The effects of dopaminergic medication and task load on trembling and akinetic freezing of gait in Parkinson’s disease DOI
Demi Zoetewei, Pieter Ginis,

Talia Herman

et al.

Journal of Neurology, Journal Year: 2025, Volume and Issue: 272(4)

Published: March 28, 2025

Language: Английский

Re-examining the pathobiological basis of gait dysfunction in Parkinson’s disease DOI
Newton Cho, Lorraine V. Kalia, Suneil K. Kalia

et al.

Trends in Neurosciences, Journal Year: 2025, Volume and Issue: unknown

Published: Jan. 1, 2025

Language: Английский

Citations

1
Could adaptive deep brain stimulation treat freezing of gait in Parkinson’s disease? DOI Creative Commons
Philipp Klocke, M. Loeffler, Simon J.G. Lewis

et al.

Journal of Neurology, Journal Year: 2025, Volume and Issue: 272(4)

Published: March 12, 2025

Abstract Next-generation neurostimulators capable of running closed-loop adaptive deep brain stimulation (aDBS) are about to enter the clinical landscape for treatment Parkinson’s disease. Already promising results using aDBS have been achieved symptoms such as bradykinesia, rigidity and motor fluctuations. However, heterogeneity freezing gait (FoG) with its wide range presentations exacerbation cognitive emotional load make it more difficult predict treat. Currently, a successful strategy ameliorate FoG lacks robust oscillatory biomarker. Furthermore, technical implementation suppressing an upcoming episode in real-time represents significant challenge. This review describes neurophysiological signals underpinning explains how is currently being implemented. we offer discussion addressing both theoretical practical areas that will need be resolved if going able unlock full potential treat FoG.

Language: Английский

Citations

1
Neurobiological mechanism of music improving gait disorder in patients with Parkinson’s disease: a mini review DOI Creative Commons
Lingzhi Huang, Qi‐Jun Zhi

Frontiers in Neurology, Journal Year: 2025, Volume and Issue: 15

Published: Jan. 3, 2025

Walking ability is essential for human survival and health. Its basic rhythm mainly generated by the central pattern generator of spinal cord. The rhythmic stimulation music to auditory center affects cerebral cortex other higher nerve centers, acts on generator. By means entrainment, can produce walking synchronized with rhythm, control muscle tension, then regulate gait. Basal ganglia dysfunction main cause abnormal gait in patients Parkinson's disease. Music therapy provides external stimulation, recruits neural networks bypass basal synchronizes rhythms both time space through auditory-motor networks, helping promote improvement patterns

Language: Английский

Citations

0
The effects of dopaminergic medication and task load on trembling and akinetic freezing of gait in Parkinson’s disease DOI
Demi Zoetewei, Pieter Ginis,

Talia Herman

et al.

Journal of Neurology, Journal Year: 2025, Volume and Issue: 272(4)

Published: March 28, 2025

Language: Английский

Citations

0