Association between calculated remnant cholesterol levels and incident risks of Alzheimer’s disease among elderly patients with type 2 diabetes: a real-world study DOI Creative Commons

Hong Jia,

Liuyu Zhang,

Huijuan Liao

et al.

Frontiers in Endocrinology, Journal Year: 2024, Volume and Issue: 15

Published: Nov. 29, 2024

Alzheimer's disease (AD) is a leading cause of dementia, with rising global burden. Remnant cholesterol (RC), component triglyceride-rich lipoproteins, has been implicated in cardiovascular diseases and metabolic disorders, but its role AD remains unclear. This study investigated the association between RC levels risk among elderly patients type 2 diabetes (T2D) real-world clinical setting. We conducted retrospective cohort using electronic medical records from Gongli Hospital Shanghai Pudong New Area, covering period 2013 to 2023. The included 15,364 aged 65-80 years T2D. were calculated equation. primary outcome was diagnosis AD, validated by neurologists ICD-10-CM code G30. Cox proportional hazards models employed estimate hazard ratios (HRs) for across quartiles levels, adjusting potential confounders. Over mean follow-up 3.69 ± 1.33 years, 312 new cases identified. A U-shaped relationship observed risk, lowest associated 0.58-0.64 mmol/L. Both lower (<0.52 mmol/L) higher (≥0.77 linked increased risk. Compared reference group (Q2: 0.52-0.64 mmol/L), adjusted HRs (95% CI) highest 1.891 (1.368-2.613) (1.363-2.622), respectively. Each 1 mmol/L increase 3.47-fold (HR=4.474, 95% CI 2.330-8.592). may serve as predictive biomarker both extremes posing Future studies should explore mechanistic pathways interventions targeting prevent high-risk populations.

Language: Английский

Do Statins Affect Cognitive Health? A Narrative Review and Critical Analysis of the Evidence DOI Creative Commons
Richard Kazibwe, Rishi Rikhi, Saeid Mirzai

et al.

Current Atherosclerosis Reports, Journal Year: 2024, Volume and Issue: 27(1)

Published: Nov. 9, 2024

Statins are the first-line treatment for hypercholesterolemia and play a key role in prevention of cardiovascular disease (CVD). Current studies report mixed effects statins on cognitive health, including harmful, neutral, protective outcomes. However, these ongoing controversies about potential adverse may compromise their use CVD prevention. Several factors influence how affect cognition, unique cholesterol homeostasis brain, limited permeability blood-brain barrier to lipoproteins, varying lipophilicity different statins. This review examines evidence linking function considers effect dosages durations.

Language: Английский

Citations

0
Association between calculated remnant cholesterol levels and incident risks of Alzheimer’s disease among elderly patients with type 2 diabetes: a real-world study DOI Creative Commons

Hong Jia,

Liuyu Zhang,

Huijuan Liao

et al.

Frontiers in Endocrinology, Journal Year: 2024, Volume and Issue: 15

Published: Nov. 29, 2024

Alzheimer's disease (AD) is a leading cause of dementia, with rising global burden. Remnant cholesterol (RC), component triglyceride-rich lipoproteins, has been implicated in cardiovascular diseases and metabolic disorders, but its role AD remains unclear. This study investigated the association between RC levels risk among elderly patients type 2 diabetes (T2D) real-world clinical setting. We conducted retrospective cohort using electronic medical records from Gongli Hospital Shanghai Pudong New Area, covering period 2013 to 2023. The included 15,364 aged 65-80 years T2D. were calculated equation. primary outcome was diagnosis AD, validated by neurologists ICD-10-CM code G30. Cox proportional hazards models employed estimate hazard ratios (HRs) for across quartiles levels, adjusting potential confounders. Over mean follow-up 3.69 ± 1.33 years, 312 new cases identified. A U-shaped relationship observed risk, lowest associated 0.58-0.64 mmol/L. Both lower (<0.52 mmol/L) higher (≥0.77 linked increased risk. Compared reference group (Q2: 0.52-0.64 mmol/L), adjusted HRs (95% CI) highest 1.891 (1.368-2.613) (1.363-2.622), respectively. Each 1 mmol/L increase 3.47-fold (HR=4.474, 95% CI 2.330-8.592). may serve as predictive biomarker both extremes posing Future studies should explore mechanistic pathways interventions targeting prevent high-risk populations.

Language: Английский

Citations

0