A cortico-subcortical loop for motor control via the pontine reticular formation DOI Open Access
Emília Bősz, Viktor Plattner, László Bíró

et al.

bioRxiv (Cold Spring Harbor Laboratory), Journal Year: 2023, Volume and Issue: unknown

Published: Aug. 12, 2023

Summary Movement and locomotion are controlled by large neuronal circuits like the cortex-basal ganglia (BG)-thalamus loop. Inhibitory output of BG loop can directly control movement via specialized connections with brainstem. Whether other parallel loops similar logic exist is presently unclear. Here we demonstrate that glycine transporter 2-positive (GlyT2+) cells pontine reticular formation (PRF) receive cortical inputs in turn innervate thalamus. Thalamus-projecting GlyT2+ subcortical regions distinct from targets. Cortical co-innervate PRF/GlyT2+ thalamus as loops. Cortex exerts strong excitatory on these neurons powerfully inhibit their thalamic Activation projecting leads to contralateral turning. These results PRF part a cortico-subcortical regulates motor activity circuits. The cortico-PRF-thalamus synergistically turning descending pathways. Graphical abstract

Language: Английский

The brain’s action-mode network DOI
Nico U.F. Dosenbach,

Marcus E. Raichle,

Evan M. Gordon

et al.

Nature reviews. Neuroscience, Journal Year: 2025, Volume and Issue: unknown

Published: Jan. 2, 2025

Language: Английский

Citations

13
A Comprehensive Review of Emerging Trends and Innovative Therapies in Epilepsy Management DOI Creative Commons
Shampa Ghosh, Jitendra Kumar Sinha, Soumya K. Ghosh

et al.

Brain Sciences, Journal Year: 2023, Volume and Issue: 13(9), P. 1305 - 1305

Published: Sept. 11, 2023

Epilepsy is a complex neurological disorder affecting millions worldwide, with substantial number of patients facing drug-resistant epilepsy. This comprehensive review explores innovative therapies for epilepsy management, focusing on their principles, clinical evidence, and potential applications. Traditional antiseizure medications (ASMs) form the cornerstone treatment, but limitations necessitate alternative approaches. The delves into cutting-edge such as responsive neurostimulation (RNS), vagus nerve stimulation (VNS), deep brain (DBS), highlighting mechanisms action promising outcomes. Additionally, gene optogenetics in research discussed, revealing groundbreaking findings that shed light seizure mechanisms. Insights cannabidiol (CBD) ketogenic diet adjunctive further broaden spectrum management. Challenges achieving control traditional therapies, including treatment resistance individual variability, are addressed. importance staying updated emerging trends management emphasized, along hope improved therapeutic options. Future directions, combining AI applications, non-invasive optogenetics, hold promise personalized effective treatment. As field advances, collaboration among researchers natural synthetic biochemistry, clinicians from different streams various forms medicine, will drive progress toward better higher quality life individuals living

Language: Английский

Citations

36
A cortico-subcortical loop for motor control via the pontine reticular formation DOI
Emília Bősz, Viktor Plattner, László Bíró

et al.

Cell Reports, Journal Year: 2025, Volume and Issue: 44(2), P. 115230 - 115230

Published: Jan. 22, 2025

Language: Английский

Citations

1
Human high-order thalamic nuclei gate conscious perception through the thalamofrontal loop DOI
Zepeng Fang, Yuanyuan Dang,

Anan Ping

et al.

Science, Journal Year: 2025, Volume and Issue: 388(6742)

Published: April 4, 2025

Human high-order thalamic nuclei activity is known to closely correlate with conscious states. However, it not clear how those and thalamocortical interactions directly contribute the transient process of human perception. We simultaneously recorded stereoelectroencephalography data from prefrontal cortex (PFC), while patients implanted electrodes performed a visual consciousness task. Compared ventral PFC, intralaminar medial presented earlier stronger consciousness-related activity. Transient thalamofrontal neural synchrony cross-frequency coupling were both driven by θ phase during The thus play gate role drive PFC emergence

Language: Английский

Citations

1
Deep brain stimulation of the central thalamus restores arousal and motivation in a zolpidem-responsive patient with akinetic mutism after severe brain injury DOI Creative Commons
Hisse Arnts, Prejaas Tewarie, Willemijn S. van Erp

et al.

Scientific Reports, Journal Year: 2024, Volume and Issue: 14(1)

Published: Feb. 5, 2024

Abstract After severe brain injury, zolpidem is known to cause spectacular, often short-lived, restorations of functions in a small subgroup patients. Previously, we showed that these zolpidem-induced neurological recoveries can be paralleled by significant changes functional connectivity throughout the brain. Deep stimulation (DBS) neurosurgical intervention modulate wide variety disorders. In this study, used DBS restore arousal and motivation zolpidem-responsive patient with injury concomitant disorder diminished motivation, more than 10 years after surviving hypoxic ischemia. We found central thalamus, targeted at centromedian-parafascicular complex, immediately restored was able transition from state deep sleep full wakefulness. Moreover, associated temporary restoration communication ability walk eat an otherwise wheelchair-bound mute patient. With use magnetoencephalography (MEG), revealed generally marked decrease aberrantly high levels brain, mimicking effects zolpidem. These results imply ‘pathological hyperconnectivity’ reduced behavioral performance towards ‘healthier baseline’ lower synchronization, and, networks long injury. The presence hyperconnectivity may possible future marker for patient’s responsiveness restorative interventions, such as DBS, suggests degrees overall synchronization conducive cognition responsiveness.

Language: Английский

Citations

5
Deep brain stimulation in disorders of consciousness: 10 years of a single center experience DOI Creative Commons
Darko Chudy,

Vedran Deletis,

Veronika Paradžik

et al.

Scientific Reports, Journal Year: 2023, Volume and Issue: 13(1)

Published: Nov. 9, 2023

Disorders of consciousness (DoC), namely unresponsive wakefulness syndrome (UWS) and minimally conscious state (MCS), represent severe conditions with significant consequences for patients their families. Several studies have reported the regaining in such using deep brain stimulation (DBS) subcortical structures or brainstem nuclei. Our study aims to present 10 years' experience a single center DBS as therapy on cohort DoC. Eighty Three consecutive were evaluated between 2011 2022; entry criteria consisted neurophysiological neurological evaluations neuroimaging examinations. Out 83, 36 considered candidates implantation, 32 implanted: 27 had UWS, five MCS. The target was centromedian-parafascicular complex left hemisphere hypoxic lesion one better preserved traumatic injury. level improved seven patients. out MCS emerged full awareness, ability interact communicate. Two them can live largely independently. Four UWS showed improvement two emerging other reaching In DoC lasting longer than 12 months following injury 6 anoxic-ischemic lesion, spontaneous recovery is rare. Thus, certain thalamic nuclei could be recommended treatment option who meet neurological, criteria, especially earlier phases, before occurrence irreversible musculoskeletal changes. Furthermore, we emphasize importance cooperation centers worldwide potentials treating

Language: Английский

Citations

13
Radiosurgery to the Medial Thalamus for Chronic Pain: A Single Group Experience and Review of Literature DOI Open Access

Paola Del Cid,

Alejandra Moreira,

Fidel Campos

et al.

Cureus, Journal Year: 2025, Volume and Issue: unknown

Published: April 25, 2025

Language: Английский

Citations

0
Antifragile control systems in neuronal processing: a sensorimotor perspective DOI Creative Commons
Cristian Axenie

Biological Cybernetics, Journal Year: 2025, Volume and Issue: 119(2-3)

Published: Feb. 15, 2025

Language: Английский

Citations

0
Neuroscience of coma DOI
Abid Qureshi, Robert D. Stevens

Handbook of clinical neurology, Journal Year: 2025, Volume and Issue: unknown, P. 29 - 47

Published: Jan. 1, 2025

Language: Английский

Citations

0
Cholecystokinin neurons in the spinal trigeminal nucleus interpolaris regulate mechanically evoked predatory hunting in male mice DOI Creative Commons
Dandan Geng, Yaning Li, Bo Yang

et al.

Nature Communications, Journal Year: 2025, Volume and Issue: 16(1)

Published: March 14, 2025

Predatory hunting plays a critical role in animal survival. Motion-related vibrissal somatosensory signaling is essential for prey detection and mice. However, little known about the neural circuits that convert cues to trigger predatory hunting. Here, we report mechanical force onto area of male mice key stimulus Mechanically evoked was abrogated by chemogenetic inactivation cholecystokinin-positive (Cck+) neurons spinal trigeminal nucleus interpolaris (Sp5I). The Cck+ Sp5I responded intensity sent signals superior colliculus were relevant stereotypical motor actions. Synaptic projections from impaired mechanically attacks. Together, these data reveal circuit specifically engaged translating provoke This study reveals respond vibrissae stimuli send inputs colliculus, which are behaviour.

Language: Английский

Citations

0