at fast (sub-second) slow (seconds) timescales. Here, we investigate how changes with movement multiple timescales animal models PD LID. Furthermore, sub-anesthetic ketamine has emerged as possible How may reduce not fully understood. Consequently, affects relationship To these questions, local-field from >3000 neurons was acquired using standard model PD/LID (n = 10 male rats). Data sham animals following levodopa (L-DOPA; 12 mg/kg, i.p.) (20 administration. Movement assessed traditional abnormal involuntary movements (AIMs) scores head-mounted inertial sensors sampled 200 Hz. While correlations movement, were high all during conditions, decreased considerably L-DOPA suggests that can become functionally decoupled Interestingly, this effect observed both depleted non-depleted hemispheres. Ketamine FTG, LID, moderately increased to Ketamine, however, did enhance correlation gamma-band Finally, exerted selective on interactions ensemble animals. Specifically, analysis cell-pair firing-rate showed induced distinct state by reorganizing pattern interactions. These findings provide insight into role play healthy Results suggest does directly trigger specific but, instead, dysregulated permit aberrant spontaneously emerge downstream circuits. data further support anti-dyskinetic properties acts disrupting dyskinesia.

Language: Английский

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Beta burst characteristics and coupling within the sensorimotor cortical-subthalamic nucleus circuit in Parkinson's disease

bioRxiv (Cold Spring Harbor Laboratory), Journal Year: 2024, Volume and Issue: unknown

Published: Nov. 21, 2024

Background: Bursts of exaggerated subthalamic nucleus (STN) beta activity contribute to clinical impairments in Parkinson's disease (PD). Few studies have explored the characteristics and coupling bursts across sensorimotor cortical-STN circuit. Objective: We sought (1) establish cortical STN during naturalistic behaviours, (2) determine predictability from motor recordings. Methods: analysed 1,478 hours wirelessly streamed bilateral recordings 5 PD patients. Results: were longer than had shorter inter-burst intervals. Long (>200ms) both structures displayed temporal overlap (>30%), with an estimated cortico-STN conduction delay 8ms. Furthermore, approximately 27% all preceded by a burst. Conclusion: Cortical tend precede bursts, short delays. However, subcortical mechanisms are also likely burst initiation propagation.

Language: Английский

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Network mechanisms in rapid-onset dystonia-parkinsonism

bioRxiv (Cold Spring Harbor Laboratory), Journal Year: 2024, Volume and Issue: unknown

Published: Oct. 16, 2024

Abstract Background Rapid-onset dystonia-parkinsonism (RDP) is a rare neurological disorder caused by mutations in the ATP1A3 gene. Symptoms are characterized dystonia-parkinsonism. Recently, experimental studies have shown that pathophysiology of disease based on combined dysfunction cerebellum (CB) and basal ganglia (BG) blocking their interaction can alleviate symptoms. The underlying network mechanisms not been studied so far. Objective Our aim was to characterize neuronal activity BG CB motor cortex ouabain model RDP site-specific infusion ouabain. Methods Rats were chronically infused with either CB, striatum (STR) or at both places simultaneously. Motor behavior scored using published rating systems. Parallel vivo recordings local field potentials (LFP) from M1, deep cerebellar nuclei (DCN) substantia nigra reticulata (SNr) performed. Data compared untreated controls. Results Ouabain into produced severe dystonia associated increased high-frequency gamma oscillations DCNs, which subsequently transmitted M1. Striatal led parkinsonism elevated beta- SNr simultaneous application STRs resulted beta BG, Conclusion We demonstrate symptom-specific be between likely very important for understanding mechanisms.

Language: Английский

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