Reduced resilience of brain state transitions in anti-N-Methyl-D-Aspartate receptor encephalitis DOI Open Access
Nina von Schwanenflug, Juan Pablo Ramírez-Mahaluf, Stephan Krohn

et al.

bioRxiv (Cold Spring Harbor Laboratory), Journal Year: 2022, Volume and Issue: unknown

Published: Jan. 24, 2022

ABSTRACT Objective Patients with anti-NMDA receptor encephalitis suffer from a severe neuropsychiatric syndrome, yet most patients show no abnormalities in routine magnetic resonance imaging. In contrast, advanced neuroimaging studies have consistently identified disrupted functional connectivity these patients, recent work suggesting increased volatility of state dynamics. Here, we investigate network dynamics through the spatiotemporal trajectory meta-state transitions, yielding time-resolved account brain exploration encephalitis. Methods Resting-state imaging data were acquired 73 NMDAR and age- sex-matched healthy controls. Time-resolved was clustered into meta-states, giving rise to transition graph states as nodes transitions between meta-states weighted, directed edges. Network topology, robustness, cost networks compared groups. Results Transition showed significantly lower local efficiency ( t = -2.54, p FDR 0.026), robustness -2.01, 0.048) higher leap size 2.33, 0.026) Furthermore, ratio within-to-between module similarity patients. Importantly, alterations correlated disease severity. Interpretation These findings reveal systematic that is characterized by reduced stability this resilience plays clinically relevant role manifestation disease.

Language: Английский

Altered Dynamic Resting State Functional Connectivity Associated With Somatosensory Impairments in the Upper Limb in the Early Sub-Acute Phase Post-Stroke DOI
Nele De Bruyn, Anna K. Bonkhoff, Leen Saenen

et al.

Neurorehabilitation and neural repair, Journal Year: 2023, Volume and Issue: 37(7), P. 423 - 433

Published: June 23, 2023

Altered dynamic functional connectivity has been associated with motor impairments in the acute phase post-stroke. Its association somatosensory early sub-acute remains unexplored.To investigate altered post-stroke.We collected resting state magnetic resonance imaging and clinical function of upper limb 20 subacute stroke patients 16 healthy controls (HC). A sliding-window approach was used to identify 3 states based on estimated sensorimotor related networks. Network components were subdivided into domains: cortical subcortical sensorimotor, as well cognitive control network. Between-group differences investigated using independent t-tests Mann-Whitney-U tests. Analyzes performed correction for age, head motion time post-stroke corrected multiple comparisons.Stroke spent significantly less a weakly connected network (state 3; dwell time: pstate3 = 0.003, meanstroke 53.02, SDstroke 53.13; meanHC 118.92, SDHC 72.84), stayed shorter but more intervals highly intra-domain 1; fraction pstate 1 < 0.001, 0.46, 0.26; 0.26, 0.21) compared HC. After 8 weeks therapy, improvements wrist proprioception moderately decreases times toward normalized pattern.Changes temporal properties large-scale interactions are present rehabilitation could indicate enhanced neural plasticity. These findings augment understanding cerebral reorganization after loss tissue specialized functions.

Language: Английский

Citations

2
Dynamic and static changes of amplitude of low-frequency fluctuations in anti‑N‑methyl‑D‑aspartate receptor encephalitis DOI

Dongpeng Wu,

Yuanyuan Guo, Chenglong Li

et al.

Brain Imaging and Behavior, Journal Year: 2023, Volume and Issue: 17(6), P. 652 - 663

Published: Sept. 6, 2023

Language: Английский

Citations

2
Psychiatrische Autoimmunenzephalitis – Diagnose und therapeutische Ansätze DOI Open Access
Niels Hansen, Daniel Lüdecke, Hannah Benedictine Maier

et al.

PSYCH up2date, Journal Year: 2023, Volume and Issue: 17(01), P. 13 - 28

Published: Jan. 1, 2023

Eine Autoimmunenzephalitis ist eine entzündliche Erkrankung des zentralen Nervensystems, die neben neurologischen Symptomen häufig und teils sogar vorwiegend durch psychiatrische Symptome gekennzeichnet sein kann. Bei überwiegend psychiatrischer Manifestation wird sie als „psychiatrische Autoimmunenzephalitis“ bezeichnet. Die Übersicht zeigt den aktuellen Stand zur Pathogenese Diagnostik sowie verschiedene Therapiemöglichkeiten der Immuntherapie auch Psychopharmakologie.

Citations

1
Abnormal large-scale resting-state functional networks in anti-N-methyl-D-aspartate receptor encephalitis DOI Creative Commons

Xiarong Gong,

Libo Wang, Yuanyuan Guo

et al.

Frontiers in Neuroscience, Journal Year: 2024, Volume and Issue: 18

Published: Aug. 19, 2024

Patients with anti-N-methyl-D-aspartate receptor (anti-NMDAR) encephalitis often experience severe symptoms. Resting-state functional MRI (rs-fMRI) has revealed widespread impairment of networks in patients. However, the changes information flow remain unclear. This study aims to investigate intrinsic connectivity (FC) both within and between resting-state (RSNs), as well alterations effective (EC) these networks. data were collected from 25 patients anti-NMDAR 30 healthy controls (HCs) matched for age, sex, educational level. Changes RSNs analyzed using independent component analysis (ICA). The interaction was identified by granger causality (GCA). Compared HCs, exhibited lower performance on Wisconsin Card Sorting Test (WCST), terms correct numbers categories. Additionally, demonstrated decreased scores Montreal Cognitive Assessment (MoCA). Neuroimaging studies abnormal intra-FC default mode network (DMN), increased visual (VN) dorsal attention (DAN), inter-FC VN frontoparietal (FPN). Furthermore, aberrant observed among DMN, DAN, FPN, VN, somatomotor (SMN). displayed noticeable deficits memory executive function. Notably, impairments intra-FC, inter-FC, EC. These results may help explain pathophysiological mechanism encephalitis.

Language: Английский

Citations

0
Functional connectivity dynamics reflect disability and multi-domain clinical impairment in patients with relapsing-remitting multiple sclerosis DOI Open Access
Amy Romanello, Stephan Krohn, Nina von Schwanenflug

et al.

bioRxiv (Cold Spring Harbor Laboratory), Journal Year: 2022, Volume and Issue: unknown

Published: May 12, 2022

ABSTRACT Background Functional neuroimaging studies have revealed complex and heterogeneous patterns of aberrant functional connectivity (FC) in multiple sclerosis (MS), yet it remains unclear how time-resolved FC relates to variance clinical disease severity. Objectives To characterize brain activity MS patients with analysis explore the relationship between severity, multi-domain impairments, altered network dynamics. Methods Resting-state MRI data were acquired from 101 age- sex-matched healthy controls (HC). Dynamic identified five states that compared HC high vs. low disability. Results Patients higher severity exhibited a more widespread spatiotemporal pattern spent time high-connectivity, low-occurrence state lower HC. Depressive symptom was positively related dynamics on global scales patients, while fatigue motor impairment inversely frontoparietal basal ganglia. Conclusions Time-resolved uncovered alterations correlations remained undetected static account activity. Such time-varying approaches are thus crucial for disentangling dynamics, symptoms MS.

Language: Английский

Citations

2
Reduced resilience of brain state transitions in anti-N-Methyl-D-Aspartate receptor encephalitis DOI Open Access
Nina von Schwanenflug, Juan Pablo Ramírez-Mahaluf, Stephan Krohn

et al.

bioRxiv (Cold Spring Harbor Laboratory), Journal Year: 2022, Volume and Issue: unknown

Published: Jan. 24, 2022

ABSTRACT Objective Patients with anti-NMDA receptor encephalitis suffer from a severe neuropsychiatric syndrome, yet most patients show no abnormalities in routine magnetic resonance imaging. In contrast, advanced neuroimaging studies have consistently identified disrupted functional connectivity these patients, recent work suggesting increased volatility of state dynamics. Here, we investigate network dynamics through the spatiotemporal trajectory meta-state transitions, yielding time-resolved account brain exploration encephalitis. Methods Resting-state imaging data were acquired 73 NMDAR and age- sex-matched healthy controls. Time-resolved was clustered into meta-states, giving rise to transition graph states as nodes transitions between meta-states weighted, directed edges. Network topology, robustness, cost networks compared groups. Results Transition showed significantly lower local efficiency ( t = -2.54, p FDR 0.026), robustness -2.01, 0.048) higher leap size 2.33, 0.026) Furthermore, ratio within-to-between module similarity patients. Importantly, alterations correlated disease severity. Interpretation These findings reveal systematic that is characterized by reduced stability this resilience plays clinically relevant role manifestation disease.

Language: Английский

Citations

0