Structural compromise in spiking cortex and connected networks DOI Creative Commons
Ella Sahlas, Tamir Avigdor, Alexander Ngo

et al.

bioRxiv (Cold Spring Harbor Laboratory), Journal Year: 2024, Volume and Issue: unknown

Published: Oct. 22, 2024

ABSTRACT INTRODUCTION Epilepsy is increasingly conceptualized as a network disorder, and advancing methods for its diagnosis treatment requires characterizing both the epileptic generator related networks. We combined multimodal magnetic resonance imaging (MRI) high-density electroencephalography (HD-EEG) to interrogate alterations in cortical microstructure, morphology, intrinsic local function within beyond spiking tissue focal epilepsy. METHODS studied 25 patients with epilepsy (12F, mean ± SD age = 31.28 9.30 years) 55 age- sex-matched healthy controls, subdivided into group of 30 feature normalization (15F, 31.40 8.74 replication 31.04 5.65 years). The 3T MRI acquisition included T1-weighted, diffusion, quantitative T1 relaxometry, resting-state functional imaging. Open-access processing tools derived cortex-wide maps morphology microstructure (cortical thickness, diffusivity, relaxometry) connectivity (timescales, distance, node strength) all participants. Multivariate approaches generated structural alteration scores each location. Using HD-EEG electrical source imaging, most prominent spike type was localized we quantified sources, well proximal connected RESULTS Regions harboring sources showed increased compared rest brain patients. Structural compromise extended regions close coupling but not anatomical neighbors sources. This finding replicated using average control matrices instead patient-specific matrices. CONCLUSION Spiking contain more marked than remaining cortex, combining neurophysiology techniques may ultimately help identify epileptogenic zone non-invasively. There are nevertheless broader networks effects, which relate cascading changes functionally cortices. These results underscore utility high-definition EEG assessing distributed effects.

Language: Английский

The impact of resective epilepsy surgery on the brain network: evidence from post-surgical imaging DOI Creative Commons
Lucas E. Sainburg, Dario J. Englot, Victoria L. Morgan

et al.

Brain, Journal Year: 2025, Volume and Issue: unknown

Published: Jan. 24, 2025

Abstract Resective epilepsy surgery can be an effective treatment for patients with medication-resistant focal epilepsy. Epilepsy resection consists of the surgical removal epileptic focus to stop seizure generation and disrupt network. However, even resections lead widespread brain network changes. Understanding impact on is crucial improve outcomes patients. Here we provide a summary studies imaging postsurgical effects brain. We MRI PET temporal lobe pediatric epilepsy, reflecting current literature. discuss three potential mechanisms surgery-induced changes: damage degeneration, recovery, reorganization. additionally review correlates as well predict individual patient’s A comprehensive characterization precise methods these changes could more personalized surgeries that reduce neuropsychological deficits after surgery.

Language: Английский

Citations

1
Lethal Interactions of neuronal networks in epilepsy mediated by both synaptic and volume transmission indicate approaches to prevention DOI
Carl L. Faingold

Progress in Neurobiology, Journal Year: 2025, Volume and Issue: 249, P. 102770 - 102770

Published: April 19, 2025

Language: Английский

Citations

0
Change in Structural Connectivity Following Stereotactic Thermocoagulation in Mesial Temporal Lobe Epilepsy Patients DOI Creative Commons
Stéphane Jean, Rifeng Jiang, Yihai Dai

et al.

European Journal of Neurology, Journal Year: 2025, Volume and Issue: 32(4)

Published: April 1, 2025

ABSTRACT Aims To examine the association between postoperative lesions in distinct ROIs of brain and impact that their ablation would have on structural functional connectivity relative to outcomes. Methods We retrospectively reviewed 21 patients with refractory unilateral MTLE. The percentage each ablated gray matter region interest (ROIs) was calculated, using a voxel‐by‐voxel comparison. affected fibers calculated by assessing neuronal change reflected decrease anisotropy repeat scans (i.e., pre postoperative). Graph theory analysis used investigate networks seizure‐free non‐seizure‐free groups. Results Fifteen (71.42%) were six (28.57%) at 12 48 months (23.80 ± 8.93) follow‐up. Four (19.04%) reported memory decline following RFTC. group showed larger volume both amygdala ( p = 0.024) rhinal cortex 0.035), an alteration metrics < 0.05) compared group. Conclusions Our study shows higher led improved associated better results provide insight into some essential elements MTLE might contribute generation novel evidence could improve SEEG‐guided RFTC interventions patients.

Language: Английский

Citations

0
Investigation of network reorganization after epilepsy surgery is worth the effort DOI Creative Commons
Lucas E. Sainburg, Victoria L. Morgan

Brain, Journal Year: 2024, Volume and Issue: 147(7), P. 2261 - 2263

Published: May 30, 2024

This scientific commentary refers to ‘Connectome reorganization associated with temporal lobe pathology and its surgical resection’ by Larivière et al. (https://doi.org/10.1093/brain/awae141).

Language: Английский

Citations

0
Structural compromise in spiking cortex and connected networks DOI Creative Commons
Ella Sahlas, Tamir Avigdor, Alexander Ngo

et al.

bioRxiv (Cold Spring Harbor Laboratory), Journal Year: 2024, Volume and Issue: unknown

Published: Oct. 22, 2024

ABSTRACT INTRODUCTION Epilepsy is increasingly conceptualized as a network disorder, and advancing methods for its diagnosis treatment requires characterizing both the epileptic generator related networks. We combined multimodal magnetic resonance imaging (MRI) high-density electroencephalography (HD-EEG) to interrogate alterations in cortical microstructure, morphology, intrinsic local function within beyond spiking tissue focal epilepsy. METHODS studied 25 patients with epilepsy (12F, mean ± SD age = 31.28 9.30 years) 55 age- sex-matched healthy controls, subdivided into group of 30 feature normalization (15F, 31.40 8.74 replication 31.04 5.65 years). The 3T MRI acquisition included T1-weighted, diffusion, quantitative T1 relaxometry, resting-state functional imaging. Open-access processing tools derived cortex-wide maps morphology microstructure (cortical thickness, diffusivity, relaxometry) connectivity (timescales, distance, node strength) all participants. Multivariate approaches generated structural alteration scores each location. Using HD-EEG electrical source imaging, most prominent spike type was localized we quantified sources, well proximal connected RESULTS Regions harboring sources showed increased compared rest brain patients. Structural compromise extended regions close coupling but not anatomical neighbors sources. This finding replicated using average control matrices instead patient-specific matrices. CONCLUSION Spiking contain more marked than remaining cortex, combining neurophysiology techniques may ultimately help identify epileptogenic zone non-invasively. There are nevertheless broader networks effects, which relate cascading changes functionally cortices. These results underscore utility high-definition EEG assessing distributed effects.

Language: Английский

Citations

0