Understanding the Antidepressant Mechanisms of Acupuncture: Targeting Hippocampal Neuroinflammation, Oxidative Stress, Neuroplasticity, and Apoptosis in CUMS Rats DOI Creative Commons
Jianguo Li, Xinhong Wu,

Simin Yan

et al.

Molecular Neurobiology, Journal Year: 2024, Volume and Issue: 62(4), P. 4221 - 4236

Published: Oct. 18, 2024

Depression is recognized globally as one of the most intractable diseases, and its complexity diversity make treatment extremely challenging. Acupuncture has demonstrated beneficial effects in various psychiatric disorders. However, underlying mechanisms acupuncture's antidepressant action, particularly depression, remain elusive. Therefore, this study aimed to investigate acupuncture on chronic unpredictability stress (CUMS)-induced depressive symptoms rats further elucidate molecular mechanisms. All were exposed CUMS two stressors every day for 28 days, except control group. One hour before CUMS, given a with acupuncture, electroacupuncture, sham-acupuncture, or fluoxetine (2.1 mg/kg). Behavioral tests biological detection methods conducted sequence evaluate depression-like phenotype rats. The findings demonstrate that therapy effectively ameliorated behavior induced by Additionally, exerted restorative effect alterations levels malondialdehyde (MDA), catalase (CAT), superoxide dismutase (SOD), glutathione peroxidase (GSH-Px), interleukin-1β (IL-1β), interleukin-6 (IL-6), tumor necrosis factor-α (TNF-α), brain-derived neurotrophic factor (BDNF), cyclic AMP response element-binding protein (CREB), postsynaptic density95 (PSD95), gamma-aminobutyric acid (GABA), acetylcholine (ACh). our indicate also modulates ERK Caspase-3 apoptotic pathways hippocampus This suggests may play potential preventive role regulating hippocampal neuroinflammatory response, oxidative stress, processes, enhancing synaptic plasticity.

Language: Английский

Vagus nerve stimulation inhibits PANoptosis and promotes neurofunctional recovery of cerebral ischemic stroke in a Sirt1-dependent manner DOI
Hao Tang,

Jun Wen,

Ling Wang

et al.

Neurochemistry International, Journal Year: 2025, Volume and Issue: 184, P. 105950 - 105950

Published: Feb. 18, 2025

Language: Английский

Citations

1
Uncoupling serotonin (2C) and dopamine (D2) receptor heterodimers ameliorate PTSD-like behaviors DOI
Weifen Li,

Tianxiang Li,

Tahir Ali

et al.

Journal of Affective Disorders, Journal Year: 2025, Volume and Issue: unknown

Published: March 1, 2025

Language: Английский

Citations

1
Understanding the Antidepressant Mechanisms of Acupuncture: Targeting Hippocampal Neuroinflammation, Oxidative Stress, Neuroplasticity, and Apoptosis in CUMS Rats DOI Creative Commons
Jianguo Li, Xinhong Wu,

Simin Yan

et al.

Molecular Neurobiology, Journal Year: 2024, Volume and Issue: 62(4), P. 4221 - 4236

Published: Oct. 18, 2024

Depression is recognized globally as one of the most intractable diseases, and its complexity diversity make treatment extremely challenging. Acupuncture has demonstrated beneficial effects in various psychiatric disorders. However, underlying mechanisms acupuncture's antidepressant action, particularly depression, remain elusive. Therefore, this study aimed to investigate acupuncture on chronic unpredictability stress (CUMS)-induced depressive symptoms rats further elucidate molecular mechanisms. All were exposed CUMS two stressors every day for 28 days, except control group. One hour before CUMS, given a with acupuncture, electroacupuncture, sham-acupuncture, or fluoxetine (2.1 mg/kg). Behavioral tests biological detection methods conducted sequence evaluate depression-like phenotype rats. The findings demonstrate that therapy effectively ameliorated behavior induced by Additionally, exerted restorative effect alterations levels malondialdehyde (MDA), catalase (CAT), superoxide dismutase (SOD), glutathione peroxidase (GSH-Px), interleukin-1β (IL-1β), interleukin-6 (IL-6), tumor necrosis factor-α (TNF-α), brain-derived neurotrophic factor (BDNF), cyclic AMP response element-binding protein (CREB), postsynaptic density95 (PSD95), gamma-aminobutyric acid (GABA), acetylcholine (ACh). our indicate also modulates ERK Caspase-3 apoptotic pathways hippocampus This suggests may play potential preventive role regulating hippocampal neuroinflammatory response, oxidative stress, processes, enhancing synaptic plasticity.

Language: Английский

Citations

2