Neuroinflammation and Central Sensitization in Chronic and Widespread Pain

Anesthesiology, Journal Year: 2018, Volume and Issue: 129(2), P. 343 - 366

Published: Feb. 16, 2018

Abstract Chronic pain is maintained in part by central sensitization, a phenomenon of synaptic plasticity, and increased neuronal responsiveness pathways after painful insults. Accumulating evidence suggests that sensitization also driven neuroinflammation the peripheral nervous system. A characteristic feature activation glial cells, such as microglia astrocytes, spinal cord brain, leading to release proinflammatory cytokines chemokines. Recent studies suggest chemokines are powerful neuromodulators play sufficient role inducing hyperalgesia allodynia system administration. Sustained increase promotes chronic widespread affects multiple body sites. Thus, drives via sensitization. We discuss sex-dependent glial/immune signaling new therapeutic approaches control for resolution pain.

Language: Английский

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The Role of Psychosocial Processes in the Development and Maintenance of Chronic Pain

Journal of Pain, Journal Year: 2016, Volume and Issue: 17(9), P. T70 - T92

Published: Aug. 30, 2016

Language: Английский

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Microglia in neuropathic pain: cellular and molecular mechanisms and therapeutic potential

Nature reviews. Neuroscience, Journal Year: 2018, Volume and Issue: 19(3), P. 138 - 152

Published: Feb. 8, 2018

Language: Английский

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Microglia in Pain: Detrimental and Protective Roles in Pathogenesis and Resolution of Pain

Neuron, Journal Year: 2018, Volume and Issue: 100(6), P. 1292 - 1311

Published: Dec. 1, 2018

Language: Английский

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Structural plasticity and reorganisation in chronic pain

Nature reviews. Neuroscience, Journal Year: 2016, Volume and Issue: 18(1), P. 20 - 30

Published: Dec. 15, 2016

Language: Английский

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TFOS DEWS II pain and sensation report

The Ocular Surface, Journal Year: 2017, Volume and Issue: 15(3), P. 404 - 437

Published: July 1, 2017

Language: Английский

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Evaluating psychosocial contributions to chronic pain outcomes

Progress in Neuro-Psychopharmacology and Biological Psychiatry, Journal Year: 2018, Volume and Issue: 87, P. 168 - 182

Published: Jan. 31, 2018

Language: Английский

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Roles of inflammation, neurogenic inflammation, and neuroinflammation in pain

Journal of Anesthesia, Journal Year: 2018, Volume and Issue: 33(1), P. 131 - 139

Published: Nov. 17, 2018

Language: Английский

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Astrocytes in chronic pain and itch

Nature reviews. Neuroscience, Journal Year: 2019, Volume and Issue: 20(11), P. 667 - 685

Published: Sept. 19, 2019

Language: Английский

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The Dorsolateral Prefrontal Cortex in Acute and Chronic Pain

Journal of Pain, Journal Year: 2017, Volume and Issue: 18(9), P. 1027 - 1035

Published: April 8, 2017

Language: Английский

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